2′-Deoxyadenosine 5′-monophosphate-¹³C₁₀,¹⁵N₅ disodium

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2′-Deoxyadenosine 5′-monophosphate-¹³C₁₀,¹⁵N₅ (disodium) is the ¹³C and ¹⁵N labeled 2′-Deoxyadenosine 5′-monophosphate disodium. 2′-Deoxyadenosine 5′-monophosphate disodium, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate disodium can be used to study adenosine-based interactions during DNA synthesis and DNA damage.

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2′-Deoxyadenosine 5′-monophosphate-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>5</sub> disodium

2′-Deoxyadenosine 5′-monophosphate-¹³C₁₀,¹⁵N₅ disodium Chemical Structure

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Other Forms of 2′-Deoxyadenosine 5′-monophosphate-¹³C₁₀,¹⁵N₅ disodium:

2′-Deoxyadenosine 5′-monophosphate disodium In-stock

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Description

2′-Deoxyadenosine 5′-monophosphate-¹³C₁₀,¹⁵N₅ (disodium) is the ¹³C and ¹⁵N labeled 2′-Deoxyadenosine 5′-monophosphate disodium^[1]. 2′-Deoxyadenosine 5′-monophosphate disodium, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate disodium can be used to study adenosine-based interactions during DNA synthesis and DNA damage^[2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

390.08

Formule

¹³C₁₀H₁₂¹⁵N₅Na₂O₆P

Unlabeled CAS

2922-74-9

Appearance

Solid

Color

White to off-white

SMILES

[15NH2][13C]1=[15N][13CH]=[15N][13C]2=[13C]1[15N]=[13CH][15N]2[13C@H]3[13CH2][13C@H](O)[13C@@H]([13CH2]OP(O[Na])(O[Na])=O)O3

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

Purity: 99.8%

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Fiche technique (278 KB) SDS (252 KB)

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Références

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Katsuya Narumi, et al. Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP. PLoS One. 2019 Oct 21;14(10):e0223892. [Content Brief]

[3]. V Duarte, et al. Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanine. Nucleic Acids Res. 1999 Jan 1527(2):496-502. [Content Brief]