2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. (2R,4R)-APDC

(2R,4R)-APDC  (Synonyms: (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid)

Cat. No.: HY-102091
Handling Instructions Technical Support

(2R,4R)-APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC can be used in the study of epilepsy and other neurological diseases.

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(2R,4R)-APDC

(2R,4R)-APDC 화학구조

CAS No. : 169209-63-6

사이즈 가격 재고 수량
5 mg 견적 받기 3 - 4 Weeks 4 - 5 weeks 5 - 6 weeks 2 - 3 weeks
10 mg 견적 받기 3 - 4 Weeks 4 - 5 weeks 5 - 6 weeks 2 - 3 weeks
50 mg   견적 받기  
100 mg   견적 받기  
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고객리뷰

Based on 1 Customer Validation

Other Forms of (2R,4R)-APDC:

(2R,4R)-APDC Related Antibodies

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

(2R,4R)-APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC can be used in the study of epilepsy and other neurological diseases[1][2].

IC50 & Target[1]

group II mGlu receptors

 

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
> 100 3
Compound: 18
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
[PMID: 15801843]
HEK293 EC50
> 100 3
Compound: 18
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
[PMID: 15801843]
HEK293 EC50
>100 3
Compound: 18
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
[PMID: 15801843]
In Vivo

2R, 4R-APDC (1-10 nmol; ICV; daily for 14 days) decreases cell proliferation in the dentate gyrus[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats weighing between 300 and 350 g[2]
Dosage: 1 nmol/10 μl; 10 nmol/10μl
Administration: ICV; daily for 14 days
Result: Resulted in decreased BrdU-immunoreactive cells in the DG.
분자량

174.15

화학식

C6H10N2O4
CAS No.
SMILES

O=C([C@@H]1NC[C@](C(O)=O)(N)C1)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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(2R,4R)-APDC Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(2R,4R)-APDC169209-63-6(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acidmGluRMetabotropic glutamate receptorsanticonvulsantneuroprotectivecellproliferationdentategyrusInhibitorinhibitorinhibit

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상품명:
(2R,4R)-APDC
Cat. No.:
HY-102091
수량:
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