2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Afloqualone

Afloqualone (HQ-495) is an orally active central muscle relaxant and antivertiginous agent that can increase the sensitivity of GABA receptors in neurons of the lateral vestibular nucleus. Afloqualone (HQ-495) can be used in the research of low back pain and neck-arm-shoulder syndrome.

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Afloqualone

Afloqualone Estructura química

No. CAS : 56287-74-2

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Descripciòn

Afloqualone (HQ-495) is an orally active central muscle relaxant and antivertiginous agent that can increase the sensitivity of GABA receptors in neurons of the lateral vestibular nucleus. Afloqualone (HQ-495) can be used in the research of low back pain and neck-arm-shoulder syndrome[1][2][3].

In Vivo

Afloqualone (intravenous injection; 5-20 mg/kg; single dose) inhibits the mono-synaptic and poly-synaptic reflex potentials in a dose-dependent manner in spinalized cats[1].
Afloqualone (oral administration; 10-35 mg/kg; single dose) can relax γ-rigidity and α-rigidity in rats in a dose-dependent manner[1].
Afloqualone (oral administration; 5-10 mg/kg; single dose) inhibits vestibular nystagmus in a dose-dependent manner in spinalized cats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular

283.30

Fòrmula

C16H14FN3O
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC=CC=C2C)C(CF)=NC3=C1C=C(N)C=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvente y solubilidad
In Vitro: 

DMSO : 116.67 mg/mL (411.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5298 mL 17.6491 mL 35.2983 mL
5 mM 0.7060 mL 3.5298 mL 7.0597 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Pureza y Documentación

Purity: 99.94%

SDS (393 KB)

COA (249 KB) RP-HPLC (242 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5298 mL 17.6491 mL 35.2983 mL 88.2457 mL
5 mM 0.7060 mL 3.5298 mL 7.0597 mL 17.6491 mL
10 mM 0.3530 mL 1.7649 mL 3.5298 mL 8.8246 mL
15 mM 0.2353 mL 1.1766 mL 2.3532 mL 5.8830 mL
20 mM 0.1765 mL 0.8825 mL 1.7649 mL 4.4123 mL
25 mM 0.1412 mL 0.7060 mL 1.4119 mL 3.5298 mL
30 mM 0.1177 mL 0.5883 mL 1.1766 mL 2.9415 mL
40 mM 0.0882 mL 0.4412 mL 0.8825 mL 2.2061 mL
50 mM 0.0706 mL 0.3530 mL 0.7060 mL 1.7649 mL
60 mM 0.0588 mL 0.2942 mL 0.5883 mL 1.4708 mL
80 mM 0.0441 mL 0.2206 mL 0.4412 mL 1.1031 mL
100 mM 0.0353 mL 0.1765 mL 0.3530 mL 0.8825 mL
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Afloqualone Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Afloqualone56287-74-2HQ-495HQ495HQ 495GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorLVN neuronspinalized catsInhibitorinhibitorinhibit

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Nombre del producto:
Afloqualone
Cat. No.:
HY-B1833
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