56287-74-2
56287-74-2
Chemical Structure
Afloqualone
Synonym(s): HQ-495
- CAS No.: 56287-74-2
- Formula:C16H14FN3O
- Molecular Weight:283.30
IUPAC Name: 6-amino-2-(fluoromethyl)-3-(o-tolyl)quinazolin-4(3H)-one
InChIKey: VDOSWXIDETXFET-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC=CC=C2C)C(CF)=NC3=C1C=C(N)C=C3
Biological Activity: Afloqualone (HQ-495) is an orally active central muscle relaxant and antivertiginous agent that can increase the sensitivity of GABA receptors in neurons of the lateral vestibular nucleus. Afloqualone (HQ-495) can be used in the research of low back pain and neck-arm-shoulder syndrome[1][2][3].
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Afloqualone | 99.94% | Afloqualone (HQ-495) is an orally active central muscle relaxant and antivertiginous agent that can increase the sensitivity of GABA receptors in neurons of the lateral vestibular nucleus. Afloqualone (HQ-495) can be used in the research of low back pain and neck-arm-shoulder syndrome. | ||||||||||||||||||||
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Afloqualone (Standard) | ≥98% | Afloqualone (Standard) is the analytical standard of Afloqualone. This product is intended for research and analytical applications. Afloqualone (HQ-495) is an orally active central muscle relaxant and antivertiginous agent that can increase the sensitivity of GABA receptors in neurons of the lateral vestibular nucleus. Afloqualone (HQ-495) can be used in the research of low back pain and neck-arm-shoulder syndrome. | ||||||||||||||||||||
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Afloqualone-d7 | Afloqualone-d7 (HQ-495-d7) is deuterium labeled Afloqualone. Afloqualone (HQ-495) is an orally active central muscle relaxant and antivertiginous agent that can increase the sensitivity of GABA receptors in neurons of the lateral vestibular nucleus. Afloqualone (HQ-495) can be used in the research of low back pain and neck-arm-shoulder syndrome. | |||||||||||||||||||||
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References
- [1]. T Ochiai, et al. Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. Jpn J Pharmacol. 1982 Jun;32(3):427-38. [Content Brief]
- [2]. Y Kudo, et al. Effects of afloqualone on vestibular nystagmus and the lateral vestibular nucleus. Jpn J Pharmacol. 1989 Aug;50(4):515-9. [Content Brief]
- [3]. A INOUE, et al. Clinical Effect of Afloqualone (HQ-495) on Low Back Pain and Neck-Arm-Shoulder Syndrome By a Double Blind Trial in Comparison with Tolperisone. Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 1981, 12(1): 137-154.
