2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Amezinium methylsulfate

Amezinium methylsulfate  (Synonyms: Amezinium metilsulfate; Lu-1631)

Art. -Nr.: HY-A0275 Reinheit: 99.77%
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Handling Instructions Technical Support

Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake.

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Amezinium methylsulfate

Amezinium methylsulfate Chemische Struktur

CAS. Nr. : 30578-37-1

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10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO Auf Lager
Solid
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1 g Auf Lager
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Amezinium methylsulfate Related Antibodies

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Beschreibung

Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake. Target: alpha and beta-1 receptors Amezinium metilsulfate is a sympathomimetic drug used for the treatment of low blood pressure. Cardiovascular effects of the new sympathomimetic Amezinium metilsulphate are investigated in 25 patients compared with a control group (n = 25). During spinal/epidural anaesthesia 5 mg amezinium is given i.v. if blood pressure dropped greater than 20 mmHg. from starting-point. A significant recovery of blood pressure (epidural anaesthesia: syst 21%, diast 9%; spinal anaesthesia: syst 13%, diast 6.6%) and a decrease in heart rate (6.8% resp. 4,5%) are thought due to peripheral vasoconstriction. Amezinium proves a stimulating drug for alpha- and beta 1-receptors by stabilising the systemic blood pressure in spinal/epidural anaesthesia.

Molekulargewicht

313.33

Formel

C12H15N3O5S
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC(N)=CN=[N+]1C2=CC=CC=C2.O=S(OC)([O-])=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit
In Vitro: 

H2O : 50 mg/mL (159.58 mM; Need ultrasonic)

DMSO : ≥ 34 mg/mL (108.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1915 mL 15.9576 mL 31.9152 mL
5 mM 0.6383 mL 3.1915 mL 6.3830 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 11.11 mg/mL (35.46 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.1915 mL 15.9576 mL 31.9152 mL 79.7881 mL
5 mM 0.6383 mL 3.1915 mL 6.3830 mL 15.9576 mL
10 mM 0.3192 mL 1.5958 mL 3.1915 mL 7.9788 mL
15 mM 0.2128 mL 1.0638 mL 2.1277 mL 5.3192 mL
20 mM 0.1596 mL 0.7979 mL 1.5958 mL 3.9894 mL
25 mM 0.1277 mL 0.6383 mL 1.2766 mL 3.1915 mL
30 mM 0.1064 mL 0.5319 mL 1.0638 mL 2.6596 mL
40 mM 0.0798 mL 0.3989 mL 0.7979 mL 1.9947 mL
50 mM 0.0638 mL 0.3192 mL 0.6383 mL 1.5958 mL
60 mM 0.0532 mL 0.2660 mL 0.5319 mL 1.3298 mL
80 mM 0.0399 mL 0.1995 mL 0.3989 mL 0.9974 mL
100 mM 0.0319 mL 0.1596 mL 0.3192 mL 0.7979 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Amezinium methylsulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amezinium30578-37-1Amezinium metilsulfate Lu-1631Lu1631Lu 1631Lu-1631Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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