Artemisone (Synonyms: Artemifone; BAY 44-9585)

Name: Artemisone
Brand: MedChemExpress
SKU: HY-19502
Rating: 4.5 (1 reviews)

Cat. No.: HY-19502 Pureza: 98.0%: Ficha de datos
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SDS
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Artemisone (Artemifone) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains, with a mean IC₅₀ of 0.83 nM. Artemisone is also a potent inhibitor of human CMV.

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Artemisone Estructura química

No. CAS : 255730-18-8

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of Artemisone:

Artemisone (Standard) Obtener un presupuesto

1 Publications Citing Use of MCE Artemisone

•ACS Infect Dis. 2020 Sep 11;6(9):2524-2531. [Abstract]

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Ver todos los productos específicos de isoformas Parasite:

Ver todas las isoformas

Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Artemisone (Artemifone) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains, with a mean IC₅₀ of 0.83 nM^[1]. Artemisone is also a potent inhibitor of human CMV^[2].

IC₅₀ & Target

Plasmodium

Cellular Effect

Cell Line	Type	Value	Description	References
HFF	EC₅₀	30 μM Compound: Artemisone	Antiparasitic activity against Toxoplasma gondii ATCC 50839 infected in HFF cells after 72 hrs by beta-galactosidase reporter gene assay Antiparasitic activity against Toxoplasma gondii ATCC 50839 infected in HFF cells after 72 hrs by beta-galactosidase reporter gene assay	[PMID: 17698618]
HepG2	IC₅₀	0.04 μM Compound: Artemisone	Antimalarial activity against sporozoite stage of Plasmodium berghei yoelii infected in human HepG2 cells Antimalarial activity against sporozoite stage of Plasmodium berghei yoelii infected in human HepG2 cells	[PMID: 26640981]

In Vitro

Artemisone inhibits 3D7 and K1 P. falciparum, with IC₅₀s of 0.88±0.59 and 1.23±0.64 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Artemisone is effectve at inhibiting the parasitaemia in the P. berghei NY susceptible strain, with an ED₅₀ of 9.62 mg/kg via subcutaneous route and 11.67 mg/kg via oral administration^[1].
Artemisone (3, 1, 0.3 and 0.1 mg/kg, s.c.) in combination with ohter antimalarials has enhanced effect against the chloroquine-resistant line P. yoelii NS^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

401.52

Fòrmula

C₁₉H₃₁NO₆S

No. CAS

255730-18-8

Appearance

Solid

Color

White to off-white

SMILES

C[C@H]1[C@H](N2CCS(CC2)(=O)=O)O[C@@]3([H])[C@]45[C@@]([C@H](C)CC[C@]51[H])([H])CC[C@@](O3)(C)OO4

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvente y solubilidad

In Vitro:

DMSO : 130 mg/mL (323.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4905 mL	12.4527 mL	24.9054 mL
5 mM	0.4981 mL	2.4905 mL	4.9811 mL
10 mM	0.2491 mL	1.2453 mL	2.4905 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.17 mg/mL (5.40 mM); Clear solution

This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.17 mg/mL (5.40 mM); Clear solution

This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.17 mg/mL (5.40 mM); Clear solution

This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureza y Documentación

Purity: 98.0%

Select Batch:

Ficha de datos (277 KB) SDS (252 KB)

COA (255 KB) HNMR (246 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Vivas L, et al. Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo. J Antimicrob Chemother. 2007 Apr;59(4):658-65. [Content Brief]

[2]. Ruiyuan Cao, et al. Anti-SARS-CoV-2 Potential of Artemisinins In Vitro. ACS Infect. Dis. 2020 Jul.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4905 mL	12.4527 mL	24.9054 mL	62.2634 mL
	5 mM	0.4981 mL	2.4905 mL	4.9811 mL	12.4527 mL
	10 mM	0.2491 mL	1.2453 mL	2.4905 mL	6.2263 mL
	15 mM	0.1660 mL	0.8302 mL	1.6604 mL	4.1509 mL
	20 mM	0.1245 mL	0.6226 mL	1.2453 mL	3.1132 mL
	25 mM	0.0996 mL	0.4981 mL	0.9962 mL	2.4905 mL
	30 mM	0.0830 mL	0.4151 mL	0.8302 mL	2.0754 mL
	40 mM	0.0623 mL	0.3113 mL	0.6226 mL	1.5566 mL
	50 mM	0.0498 mL	0.2491 mL	0.4981 mL	1.2453 mL
	60 mM	0.0415 mL	0.2075 mL	0.4151 mL	1.0377 mL
	80 mM	0.0311 mL	0.1557 mL	0.3113 mL	0.7783 mL
	100 mM	0.0249 mL	0.1245 mL	0.2491 mL	0.6226 mL

Artemisone Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Artemisone255730-18-8Artemifone BAY 44-9585ParasiteCMVCytomegalovirusInhibitorinhibitorinhibit

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Artemisone (Synonyms: Artemifone; BAY 44-9585)

Revisión del cliente

Other Forms of Artemisone:

Artemisone Related Antibodies

1 Publications Citing Use of MCE Artemisone

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Parasite:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Artemisone Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

Artemisone Related Classifications

Keywords:

Productos vistos recientemente:

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SAFETY DATA SHEET (SDS)

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