2. GPCR/G Protein
  3. Oxytocin Receptor Vasopressin Receptor
  4. Atosiban

アトシバン  (Synonyms: Atosiban; RW22164; RWJ22164)

製品番号: HY-17572 純度: 99.44%
COA 取扱説明書 Technical Support

Atosiban (RW22164; RWJ22164) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

カスタムペプチド

CAS 番号 : 90779-69-4

容量 価格（税別） 在庫状況 数量
5 mg $92 在庫あり
10 mg $158 在庫あり
25 mg $236 在庫あり
50 mg $290 在庫あり
100 mg $348 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 7 publication(s) in Google Scholar

Other Forms of Atosiban:

アトシバン 関連抗体

Top Publications Citing Use of Products

    Atosiban purchased from MedChemExpress. Usage Cited in: Neuron. 2026 Mar 26:S0896-6273(26)00120-0.  [Abstract]

    Representative traces and quantification of oEPSC amplitude with OXTR agonist (TGOT, red) or antagonist (Atosiban, blue). The results showed that during high-frequency stimulation (50 Hz), TGOT increased the amplitude of the first oEPSC, while Atosiban (1 μM) reduced it, indicating that OXTR activation strengthened synaptic transmission.

    Atosiban purchased from MedChemExpress. Usage Cited in: Curr Biol. 2025 Sep 26:S0960-9822(25)01182-0.  [Abstract]

    Atosiban (50 μM, 500 nL; bilaterally microinjected into the dorsal bed nucleus of the stria terminalis (dBNST)) administration induced anxiety-like behaviors, as evidenced by reduced exploratory activity in both the OF and EPM tests in sham-treated mice.

    Atosiban purchased from MedChemExpress. Usage Cited in: Neurosci Bull. 2025 Aug 6.  [Abstract]

    The icv injection of an oxytocin antagonist Atosiban (OTA, 5 mg/mL; i.c.v.) prevented mechanical allodynia in female cage-mate, female stranger, and male stranger rats; and the icv injection of oxytocin in male stranger rats induced mechanical allodynia after 30-min social interaction with painful CCI rats.

    Atosiban purchased from MedChemExpress. Usage Cited in: Neurosci Bull. 2025 Aug 6.  [Abstract]

    Immunofluorescence showing c-Fos-positive cells in the mPFC (as a control group) and ACC (aACC, mACC, and pACC) after icv injection of an oxytocin antagonist (Atosiban (OTA, 5 mg/mL; i.c.v.) ) in females or oxytocin in males after social interaction with painful CCI rats. Left: representative immunofluorescent staining images. Right: data summary. Tissues were collected immediately after 30-min social interaction (n = 6 rats).

    Atosiban purchased from MedChemExpress. Usage Cited in: Front Neurosci. 2021 Sep 10:15:723064.  [Abstract]

    The time spent in the social interaction zone was measured in the social interaction test. Pretreatment with atosiban (2.5 ng/μL; once daily for 5 days; injected into the medial prefrontal cortex (mPFC)) 30 min before each oxytocin infusion in the mPFC showed a trend of attenuation of the social interaction behavior, which was improved by oxytocin in ketamine-treated mice, although there was no significant difference between groups.

    Vasopressin Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    V1a Receptor  V1b Receptor  V2 Receptor 

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Atosiban (RW22164; RWJ22164) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research[1].

    体外実験

    Atosiban inhibits the oxytocin-mediated release of IP3 from the myometrial cell membrane. There is reduced release of intracellular, stored calcium from the sacroplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, Atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    アトシバン 関連抗体
    体内実験

    The posterior pituitary hormones, oxytocin and arginine vasopressin, differ in structure by only two amino acids, and Atosiban influences physiological effects of arginine vasopressin on the feto-maternal cardiovascular and renal systems. In late-gestation sheep, the administration of Atosiban for 1 hour fails to induce fetomaternal cardiovascular changes[1].
    Atosiban blocks the activation of oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    分子量

    994.19

    分子式

    C43H67N11O12S2
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Sealed storage, away from moisture
    Powder -80°C 2 years
      -20°C 1 year
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : ≥ 200 mg/mL (201.17 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 16.67 mg/mL (16.77 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.0058 mL 5.0292 mL 10.0584 mL
    5 mM 0.2012 mL 1.0058 mL 2.0117 mL
    10 mM 0.1006 mL 0.5029 mL 1.0058 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 1.67 mg/mL (1.68 mM); Clear solution

      This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 1.67 mg/mL (1.68 mM); Clear solution

      This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.44%

    COA (255 KB) RP-HPLC (109 KB) MS (179 KB) Elemental Analysis Report (114 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 1.0058 mL 5.0292 mL 10.0584 mL 25.1461 mL
    5 mM 0.2012 mL 1.0058 mL 2.0117 mL 5.0292 mL
    10 mM 0.1006 mL 0.5029 mL 1.0058 mL 2.5146 mL
    15 mM 0.0671 mL 0.3353 mL 0.6706 mL 1.6764 mL
    DMSO 20 mM 0.0503 mL 0.2515 mL 0.5029 mL 1.2573 mL
    25 mM 0.0402 mL 0.2012 mL 0.4023 mL 1.0058 mL
    30 mM 0.0335 mL 0.1676 mL 0.3353 mL 0.8382 mL
    40 mM 0.0251 mL 0.1257 mL 0.2515 mL 0.6287 mL
    50 mM 0.0201 mL 0.1006 mL 0.2012 mL 0.5029 mL
    60 mM 0.0168 mL 0.0838 mL 0.1676 mL 0.4191 mL
    80 mM 0.0126 mL 0.0629 mL 0.1257 mL 0.3143 mL
    100 mM 0.0101 mL 0.0503 mL 0.1006 mL 0.2515 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Atosiban Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Atosiban90779-69-4RW22164 RWJ22164RW 22164RW-22164RWJ22164RWJ 22164RWJ-22164Oxytocin ReceptorVasopressin ReceptorOXTRPretermmaternal-fetaloxytocinnonapeptidedesamino-oxytocintocolyticCa2+vasopressinInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
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