1. GPCR/G Protein
  2. Oxytocin Receptor
    Vasopressin Receptor
  3. Atosiban acetate

Atosiban acetate (Synonyms: RW22164 acetate; RWJ22164 acetate)

Cat. No.: HY-17572A Purity: 99.92%
Handling Instructions

Atosiban acetate (RW22164 acetate;RWJ22164 acetate) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research.

For research use only. We do not sell to patients.

Atosiban acetate Chemical Structure

Atosiban acetate Chemical Structure

CAS No. : 914453-95-5

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Based on 1 publication(s) in Google Scholar

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Description

Atosiban acetate (RW22164 acetate;RWJ22164 acetate) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research[1].

In Vitro

Atosiban inhibits the oxytocin-mediated release of IP3 from the myometrial cell membrane. There is reduced release of intracellular, stored calcium from the sacroplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, Atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua[1].

In Vivo

The posterior pituitary hormones, oxytocin and arginine vasopressin, differ in structure by only two amino acids, and Atosiban influences physiological effects of arginine vasopressin on the feto-maternal cardiovascular and renal systems. In late-gestation sheep, the administration of Atosiban for 1 hour fails to induce fetomaternal cardiovascular changes[1].
Atosiban blocks the activation of oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice[2].

Molecular Weight

1054.24

Formula

C₄₅H₇₁N₁₁O₁₄S₂

CAS No.

914453-95-5

SMILES

O=C([[email protected]](CSSCCC(N[[email protected]@H](C1=O)CC2=CC=C(OCC)C=C2)=O)NC([[email protected]@H](NC(C(NC([[email protected]](N1)([H])[[email protected]@H](C)CC)=O)[[email protected]](O)C)=O)CC(N)=O)=O)N(CCC3)[[email protected]@H]3C(N[[email protected]@H](CCCN)C(NCC(N)=O)=O)=O.OC(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

References
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Keywords:

AtosibanRW22164RWJ22164RW 22164RW-22164RWJ 22164RWJ-22164Oxytocin ReceptorVasopressin ReceptorOXTRPretermmaternal-fetaloxytocinnonapeptidedesamino-oxytocintocolyticCa2+vasopressinInhibitorinhibitorinhibit

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Atosiban acetate
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