1. GPCR/G Protein
  2. Oxytocin Receptor
    Vasopressin Receptor
  3. Atosiban acetate

Atosiban acetate (Synonyms: RW22164 acetate; RWJ22164 acetate)

Cat. No.: HY-17572A Purity: 99.92%
Handling Instructions

Atosiban acetate (RW22164 acetate;RWJ22164 acetate) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research.

For research use only. We do not sell to patients.

Atosiban acetate Chemical Structure

Atosiban acetate Chemical Structure

CAS No. : 914453-95-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 167 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 264 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Atosiban acetate (RW22164 acetate;RWJ22164 acetate) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research[1].

In Vitro

Atosiban inhibits the oxytocin-mediated release of IP3 from the myometrial cell membrane. There is reduced release of intracellular, stored calcium from the sacroplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, Atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The posterior pituitary hormones, oxytocin and arginine vasopressin, differ in structure by only two amino acids, and Atosiban influences physiological effects of arginine vasopressin on the feto-maternal cardiovascular and renal systems. In late-gestation sheep, the administration of Atosiban for 1 hour fails to induce fetomaternal cardiovascular changes[1].
Atosiban blocks the activation of oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

1054.24

Formula

C₄₅H₇₁N₁₁O₁₄S₂

CAS No.

914453-95-5

SMILES

O=C([[email protected]](CSSCCC(N[[email protected]@H](C1=O)CC2=CC=C(OCC)C=C2)=O)NC([[email protected]@H](NC(C(NC([[email protected]](N1)([H])[[email protected]@H](C)CC)=O)[[email protected]](O)C)=O)CC(N)=O)=O)N(CCC3)[[email protected]@H]3C(N[[email protected]@H](CCCN)C(NCC(N)=O)=O)=O.OC(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (94.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9486 mL 4.7428 mL 9.4855 mL
5 mM 0.1897 mL 0.9486 mL 1.8971 mL
10 mM 0.0949 mL 0.4743 mL 0.9486 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.37 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.37 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.37 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.92%

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Keywords:

AtosibanRW22164RWJ22164RW 22164RW-22164RWJ 22164RWJ-22164Oxytocin ReceptorVasopressin ReceptorOXTRPretermmaternal-fetaloxytocinnonapeptidedesamino-oxytocintocolyticCa2+vasopressinInhibitorinhibitorinhibit

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Atosiban acetate
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HY-17572A
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