1. GPCR/G Protein
  2. Oxytocin Receptor
    Vasopressin Receptor
  3. Atosiban

Atosiban (Synonyms: RW22164; RWJ22164)

Cat. No.: HY-17572 Purity: 99.09%
Handling Instructions

Atosiban (RW22164; RWJ22164) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research.

For research use only. We do not sell to patients.

Atosiban Chemical Structure

Atosiban Chemical Structure

CAS No. : 90779-69-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 157 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 264 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Atosiban (RW22164; RWJ22164) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research[1].

In Vitro

Atosiban inhibits the oxytocin-mediated release of IP3 from the myometrial cell membrane. There is reduced release of intracellular, stored calcium from the sacroplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, Atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The posterior pituitary hormones, oxytocin and arginine vasopressin, differ in structure by only two amino acids, and Atosiban influences physiological effects of arginine vasopressin on the feto-maternal cardiovascular and renal systems. In late-gestation sheep, the administration of Atosiban for 1 hour fails to induce fetomaternal cardiovascular changes[1].
Atosiban blocks the activation of oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

994.19

Formula

C₄₃H₆₇N₁₁O₁₂S₂

CAS No.

90779-69-4

SMILES

O=C([[email protected]](CSSCCC(N[[email protected]@H](C1=O)CC2=CC=C(OCC)C=C2)=O)NC([[email protected]@H](NC(C(NC([[email protected]](N1)([H])[[email protected]@H](C)CC)=O)[[email protected]](O)C)=O)CC(N)=O)=O)N(CCC3)[[email protected]@H]3C(N[[email protected]@H](CCCN)C(NCC(N)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 16.67 mg/mL (16.77 mM; Need ultrasonic)

DMSO : ≥ 16.67 mg/mL (16.77 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0058 mL 5.0292 mL 10.0584 mL
5 mM 0.2012 mL 1.0058 mL 2.0117 mL
10 mM 0.1006 mL 0.5029 mL 1.0058 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (1.68 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (1.68 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (1.68 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AtosibanRW22164 RWJ22164RW 22164RW-22164RWJ22164RWJ 22164RWJ-22164Oxytocin ReceptorVasopressin ReceptorOXTRPretermmaternal-fetaloxytocinnonapeptidedesamino-oxytocintocolyticCa2+vasopressinInhibitorinhibitorinhibit

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Atosiban
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