Chlorothiazide

Name: Chlorothiazide
Brand: MedChemExpress
SKU: HY-B0224
Rating: 5.0 (3 reviews)

Art. -Nr.: HY-B0224 Reinheit: 98.96%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Chlorothiazide is an orally active diuretic and anti-hypertensive agent.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Chlorothiazide Chemische Struktur

CAS. Nr. : 58-94-6

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
100 mg	Auf Lager	Estimated Time of Arrival: December 31
500 mg	Auf Lager	Estimated Time of Arrival: December 31
1 g	Angebot einholen
5 g	Angebot einholen

or Massenanfrage

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This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 3 publication(s) in Google Scholar

Other Forms of Chlorothiazide:

Chlorothiazide (Standard) In-stock
Chlorothiazide-¹³C,¹⁵N₂ Angebot einholen
Chlorothiazide sodium Angebot einholen

3 Publications Citing Use of MCE Chlorothiazide

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Protokoll
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

Chlorothiazide is an orally active diuretic and anti-hypertensive agent^[1].

In Vitro

Chlorothiazide has a plasma half-life of 45–120 min and a biological half-life of nearly 10 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Klinische Studie

Molekulargewicht

295.73

Formel

C₇H₆ClN₃O₄S₂

CAS. Nr.

58-94-6

Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=C(Cl)C=C(C2=C1)N=CNS2(=O)=O)(N)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (338.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3815 mL	16.9074 mL	33.8147 mL
5 mM	0.6763 mL	3.3815 mL	6.7629 mL
10 mM	0.3381 mL	1.6907 mL	3.3815 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3.5 mg/mL (11.84 mM); Clear solution

This protocol yields a clear solution of ≥ 3.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (35.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 3.5 mg/mL (11.84 mM); Clear solution

This protocol yields a clear solution of ≥ 3.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (35.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 3.5 mg/mL (11.84 mM); Clear solution

This protocol yields a clear solution of ≥ 3.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (35.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Reinheit & Dokumentation

Purity: 98.96%

Select Batch:

Data Sheet (276 KB) SDS (419 KB)

COA (254 KB) HNMR (133 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Babu V R, et al. Preparation and in-vitro release of chlorothiazide novel pH-sensitive chitosan-N, N′-dimethylacrylamide semi-interpenetrating network microspheres. Carbohydrate Polymers, 2008, 71(2): 208-217.

Zellassay	MCE hat die Genauigkeit dieser Methoden nicht unabhängig bestätigt. Sie dienen nur als Referenz.
Verweise	[1]. Babu V R, et al. Preparation and in-vitro release of chlorothiazide novel pH-sensitive chitosan-N, N′-dimethylacrylamide semi-interpenetrating network microspheres. Carbohydrate Polymers, 2008, 71(2): 208-217.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3815 mL	16.9074 mL	33.8147 mL	84.5369 mL
	5 mM	0.6763 mL	3.3815 mL	6.7629 mL	16.9074 mL
	10 mM	0.3381 mL	1.6907 mL	3.3815 mL	8.4537 mL
	15 mM	0.2254 mL	1.1272 mL	2.2543 mL	5.6358 mL
	20 mM	0.1691 mL	0.8454 mL	1.6907 mL	4.2268 mL
	25 mM	0.1353 mL	0.6763 mL	1.3526 mL	3.3815 mL
	30 mM	0.1127 mL	0.5636 mL	1.1272 mL	2.8179 mL
	40 mM	0.0845 mL	0.4227 mL	0.8454 mL	2.1134 mL
	50 mM	0.0676 mL	0.3381 mL	0.6763 mL	1.6907 mL
	60 mM	0.0564 mL	0.2818 mL	0.5636 mL	1.4089 mL
	80 mM	0.0423 mL	0.2113 mL	0.4227 mL	1.0567 mL
	100 mM	0.0338 mL	0.1691 mL	0.3381 mL	0.8454 mL

Chlorothiazide Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chlorothiazide58-94-6Renindiureticanti-hypertensiveorally activeInhibitorinhibitorinhibit

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Chlorothiazide

Kundenbewertung

Other Forms of Chlorothiazide:

Chlorothiazide Related Antibodies

3 Publications Citing Use of MCE Chlorothiazide

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität

Protokoll

Reinheit & Dokumentation

Verweise

Kundenbewertung

Chlorothiazide Related Antibodies

Molaritätsrechner

Verdünnungsrechner

Complete Stock Solution Preparation Table

Chlorothiazide Related Classifications

Keywords:

Ihre kürzlich angesehenen Produkte:

Kundenbewertung

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report