2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. Danirixin

Danirixin  (Synonyms: GSK1325756)

製品番号: HY-19768 純度: 98.45%
COA 取扱説明書

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Danirixin is a selective, and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8.

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Danirixin 構造式

Danirixin 構造式

CAS 番号 : 954126-98-8

容量 価格（税別） 在庫状況 数量
1 mg USD 100 在庫あり
5 mg USD 300 在庫あり
10 mg USD 425 在庫あり
50 mg USD 1300 在庫あり
100 mg USD 1750 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 6 publication(s) in Google Scholar

Danirixin 関連抗体

Top Publications Citing Use of Products

CXCR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

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製品説明

Danirixin is a selective, and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8.

IC50 & Target[1]

CXCL8-CXCR2

12.5 nM (IC50)

体外実験

Danirixin is a small molecule, CXCR2 antagonist being evaluated as a potential anti-inflammatory medicine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Danirixin 関連抗体
臨床実験
分子量

441.90

分子式

C19H21ClFN3O4S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(Cl)C(S([C@H]2CCCNC2)(=O)=O)=C1O)NC3=C(C)C(F)=CC=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 8 mg/mL (18.10 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2630 mL 11.3148 mL 22.6296 mL
5 mM 0.4526 mL 2.2630 mL 4.5259 mL
10 mM 0.2263 mL 1.1315 mL 2.2630 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2630 mL 11.3148 mL 22.6296 mL 56.5739 mL
5 mM 0.4526 mL 2.2630 mL 4.5259 mL 11.3148 mL
10 mM 0.2263 mL 1.1315 mL 2.2630 mL 5.6574 mL
15 mM 0.1509 mL 0.7543 mL 1.5086 mL 3.7716 mL
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Danirixin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Danirixin954126-98-8GSK1325756GSK 1325756GSK-1325756CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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製品名:
Danirixin
製品番号:
HY-19768
数量:
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