2. Membrane Transporter/Ion Channel
  3. SGLT
  4. Dapagliflozin ((2S)-1,2-propanediol, hydrate)

Dapagliflozin ((2S)-1,2-propanediol, hydrate)  (Synonyms: BMS-512148 (2S)-1,2-propanediol, hydrate)

Cat. No.: HY-10450A Purity: 99.95%
COA Handling Instructions

Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin ((2S)-1,2-propanediol, hydrate), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine. Dapagliflozin ((2S)-1,2-propanediol, hydrate) induces HIF1 expression and attenuates renal IR injury.

For research use only. We do not sell to patients.

Dapagliflozin ((2S)-1,2-propanediol, hydrate) Chemical Structure

Dapagliflozin ((2S)-1,2-propanediol, hydrate) Chemical Structure

CAS No. : 960404-48-2

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 61 In-stock
Solid
5 mg USD 55 In-stock
10 mg USD 77 In-stock
50 mg USD 121 In-stock
100 mg USD 154 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 32 publication(s) in Google Scholar

Other Forms of Dapagliflozin ((2S)-1,2-propanediol, hydrate):

Top Publications Citing Use of Products

    Dapagliflozin ((2S)-1,2-propanediol, hydrate) purchased from MCE. Usage Cited in: Life Sci. 2023 Apr 4;121671.  [Abstract]

    Dapagliflozin (DAPA; 10 μM; 24 hours) significantly decreases the expression of YAP/TAZ and increases the ratios of p-YAP/YAP and pTAZ/TAZ under high glucose conditions in HK-2 cells.

    Dapagliflozin ((2S)-1,2-propanediol, hydrate) purchased from MCE. Usage Cited in: Life Sci. 2023 Apr 4;121671.  [Abstract]

    Dapagliflozin (DAPA; 10 μM; 24 hours) significantly reduces the high glucose-induced increase in YAP/TAZ expression in HK-2 cells.

    Dapagliflozin ((2S)-1,2-propanediol, hydrate) purchased from MCE. Usage Cited in: Life Sci. 2023 Apr 4;121671.  [Abstract]

    Dapagliflozin (DAPA; 10, 20 μM; 24 h) significantly reverses the decrease in cell viability caused by high glucose in HK-2 cells.

    Dapagliflozin ((2S)-1,2-propanediol, hydrate) purchased from MCE. Usage Cited in: EBioMedicine. 2022, 86: 104342.

    Dapagliflozin increases the LC3-II to LC3-I expression ratio in the liver.

    Dapagliflozin ((2S)-1,2-propanediol, hydrate) purchased from MCE. Usage Cited in: Biochem Pharmacol. 2018 Jun;152:45-59.  [Abstract]

    Effects of Dapagliflozin and Empagliflozin on p62 expression in LPS-untreated and LPS-treated RAW264.7 cells.

    Dapagliflozin ((2S)-1,2-propanediol, hydrate) purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2018;45(5):1747-1758.  [Abstract]

    The expression of IRS1 significantly decreases. The phosphorylation levels of Akt1, Akt2, and S6 are significantly reduced in livers of db/db mice.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin ((2S)-1,2-propanediol, hydrate), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine[1]. Dapagliflozin ((2S)-1,2-propanediol, hydrate) induces HIF1 expression and attenuates renal IR injury[2].

    IC50 & Target

    SGLT2

     

    In Vitro

    Dapagliflozin ((2S)-1,2-propanediol, hydrate) (0-10 μM; 24 hours) significantly increases the cell survival in hypoxic HK2 cell in a dose-dependent manner[2].
    Dapagliflozin ((2S)-1,2-propanediol, hydrate) (0-10 μM; 2 hours) increases the HIF1 expression, increases AMPK and EKR phosphorylation in hypoxic HK2 cells, but shows no effect on the phosphorylation of AMPK and ERK in normoxic HK2 cells[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: Hypoxic HK2 cell
    Concentration: 0 μM, 1 μM, 2 μM, 5 μM, 10 μM
    Incubation Time: 24 hours
    Result: Improved the cell viability in a dose-dependent manner compared with control cells.

    Western Blot Analysis[1]

    Cell Line: Hypoxic HK2 cell, Normoxic HK2 cells
    Concentration: 0 μM, 1 μM, 2 μM, 5 μM, 10 μM
    Incubation Time: 24 hours
    Result: Induced HIF1 expression in hypoxic and normoxic HK2 cells.
    Clinical Trial
    Molecular Weight

    502.98

    Appearance

    Solid

    Formula

    C24H35ClO9
    CAS No.
    SMILES

    O[[email protected]]1[[email protected]](C2=CC(CC3=CC=C(OCC)C=C3)=C(Cl)C=C2)O[[email protected]](CO)[[email protected]@H](O)[[email protected]@H]1O.C[[email protected]](O)CO.O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (198.82 mM)

    H2O : 2.38 mg/mL (4.73 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9882 mL 9.9408 mL 19.8815 mL
    5 mM 0.3976 mL 1.9882 mL 3.9763 mL
    10 mM 0.1988 mL 0.9941 mL 1.9882 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.97 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.97 mM); Clear solution

    • 3.

      Add each solvent one by one:  PBS

      Solubility: 2.5 mg/mL (4.97 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    • 4.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (4.14 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.99%

    COA (251 KB) HNMR (208 KB) RP-HPLC (327 KB) LCMS (278 KB)

    Handling Instructions (2659 KB)
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Dapagliflozin ((2S)-1,2-propanediol, hydrate)960404-48-2BMS-512148 (2S)-1,2-propanediol,SGLTSodium-dependent glucose cotransportersInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Salutation

    Applicant Name *

    		 

    Email address *

    Phone number *

    		 

    Organization name *

    Department *

    		 

    Requested quantity *

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Dapagliflozin ((2S)-1,2-propanediol, hydrate)
    Cat. No.:
    HY-10450A
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email address *

    Phone number

    		 

    Department *

    Organization name *

    		 

    Country or Region *

    Remarks

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.