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Dapagliflozin ((2S)-1,2-propanediol, hydrate)

(Synonyms: BMS-512148 (2S)-1,2-propanediol, hydrate)
72 Cited Publications
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Based on 72 publication(s) in Google Scholar

Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin ((2S)-1,2-propanediol, hydrate), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine. Dapagliflozin ((2S)-1,2-propanediol, hydrate) induces HIF1 expression and attenuates renal IR injury.

For research use only. We do not sell to patients.

  • Purity : 99.97%
  • CAS No.: 960404-48-2
  • Formula: C24H35ClO9
  • Molecular Weight:502.98
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

  • Dapagliflozin ((2S)-1,2-propanediol, hydrate) Chemical Structure
    Dapagliflozin ((2S)-1,2-propanediol, hydrate) Chemical Structure
  • Experimental Validation Results for Dapagliflozin ((2S)-1,2-propanediol, hydrate)
  • Experimental Validation Results for Dapagliflozin ((2S)-1,2-propanediol, hydrate)
  • Experimental Validation Results for Dapagliflozin ((2S)-1,2-propanediol, hydrate)
  • Experimental Validation Results for Dapagliflozin ((2S)-1,2-propanediol, hydrate)
  • Experimental Validation Results for Dapagliflozin ((2S)-1,2-propanediol, hydrate)
  • Experimental Validation Results for Dapagliflozin ((2S)-1,2-propanediol, hydrate)
CAS No.: 960404-48-2
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WBCell Proliferation/Viability AssayIF
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  • Dapagliflozin ((2S)-1,2-propanediol, hydrate) Chemical Structure
    Dapagliflozin ((2S)-1,2-propanediol, hydrate) Chemical Structure
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    Dapagliflozin ((2S)-1,2-propanediol, hydrate) purchased from MedChemExpress. Usage Cited in: Life Sci. 2023 Jun 1:322:121671. [Abstract]

    Customer Validation
     Dapagliflozin (DAPA; 10, 20 μM; 24 h) significantly reverses the decrease in cell viability caused by high glucose in HK-2 cells.

  • 1/16

    Dapagliflozin ((2S)-1,2-propanediol, hydrate) purchased from MedChemExpress. Usage Cited in: Life Sci. 2023 Jun 1:322:121671. [Abstract]

    Customer Validation
     Dapagliflozin (DAPA; 10 μM; 24 hours) significantly reduces the high glucose-induced increase in YAP/TAZ expression in HK-2 cells.

  • 1/16

    Dapagliflozin ((2S)-1,2-propanediol, hydrate) purchased from MedChemExpress. Usage Cited in: Life Sci. 2023 Jun 1:322:121671. [Abstract]

    Customer Validation
     Dapagliflozin (DAPA; 10 μM; 24 hours) significantly decreases the expression of YAP/TAZ and increases the ratios of p-YAP/YAP and pTAZ/TAZ under high glucose conditions in HK-2 cells.

  • 1/16

    Dapagliflozin ((2S)-1,2-propanediol, hydrate) purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2022 Dec:86:104342. [Abstract]

    Customer Validation
     Dapagliflozin increases the LC3-II to LC3-I expression ratio in the liver.

  • 1/16

    Dapagliflozin ((2S)-1,2-propanediol, hydrate) purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2018 Jun:152:45-59. [Abstract]

    Customer Validation
     Effects of Dapagliflozin and Empagliflozin on p62 expression in LPS-untreated and LPS-treated RAW264.7 cells.

  • 1/16

    Dapagliflozin ((2S)-1,2-propanediol, hydrate) purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2018;45(5):1747-1758. [Abstract]

    Customer Validation
     The expression of IRS1 significantly decreases. The phosphorylation levels of Akt1, Akt2, and S6 are significantly reduced in livers of db/db mice.

  • Dapagliflozin ((2S)-1,2-propanediol, hydrate)