1. Membrane Transporter/Ion Channel
  2. SGLT
  3. Dapagliflozin ((2S)-1,2-propanediol, hydrate)

Dapagliflozin ((2S)-1,2-propanediol, hydrate) (Synonyms: BMS-512148 (2S)-1,2-propanediol, hydrate)

Cat. No.: HY-10450A Purity: 99.97%
Handling Instructions

Dapagliflozin (2S)-1,2-propanediol, hydrate is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin inhibits sodium/glucose cotransporter 2 (SGLT2), which results in excretion of glucose into the urine.

For research use only. We do not sell to patients.

Dapagliflozin ((2S)-1,2-propanediol, hydrate) Chemical Structure

Dapagliflozin ((2S)-1,2-propanediol, hydrate) Chemical Structure

CAS No. : 960404-48-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 110 In-stock
Estimated Time of Arrival: December 31
100 mg USD 140 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Other Forms of Dapagliflozin ((2S)-1,2-propanediol, hydrate):

Top Publications Citing Use of Products

    Dapagliflozin ((2S)-1,2-propanediol, hydrate) purchased from MCE. Usage Cited in: Biochem Pharmacol. 2018 Jun;152:45-59.

    Effects of Dapagliflozin and Empagliflozin on p62 expression in LPS-untreated and LPS-treated RAW264.7 cells.

    Dapagliflozin ((2S)-1,2-propanediol, hydrate) purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2018;45(5):1747-1758.

    The expression of IRS1 significantly decreases. The phosphorylation levels of Akt1, Akt2, and S6 are significantly reduced in livers of db/db mice.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    Description

    Dapagliflozin (2S)-1,2-propanediol, hydrate is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin inhibits sodium/glucose cotransporter 2 (SGLT2), which results in excretion of glucose into the urine.

    Clinical Trial
    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (198.82 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9882 mL 9.9408 mL 19.8815 mL
    5 mM 0.3976 mL 1.9882 mL 3.9763 mL
    10 mM 0.1988 mL 0.9941 mL 1.9882 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.97 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.97 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.97 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    Molecular Weight

    502.98

    Formula

    C₂₄H₃₅ClO₉

    CAS No.

    960404-48-2

    SMILES

    O[[email protected]]1[[email protected]](C2=CC(CC3=CC=C(OCC)C=C3)=C(Cl)C=C2)O[[email protected]](CO)[[email protected]@H](O)[[email protected]@H]1O.C[[email protected]](O)CO.O

    Shipping

    Room temperature in continental US; may vary elsewhere

    • SGLT2 inhibitor
    • Molarity Calculator

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    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Product Name:
    Dapagliflozin ((2S)-1,2-propanediol, hydrate)
    Cat. No.:
    HY-10450A
    Quantity:

    Dapagliflozin ((2S)-1,2-propanediol, hydrate)

    Cat. No.: HY-10450A