2. GPCR/G Protein Cytoskeleton
  3. Endothelin Receptor Integrin
  4. Endothelin-3, human, mouse, rabbit, rat

Endothelin-3, human, mouse, rabbit, rat  (Synonyms: Endothelin 3 (Rat,Human))

Cat. No.: HY-P0204 Purity: 97.58%
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Endothelin-3, human, mouse, rabbit, rat (Endothelin 3 (Rat,Human)) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat can be used in studies related to distal aganglionosis.

For research use only. We do not sell to patients.

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Endothelin-3, human, mouse, rabbit, rat

Endothelin-3, human, mouse, rabbit, rat Chemical Structure

CAS No. : 117399-93-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Endothelin-3, human, mouse, rabbit, rat:

Endothelin-3, human, mouse, rabbit, rat Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Endothelin-3, human, mouse, rabbit, rat

View All Endothelin Receptor Isoform Specific Products:

View All Isoforms
ETA ETB

View All Integrin Isoform Specific Products:

View All Isoforms
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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  • Purity & Documentation

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  • Customer Review

Description

Endothelin-3, human, mouse, rabbit, rat (Endothelin 3 (Rat,Human)) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat can be used in studies related to distal aganglionosis[1].

IC50 & Target

β1-integrin[1]
In Vitro

Endothelin-3, human, mouse, rabbit, rat (100 nM-1 μM) significantly enhances the adhesion capacity of mouse E12.5 YFP-labeled enteric neural crest cells cultured on fibronectin, increases the number and size of focal adhesions, and promotes the formation of lamellipodia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Endothelin-3, human, mouse, rabbit, rat Related Antibodies
Molecular Weight

2643.04

Formula

C121H168N26O33S4
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp(Disulfide bridge: Cys1-Cys15, Cys3-Cys11)
Sequence Shortening

CTCFTYKDKECVYYCHLDIIW(Disulfide bridge: Cys1-Cys15, Cys3-Cys11)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (18.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3784 mL 1.8918 mL 3.7835 mL
5 mM 0.0757 mL 0.3784 mL 0.7567 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3784 mL 1.8918 mL 3.7835 mL 9.4588 mL
5 mM 0.0757 mL 0.3784 mL 0.7567 mL 1.8918 mL
10 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.9459 mL
15 mM 0.0252 mL 0.1261 mL 0.2522 mL 0.6306 mL
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Endothelin-3, human, mouse, rabbit, rat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Endothelin-3, human, mouse, rabbit, rat117399-93-6Endothelin 3 (Rat,Human)Endothelin ReceptorIntegrinInhibitorinhibitorinhibit

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