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  4. Etanercept

Etanercept  (Synonyms: エタネルセプト)

製品番号: HY-108847 純度: 99.20%
COA Technical Support

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.

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CAS 番号 : 185243-69-0

容量 価格（税別） 在庫状況 数量
>無料サンプル (100 μg)   今すぐ申し込む  
1 mg $400 在庫あり
5 mg $800 在庫あり
10 mg $1080 在庫あり
50 mg $2160 在庫あり
100 mg   お問い合わせ  
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カスタマーレビュー

Based on 15 publication(s) in Google Scholar

Etanercept Featured Recommendations:

Etanercept 関連抗体

Top Publications Citing Use of Products

    Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31.  [Abstract]

    Evaluation of arthritis scores for non-immunized (NI) mice or CIA mice in different treatment groups. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.

    Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31.  [Abstract]

    Representative micro-CT images of the mice in different groups. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.

    Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31.  [Abstract]

    Images of H&E and SafO-FG staining of the paw sections. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.

    Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31.  [Abstract]

    Measurement of BS/BV, and quantification of synovial inflammation and bone erosion on H&E-stained sections, as well as cartilage erosion on SafO-FG-stained sections. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.

    Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31.  [Abstract]

    Immunofluorescence staining of FOXK1, STAT1, STAT2, IL-6, IL-1β and MMP3 on sections of paws of the mice in different groups. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.

    TNF Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

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    製品説明

    Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis[1][2][3].

    IC50 & Target[1][2]

    Fas

     

    体内実験

    Etanercept (10 mg/kg; s.c.; every 3 days for 3 weeks) significantly decreases the mean arthritis scores and radiological score[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Six-week-old male Lewis rats (adjuvant-induced arthritis (AIA) model)[4]
    Dosage: 10 mg/kg
    Administration: S.c.; every 3 days for 3 weeks
    Result: Significantly decreased the mean arthritis scores; Significant decreased in radiological score at the end of the treatment period.
    臨床実験
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    分子量

    102.5 kDa

    CAS 番号
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Etanercept]
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    保管条件

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • [TNFRSF1B (tumor necrosis factor receptor (TNFR)superfamily member 1B, TNFBR, p75, CD120b)]2-IGHG1 Fc (Fragment constant)
    Biological Activity
    • Immobilized TNF-alpha/TNFSF2 Protein, Human (His, HY-P7416) can bind Etanercept. The EC50 for this effect is 9.44 ng/mL.
    純度とドキュメンテーション

    純度: 99.20%

    COA (231 KB)

    Inhibitory Antibodies User Guide (603 KB)
    参考文献
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Etanercept Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Etanercept185243-69-0TNF ReceptorBacterialTumor Necrosis Factor ReceptorTNFRrheumatoidarthritissolublereceptorcellsurfaceproinflammatorycytokineInhibitorinhibitorinhibit

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    製品名:
    Etanercept
    製品番号:
    HY-108847
    数量:
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