Etanercept

Name: Etanercept
Brand: MedChemExpress
SKU: HY-108847
Rating: 5.0 (15 reviews)

Art. -Nr.: HY-108847 Reinheit: 99.20%: Data Sheet
COA

SDS

FAQs
Technical Support

Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr. : 185243-69-0

Größe	Verfügbarkeit	Menge
Kostenlose Probe (100 μg)	Jetzt bewerben
Kostenlose Probe (100 μg)	Jetzt bewerben
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Angebot einholen
200 mg	Angebot einholen

or Massenanfrage

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 15 publication(s) in Google Scholar

Etanercept Spezialitätsempfehlungen:

15 Publications Citing Use of MCE Etanercept

In Vivo Efficacy Study

In Vivo Imaging

Histological Imaging/Staining

: Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31. [Abstract]; Evaluation of arthritis scores for non-immunized (NI) mice or CIA mice in different treatment groups. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.

: Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31. [Abstract]; Representative micro-CT images of the mice in different groups. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.

: Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31. [Abstract]; Images of H&E and SafO-FG staining of the paw sections. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.

: Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31. [Abstract]; Measurement of BS/BV, and quantification of synovial inflammation and bone erosion on H&E-stained sections, as well as cartilage erosion on SafO-FG-stained sections. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.

: Etanercept purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 May 23;12(1):31. [Abstract]; Immunofluorescence staining of FOXK1, STAT1, STAT2, IL-6, IL-1β and MMP3 on sections of paws of the mice in different groups. Etanercept (i.p., 5 mg/kg) twice every week for 5 weeks.

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle TNF Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

IC₅₀ & Target^[1]^[2]

Fas

In Vivo

Etanercept (10 mg/kg; s.c.; every 3 days for 3 weeks) significantly decreases the mean arthritis scores and radiological score^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Six-week-old male Lewis rats (adjuvant-induced arthritis (AIA) model)^[4]
Dosage:	10 mg/kg
Administration:	S.c.; every 3 days for 3 weeks
Result:	Significantly decreased the mean arthritis scores; Significant decreased in radiological score at the end of the treatment period.

Klinische Studie

Application

ELISA, FACS, Functional assay

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molekulargewicht

102.5 kDa

CAS. Nr.

185243-69-0

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Etanercept]

Formulation

Please refer to the lot-specific COA for specific buffer information.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Format

[TNFRSF1B (tumor necrosis factor receptor (TNFR)superfamily member 1B, TNFBR, p75, CD120b)]2-IGHG1 Fc (Fragment constant)

Biological Activity

Immobilized TNF-alpha/TNFSF2 Protein, Human (His, HY-P7416) can bind Etanercept. The EC₅₀ for this effect is 9.44 ng/mL.

Reinheit & Dokumentation

Purity: 99.20%

Select Batch:

Data Sheet (261 KB) SDS (419 KB)

COA (231 KB)

Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Goffe B, et al. Etanercept: An overview. J Am Acad Dermatol. 2003;49(2 Suppl):S105-S111. [Content Brief]

[2]. Goldenberg MM. Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis. Clin Ther. 1999;21(1):75-2. [Content Brief]

[3]. Haraoui B, et al. Etanercept in the treatment of rheumatoid arthritis. Ther Clin Risk Manag. 2007;3(1):99-105. [Content Brief]

[4]. Totoson P, et al. Etanercept improves endothelial function via pleiotropic effects in rat adjuvant-induced arthritis. Rheumatology (Oxford). 2016;55(7):1308-1317. [Content Brief]

Etanercept Related Classifications

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etanercept185243-69-0TNF ReceptorBacterialTumor Necrosis Factor ReceptorTNFRrheumatoidarthritissolublereceptorcellsurfaceproinflammatorycytokineInhibitorinhibitorinhibit

Ihre kürzlich angesehenen Produkte:

Produktname

Requested Quantity *

Name des Antragstellers *

Anrede

E-Mail-Addresse *

Telefonnummer *

Department

Name der Organisation *

City

Bundesland

Country or Region *

Bemerkungen

Produktname

Lot #

Name des Antragstellers *

E-Mail-Addresse *

Telefonnummer

Department *

Name der Organisation *

Country or Region *

Bemerkungen

Name
Email *

	Sorry, but the email address you supplied was invalid.

Etanercept

Kundenbewertung

Etanercept Spezialitätsempfehlungen:

Etanercept Related Antibodies

15 Publications Citing Use of MCE Etanercept

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle TNF Receptor Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

Etanercept Related Classifications

Molaritätsrechner

Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

The dilution calculator equation

Keywords:

Ihre kürzlich angesehenen Produkte:

Kundenbewertung

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report