1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. NKCC
    GABA Receptor
  3. Furosemide sodium

Furosemide sodium 

Cat. No.: HY-B0135A Purity: 99.69%
Handling Instructions

Furosemide sodium is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema.

For research use only. We do not sell to patients.

Furosemide sodium Chemical Structure

Furosemide sodium Chemical Structure

CAS No. : 41733-55-5

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10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
500 mg USD 90 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Furosemide sodium is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2[1]. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2].

IC50 & Target

IC50: NKCC1 and NKCC2[1]
IC50: GABAA receptors[2]

In Vitro

Furosemide sodium (500 µM; 72-96 hours) significantly changes the proliferation rates in MKN45 cells (the poorly differentiated human gastric adenocarcinoma cell line). however, it has no effects on MKN28 cells (the moderately differentiated human gastric adenocarcinoma cell line). The growth rate of MKN45 cells is larger than that of MKN28 cells[4].
Furosemide sodium (10 µM, 30 µM, 100 µM; 45 min exposure)significantly decreases cation channel activity and [Ca(2+)](i) in human erythrocytes drawn from healthy individuals. Tert-butylhydroperoxide similarly enhances the non-selective cation channels activity, increases [Ca(2+)](i) and triggered cell membrane scrambling, however, the effects is significantly blunted by Furosemide sodium again[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Furosemide sodium (intraperitoneal injection; 100 mg/kg; single dose) is injected after kanamycin (KM) (1000 mg/kg) to creat a deaf mouse model in C57BL/6 mouse. After injection, hearing loss and cochlear hair cell damage are evaluated on day 1, day 2 and day 3, respectively. The hearing is markedly deteriorated even from the next day (Day-1 group), OHCs (outer hair cell) morphology of apical, middle and basal turns are disorganized in mice on day3[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

352.73

Formula

C₁₂H₁₀ClN₂NaO₅S

CAS No.

41733-55-5

SMILES

O=C(C1=CC(S(=O)(N)=O)=C(C=C1NCC2=CC=CO2)Cl)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (425.25 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8350 mL 14.1751 mL 28.3503 mL
5 mM 0.5670 mL 2.8350 mL 5.6701 mL
10 mM 0.2835 mL 1.4175 mL 2.8350 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.09 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

FurosemideNKCCGABA ReceptorNa-K-Cl cotransporterNa(+)-K(+)-Cl(-) cotransporterNa+-K+-Cl− cotransporter Gamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorheart failureliver scarringkidney diseasehypertensionedemaInhibitorinhibitorinhibit

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Furosemide sodium
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