2. Metabolic Enzyme/Protease Apoptosis
  3. Oxidative Phosphorylation Mitochondrial Metabolism Apoptosis
  4. IACS-010759 hydrochloride

IACS-010759 hydrochloride  (Synonyms: IACS-10759 hydrochloride)

製品番号: HY-112037A 純度: 99.66%
COA 取扱説明書 Technical Support

IACS-010759 hydrochlorideis an orally active, potent mitochondrial complex I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 hydrochlorideinhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. IACS-010759 hydrochloride has the potential for relapsed/refractory AML and solid tumors research.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 1807523-99-4

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 198 在庫あり
Solution
10 mM * 1 mL in DMSO USD 198 在庫あり
Solid
5 mg $150 在庫あり
10 mg $220 在庫あり
25 mg $450 在庫あり
50 mg $650 在庫あり
100 mg $950 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 26 publication(s) in Google Scholar

Other Forms of IACS-010759 hydrochloride:

IACS-010759 hydrochloride 関連抗体

Top Publications Citing Use of Products

    IACS-010759 hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 9:e07524.  [Abstract]

    IACS-010759 (7.5 mg/kg; p.o. every other day) enhances irradiation efficacy for ESCC xenograft tumors.

    IACS-010759 hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jun 10:e2401396.  [Abstract]

    Cell viability was measured for 22Rv1 and C4-2B cells after treatment with IACS-010759 (0.01-1000 nM) in the presence or absence of Enzalutamide for 5 days.

    IACS-010759 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Jul 14;14(1):4221.  [Abstract]

    Response of HBCx-124 to different doses of IACS-010759 (10-75 mg/kg; 5 days per week) and to Metformin P values were calculated with the Mann-Whitney test (two-tailed).

    IACS-010759 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Jul 14;14(1):4221.  [Abstract]

    Effect of IACS-010759 (0.01 nM-100 μM; 72 h) on in vitro models of ER+ breast cancer sensitive and resistant cells. Relative viability of MCF7 WT/LTED/ PalboR and of T47D WT/LTED derivatives cells.

    IACS-010759 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Jul 14;14(1):4221.  [Abstract]

    MCF7-LTED and PalboR cells were treated with 1 μM IACS for 72 h and ROS levels were measured using CellROX and DCFDA staining.

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    IACS-010759 hydrochlorideis an orally active, potent mitochondrial complex I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 hydrochlorideinhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. IACS-010759 hydrochloride has the potential for relapsed/refractory AML and solid tumors research[1][2].

    IC50 & Target

    OXPHOS[1]
    体外実験

    IACS-010759 hydrochloride (10, 30, 100?nM; for 4 or 5 days) reduces viability and induces apoptosis in primary AML[1].
    ? IACS-010759 hydrochloride (0.001, 0.01, 0.1, 1, 10, 100, 1000 nM; 72 hurs) robustly inhibits both OCR and galactose-dependent H460 cell viability and has nearly identical IC50 values of 1.4?nM[1].
    ? IACS-010759 hydrochlorideis similarly active in mouse (average IC50?=?5.6?nM), rat (IC50?=?12.2?nM), and cynomolgus monkey (IC50?=?8.7?nM) cell lines[1].
    ?

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    IACS-010759 hydrochloride 関連抗体
    体内実験

    IACS-010759 hydrochloride (5, 10, 25?mg/kg/day; oral; for 21 d) results in tumor regression with minimal body weight loss at the 5 or 10?mg/kg dose in mice bearing NB-1 (PGD-null) subcutaneous xenografts. IACS-010759 at the 25?mg/kg dose is not tolerated[1].
    ? IACS-010759 HCl (10?mg/kg; orally; QD (daily) or QD×5 (5 d on/2 d off); for 35 d) increases median survival from 28 d to longer than 60 d, whereas less-frequent dosing schedules (Q2D or Q3D) enhances survival to a lesser extent[1].
    ? IACS-010759 hydrochloride (0.3?mg/kg for iv; 1?mg/kg for oral) has low plasma clearance with a high volume of distribution, resulting in a prolonged terminal half-life (>24?h)[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    599.02

    分子式

    C25H26ClF3N6O4S
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC(N5CCC(S(=O)(C)=O)CC5)=CC=C4)C(C)=N3)=N2)C=C1.Cl
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    DMSO : 60 mg/mL (100.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6694 mL 8.3470 mL 16.6939 mL
    5 mM 0.3339 mL 1.6694 mL 3.3388 mL
    10 mM 0.1669 mL 0.8347 mL 1.6694 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Volume
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

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    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (4.17 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.66%

    COA (248 KB) HNMR (134 KB) LCMS (102 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.6694 mL 8.3470 mL 16.6939 mL 41.7348 mL
    5 mM 0.3339 mL 1.6694 mL 3.3388 mL 8.3470 mL
    10 mM 0.1669 mL 0.8347 mL 1.6694 mL 4.1735 mL
    15 mM 0.1113 mL 0.5565 mL 1.1129 mL 2.7823 mL
    20 mM 0.0835 mL 0.4173 mL 0.8347 mL 2.0867 mL
    25 mM 0.0668 mL 0.3339 mL 0.6678 mL 1.6694 mL
    30 mM 0.0556 mL 0.2782 mL 0.5565 mL 1.3912 mL
    40 mM 0.0417 mL 0.2087 mL 0.4173 mL 1.0434 mL
    50 mM 0.0334 mL 0.1669 mL 0.3339 mL 0.8347 mL
    60 mM 0.0278 mL 0.1391 mL 0.2782 mL 0.6956 mL
    80 mM 0.0209 mL 0.1043 mL 0.2087 mL 0.5217 mL
    100 mM 0.0167 mL 0.0835 mL 0.1669 mL 0.4173 mL
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    IACS-010759 hydrochloride Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    IACS-0107591807523-99-4IACS-10759IACS010759IACS 010759IACS10759IACS 10759Oxidative PhosphorylationMitochondrial MetabolismApoptosisorallymitochondrialcomplexIoxidativephosphorylationOXPHOSAMLH460Inhibitorinhibitorinhibit

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    製品名:
    IACS-010759 hydrochloride
    製品番号:
    HY-112037A
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