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Results for "

L74

" in MedChemExpress (MCE) Product Catalog:

31

Inhibitors & Agonists

2

Natural
Products

3

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10572
    Efavirenz
    15+ Cited Publications

    DMP 266; EFV; L-743726

    		 Reverse Transcriptase HIV Autophagy Endogenous Metabolite Parasite Infection Cancer
    Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .
    Efavirenz
  • HY-17006
    Caspofungin diacetate
    5+ Cited Publications

    MK-0991 diacetate; L-743872 diacetate

    		 Fungal Antibiotic Bacterial Infection Cancer
    Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan .
    Caspofungin diacetate
  • HY-13625
    Ertapenem sodium
    10+ Cited Publications

    L-749345; MK-826

    		 Bacterial Antibiotic Infection Cancer
    Ertapenem sodium (L-749345) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem sodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem sodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract .
    Ertapenem sodium
  • HY-17006A
    Caspofungin
    5+ Cited Publications

    MK-0991; L-743872

    		 Antibiotic Fungal Bacterial Infection Cancer
    Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan .
    Caspofungin
  • HY-101348
    L-741626
    2 Publications Verification

    		 Dopamine Receptor Neurological Disease
    L-741626 is a selective D2 dopamine receptor antagonist, with the Ki values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively .
    L-741626
  • HY-103211
    L748337
    1 Publications Verification

    		 Adrenergic Receptor Cardiovascular Disease Metabolic Disease Cancer
    L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively . L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6 . L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases .
    L748337
  • HY-13625R
    Ertapenem sodium (Standard)

    L-749345 (Standard); MK-826 (Standard)

    		 Reference Standards Bacterial Antibiotic Infection Cancer
    Ertapenem sodium (Standard) is the analytical standard of Ertapenem sodium. This product is intended for research and analytical applications. Ertapenem sodium (L-749345) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem sodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem sodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract[1][2].
    Ertapenem sodium (Standard)
  • HY-14325
    L-745870
    3 Publications Verification

    		 Dopamine Receptor Neurological Disease
    L-745870 is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors .
    L-745870
  • HY-14325B
    L-745870 hydrochloride
    3 Publications Verification

    		 Dopamine Receptor Neurological Disease
    L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors .
    L-745870 hydrochloride
  • HY-118368
    L-742001 hydrochloride

    		Influenza Virus Infection Inflammation/Immunology
    L-742001 hydrochloride is an influenza virus PA endonuclease inhibitor, with an EC90 of 4.3 μM for vRNP activity in HEK293T cells .
    L-742001 hydrochloride
  • HY-118944
    L-748328

    		Adrenergic Receptor Endocrinology
    L-748328 is a potent and selective human β3-adrenergic receptor antagonist. L-748328 has a Ki of 3.7 nM against human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. In addition, L-748328 inhibits the lipolytic response induced by the β3-AR agonist L-742791 in isolated non-human primate adipocytes .
    L-748328
  • HY-116428
    L-744832

    		Farnesyl Transferase Ras TGF-β Receptor Apoptosis Cancer
    L-744832 is a farnesyl transferase inhibitor. L-744832 effectively inhibits the farnesylation of H-Ras and N-Ras, but has little effect on K-Ras treatment. L-744832 not only directly targets the oncogenic pathway by inhibiting Ras farnesylation, but also enhances radiosensitivity by restoring TGF-β signaling through epigenetic reprogramming. L-744832 can induce cell cycle arrest and apoptosis. L-744832 can be used in combination therapy studies for Ras-driven tumors such as pancreatic cancer .
    L-744832
  • HY-17006S
    Caspofungin-d4 diacetate

    MK-0991-d4 diacetate; L-743872-d4 diacetate

    		 Fungal Bacterial Antibiotic Infection
    Caspofungin-d4 (acetate) is the deuterium labeled Caspofungin diacetate . Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan .
    Caspofungin-d4 diacetate
  • HY-119095
    L-741671

    		Neurokinin Receptor Neurological Disease Endocrinology
    L-741671 is a selective and brain-permeable antagonist of neurokininl (hNKI) receptor, with Kis of 64 nM, 0.03 nM and 0.7 nM in rat, human and ferret, respectively .
    L-741671
  • HY-14325R
    L-745870 (Standard)

    		Dopamine Receptor Neurological Disease
    L-745870 (Standard) is the analytical standard of L-745870. This product is intended for research and analytical applications. L-745870 is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors .
    L-745870 (Standard)
  • HY-17006R
    Caspofungin diacetate (Standard)

    MK-0991 diacetate (Standard); L-743872 diacetate (Standard)

    		 Reference Standards Fungal Antibiotic Bacterial Infection Cancer
    Caspofungin (diacetate) (Standard) is the analytical standard of Caspofungin (diacetate). This product is intended for research and analytical applications. Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan .
    Caspofungin diacetate (Standard)
  • HY-10572R
    Efavirenz (Standard)

    DMP 266 (Standard); EFV (Standard); L-743726 (Standard)

    		 Reference Standards Reverse Transcriptase HIV Autophagy Endogenous Metabolite Parasite Infection Cancer
    Efavirenz (Standard) is the analytical standard of Efavirenz. This product is intended for research and analytical applications. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .
    Efavirenz (Standard)
  • HY-10572S1
    Efavirenz-13C6

    DMP 266-13C6; EFV-13C6; L-743726-13C6

    		 Isotope-Labeled Compounds Reverse Transcriptase HIV Autophagy Endogenous Metabolite Infection Cancer
    Efavirenz- 13C6 is the 13C-labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .
    Efavirenz-13C6
  • HY-116970
    L-749372

    		Adrenergic Receptor Others
    L-749372 is a selective partial agonist beta 3 adrenergic receptor (EC50= 3.6 nM) .
    L-749372
  • HY-117527
    L742791

    		Adrenergic Receptor Metabolic Disease
    L742791 is a β3-AR agonist. L742791 elicits lipolytic response in isolated nonhuman primate adipocytes .
    L742791
  • HY-125692
    L-740093

    		Cholecystokinin Receptor Neurological Disease
    L-740093 is a potent cholecystokinin-B receptor antagonist. L-740093 has excellent central nervous system (CNS) penetration .
    L-740093
  • HY-14325A
    L-745870 trihydrochloride

    		Dopamine Receptor Neurological Disease
    L-745870 trihydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 trihydrochloride shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors .
    L-745870 trihydrochloride
  • HY-117644
    L-749329

    (Rac)-L-754142

    		 Endothelin Receptor Cardiovascular Disease
    L-749329 ((Rac)-L-754142) is an ETA and ETB receptor antagonist, with Kis of 0.062 nM and 2.25 nM for ETA and ETB respectively. L-749329 inhibits ET-1-stimulated signaling .
    L-749329
  • HY-14325BR
    L-745870 hydrochloride (Standard)

    		Dopamine Receptor Neurological Disease
    L-745870 (hydrochloride) (Standard) is the analytical standard of L-745870 (hydrochloride). This product is intended for research and analytical applications. L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors .
    L-745870 hydrochloride (Standard)
  • HY-101349
    L 741742

    		Dopamine Receptor Apoptosis Autophagy PDGFR ERK mTOR Neurological Disease Cancer
    L 741742 is a highly selective and brain-penetrant D4 dopamine receptor antagonist, with Ki values of 3.5 nM, 770 nM and >1700 nM for human D4, D3 and D2 receptors, respectively. L 741742 suppresses PDGFRβ, ERK1/2, and mTOR signaling pathways, and impairs autophagic flux while disrupting lysosomal function.L 741742 induces G0/G1 cell-cycle arrest and apoptosis, promotes neuronal differentiation of normal human neural stem cells, selectively inhibits growth and clonogenic potential of glioblastoma neural stem cells and primary glioblastoma tumor cells, exerts synergistic effects with Temozolomide (TMZ) (HY-17364) against glioblastoma neural stem cells in vitro, and inhibits glioblastoma neural stem cell xenograft growth in immunocompromised mice. L 741742 can be used for the research of schizophrenia and glioblastoma .
    L 741742
  • HY-117952
    L 743310

    		Neurokinin Receptor Neurological Disease
    L 743310 is a non-peptide, selective antagonist of the human neurokinin hNK1 receptor, with high affinity for primate and cloned human hNK1 receptors and lower affinity for rodent NK1 receptors. L 743310 inhibits resiniferatoxin-induced plasma protein extravasation in guinea pig esophagus. L 743310 has a dose-dependent inhibitory effect on cisplatin-induced emesis .
    L 743310
  • HY-116610
    L 748780

    		COX Inflammation/Immunology
    L 748780 (compound 2) is a selectivity COX-2 inhibitor with the IC50 values of 0.5 μM and ＞ 100 μM for COX-2 and COX-1, respectively .
    L 748780
  • HY-19217
    Thioflosulide

    L-745337

    		 COX Inflammation/Immunology
    Thioflosulide (L-745337) is a selective cyclooxygenase-2 (COX2) inhibitor, with an IC50 of 2.3 nM, and shows anti-inflammatory activity.
    Thioflosulide
  • HY-101349A
    L 741742 hydrochloride

    		Dopamine Receptor Apoptosis Autophagy PDGFR ERK mTOR Neurological Disease Cancer
    L 741742 hydrochloride is a highly selective and brain-penetrant D4 dopamine receptor antagonist, with Ki values of 3.5 nM, 770 nM and >1700 nM for human D4, D3 and D2 receptors, respectively. L 741742 hydrochloride suppresses PDGFRβ, ERK1/2, and mTOR signaling pathways, and impairs autophagic flux while disrupting lysosomal function.L 741742 hydrochloride induces G0/G1 cell-cycle arrest and apoptosis, promotes neuronal differentiation of normal human neural stem cells, selectively inhibits growth and clonogenic potential of glioblastoma neural stem cells and primary glioblastoma tumor cells, exerts synergistic effects with Temozolomide (TMZ) (HY-17364) against glioblastoma neural stem cells in vitro, and inhibits glioblastoma neural stem cell xenograft growth in immunocompromised mice. L 741742 hydrochloride can be used for the research of schizophrenia and glioblastoma .
    L 741742 hydrochloride
  • HY-17006AS
    Caspofungin-d4

    MK-0991-d4; L-743872-d4

    		 Isotope-Labeled Compounds Fungal Antibiotic Bacterial Infection
    Caspofungin-d4 (MK-0991-d4; L-743872-d4) is a deuterium labeled Caspofungin (HY-17006A). Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan .
    Caspofungin-d4
  • HY-101348R
    L-741626 (Standard)

    		Reference Standards Dopamine Receptor Neurological Disease
    L-741626 (Standard) is the analytical standard of L-741626. This product is intended for research and analytical applications. L-741626 is a selective D2 dopamine receptor antagonist, with the Ki values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively .
    L-741626 (Standard)

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