1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Ertapenem sodium

Ertapenem sodium (Synonyms: L-749345; MK-826)

Cat. No.: HY-13625 Purity: 99.09%
Handling Instructions

Ertapenem sodium (L-749345; MK-826) is a long-acting, β-lactam antibiotic of carbapenem class, with a broad antibacterial spectrum. Ertapenem is active against both Gram-positive and Gram-negative bacteria, including Enterobacteriaceae, Streptococcus pneumoniae and most species of anaerobic bacteria.

For research use only. We do not sell to patients.

Ertapenem sodium Chemical Structure

Ertapenem sodium Chemical Structure

CAS No. : 153773-82-1

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Based on 2 publication(s) in Google Scholar

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Description

Ertapenem sodium (L-749345; MK-826) is a long-acting, β-lactam antibiotic of carbapenem class, with a broad antibacterial spectrum. Ertapenem is active against both Gram-positive and Gram-negative bacteria, including Enterobacteriaceae, Streptococcus pneumoniae and most species of anaerobic bacteria[1][2].

In Vitro

Ertapenem sodium inhibits Streptococcus pneumoniae with MIC50s values < 1mg/L[2].
Ertapenem sodium exhibits a bactericidal mode of action as shown by time-killing curves and exhibits a short postantibiotic effect (PAE) of 1.4-2.6 h against the Gram-positive strains but no PAE against Gram-negative strains[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ertapenem sodium (50 mg/kg; s.c.; q6h; for 24 hours) shows substantial bactericidal activity against S. pneumoniae in the murine thigh infection model[3].
Ertapenem sodium produces an AUC0-24 of 586 mg • h/liter, a Cmax of 140 mg/liter at a 50 mg/kg q6h dosing regimen[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Specific-pathogen-free female ICR mice (~25 g), thigh infection model[3]
Dosage: 50 mg/kg
Administration: Subcutaneous injection, q6h, for 24 hours
Result: Showed substantial bactericidal activities.
Animal Model: Specific-pathogen-free female ICR mice (~25 g), thigh infection model[3]
Dosage: 20 mg/kg, 50 mg/kg, 100 mg/kg (Pharmacokinetic Analysis)
Administration: Subcutaneous injection
Result: Produced an AUC0-24 of 586 mg • h/liter, a Cmax of 140 mg/liter at 50 mg/kg q6h dosing regimen.
Clinical Trial
Molecular Weight

497.50

Formula

C₂₂H₂₄N₃NaO₇S

CAS No.

153773-82-1

SMILES

O=C([[email protected]]1NC[[email protected]@H](SC2=C(C(O)=O)N3[[email protected]]([[email protected]]([[email protected]@H](C)O)([H])C3=O)([H])[[email protected]]2C)C1)NC4=CC=CC(C(O[Na])=O)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (100.50 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0101 mL 10.0503 mL 20.1005 mL
5 mM 0.4020 mL 2.0101 mL 4.0201 mL
10 mM 0.2010 mL 1.0050 mL 2.0101 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

ErtapenemL-749345 MK-826L749345L 749345MK826MK 826MK-826BacterialAntibioticβ-lactambeta- lactamantibacterialGram-positive Gram-negativeinfectionInhibitorinhibitorinhibit

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Ertapenem sodium
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HY-13625
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