2. Apoptosis
  3. Bcl-2 Family
  4. MIK665

MIK665 (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 (MCL1) inhibitor. MIK665 has an IC50 of 1.81 nM for MCL1.

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CAS 番号 : 1799631-75-6

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 674 在庫あり
Solution
10 mM * 1 mL in DMSO USD 674 在庫あり
Solid
1 mg $166 在庫あり
5 mg $350 在庫あり
10 mg $550 在庫あり
25 mg $1020 在庫あり
50 mg $1650 在庫あり
100 mg $2300 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 17 publication(s) in Google Scholar

Other Forms of MIK665:

MIK665 関連抗体

Top Publications Citing Use of Products

    MIK665 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 21;16(1):7688.  [Abstract]

    MIK665 (S-64315) (10-50 nM; 24 h) effectively and rapidly induced cell death of CDS-ZH003.

    MIK665 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 21;16(1):7688.  [Abstract]

    MIK665 (S-64315) (20 mg/kg; i.v.; twice a week for 3 weeks) regressed tumors and significantly prolonged the survival of NSG mice.

    MIK665 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2024 Apr 4;84(7):1338-1353.e8.  [Abstract]

    MIK665 (S-64315) (500 nM) stabilized MCL-1 of 293T cellsbut repressed the ability of human MCL-1 to co-precipitate with ACSL1 and BIM.

    MIK665 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2024 Apr 4;84(7):1338-1353.e8.  [Abstract]

    MIK665 (S-64315) (500 nM) significantly repressed the utilization of oleate-containing lipid droplets in hMCL-1 MEFs.

    MIK665 purchased from MedChemExpress. Usage Cited in: Mol Cell. 2024 Apr 4;84(7):1338-1353.e8.  [Abstract]

    MCL-1 inhibitor MIK665 (S-64315) (50 mg/kg; i.v.; once daily for 5 d) significantly repressed palmitate oxidation in heart mitochondria from C57BL/6J mice.

    MIK665 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Jun 8;11(6):443.  [Abstract]

    S64315+A-1331852 and S64315+ABT-263 significantly reduces cell viability compared with DMSO or with single drug treated conditions in all melanoma cell lines at sub-micromolar doses.

    Bcl-2 Family アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

    • 生物活性

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    製品説明

    MIK665 (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 (MCL1) inhibitor[1]. MIK665 has an IC50 of 1.81 nM for MCL1[2].

    IC50 & Target[1]

    Mcl-1

    1.81 nM (IC50)

    Cellular Effect
    Cell Line Type Value Description References
    NCI-H929 IC50
    1.7 1
    Compound: 9m; S64315; MIK665
    Antiproliferative activity against human NCI-H929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human NCI-H929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 33146521]
    NCI-H929 IC50
    1.7 1
    Compound: 9m; S64315; MIK665
    Antiproliferative activity against human NCI-H929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human NCI-H929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 33146521]
    体外実験

    MIK665 (S-64315) has similar synergistic effects as S63845, when combined with ABT-199. The combination S64315 (0.156-10 μM) and ABT-199 (625 nM) has similar efficacy in reducing the cell viability of representative melanoma lines (MB2141, MB3616, MB3961, MB4667, A375, and 1205Lu cells)[1].
    MIK665 is extracted from patent WO2016207225A1, compound Preparation 13, and inhibits H929 cell with an IC50 of 250 nM[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    MIK665 関連抗体
    臨床実験
    分子量

    875.41

    分子式

    C47H44ClFN6O6S
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC([C@@H](CC(C=CC=C1)=C1OCC2=CC=NC(C3=CC=CC=C3OC)=N2)OC4=C5[C@]([C@]6=C(C)C(Cl)=C(OCCN7CCN(C)CC7)C=C6)=C(C8=CC=C(F)C=C8)SC5=NC=N4)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : ≥ 125 mg/mL (142.79 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1423 mL 5.7116 mL 11.4232 mL
    5 mM 0.2285 mL 1.1423 mL 2.2846 mL
    10 mM 0.1142 mL 0.5712 mL 1.1423 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

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    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (2.38 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (2.38 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
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    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.11%

    COA (254 KB) HNMR (152 KB) LCMS (96 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.1423 mL 5.7116 mL 11.4232 mL 28.5580 mL
    5 mM 0.2285 mL 1.1423 mL 2.2846 mL 5.7116 mL
    10 mM 0.1142 mL 0.5712 mL 1.1423 mL 2.8558 mL
    15 mM 0.0762 mL 0.3808 mL 0.7615 mL 1.9039 mL
    20 mM 0.0571 mL 0.2856 mL 0.5712 mL 1.4279 mL
    25 mM 0.0457 mL 0.2285 mL 0.4569 mL 1.1423 mL
    30 mM 0.0381 mL 0.1904 mL 0.3808 mL 0.9519 mL
    40 mM 0.0286 mL 0.1428 mL 0.2856 mL 0.7140 mL
    50 mM 0.0228 mL 0.1142 mL 0.2285 mL 0.5712 mL
    60 mM 0.0190 mL 0.0952 mL 0.1904 mL 0.4760 mL
    80 mM 0.0143 mL 0.0714 mL 0.1428 mL 0.3570 mL
    100 mM 0.0114 mL 0.0571 mL 0.1142 mL 0.2856 mL
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    MIK665 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    MIK6651799631-75-6S-64315MIK 665MIK-665S64315S 64315Bcl-2 FamilyBH3mimeticmyeloidcellsleukemiadeathmelanomaInhibitorinhibitorinhibit

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    製品名:
    MIK665
    製品番号:
    HY-112218
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