2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Menadione bisulfite sodium

Menadione bisulfite (sodium)  (Synonyms: Menadione sodium bisulfite; Vitamin K3 sodium bisulfite；メナジオンナトリウム亜硫酸；メナジオンスルホン酸ナトリウム)

製品番号: HY-B1897A 純度: 99.93%
COA 取扱説明書 Technical Support

Menadione bisulfite (sodium) is used as an agent to induce acute oxidative stress, and to function as a plant-defense activator against several pathogens.

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Menadione bisulfite sodium

Menadione bisulfite (sodium) 構造式

CAS 番号 : 130-37-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Solid
500 mg $30 在庫あり
1 g $45 在庫あり
5 g $72 在庫あり
10 g $90 在庫あり
25 g $125 在庫あり
50 g $150 在庫あり
100 g $180 在庫あり
> 100 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Menadione bisulfite (sodium) 関連抗体

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製品説明

Menadione bisulfite (sodium) is used as an agent to induce acute oxidative stress, and to function as a plant-defense activator against several pathogens.

体外実験

Menadione sodium bisulfite (500 μM) treatment and the concomitant ROS increase have an important impact on the photosynthetic activity of the cells. Global and specific antioxidant defences decrease with Menadione sodium bisulfite (500 μM) treatment[1]. Menadione sodium bisulfite and PABA activate similar defense responses (PR, ROS, and HR). Menadione sodium bisulfite enhances resistance, both locally and systemically, to phoma stem canker disease caused by Leptosphaeria maculans. Menadione sodium bisulfite treatment induces resistance against downy mildew in pearl millet. Menadione sodium bisulfite acts through priming of specific sets of the plant innate-defense repertoire. Menadione sodium bisulfite treatment up-regulates the expression of a gene encoding a GRX480 protein, a member of the glutaredoxin family that regulates protein redox state[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Menadione bisulfite (sodium) 関連抗体
分子量

276.25

分子式

C11H9NaO5S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=S(C(CC(C1=C2C=CC=C1)=O)(C)C2=O)(O[Na])=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : ≥ 100 mg/mL (362.00 mM)

DMSO : 100 mg/mL (362.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6200 mL 18.0999 mL 36.1997 mL
5 mM 0.7240 mL 3.6200 mL 7.2400 mL
10 mM 0.3620 mL 1.8100 mL 3.6200 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (9.05 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (9.05 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 120 mg/mL (434.40 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.93%

COA (254 KB) HNMR (260 KB) RP-HPLC (246 KB) MS (180 KB)

取扱説明書 (2659 KB)
参考文献
キナーゼ実験
[1]

Briefly, cells are lysed by sonication (6 cycles of 10 s separated by 30 s, on ice) in a buffer containing 25 mM Hepes at pH 7.5, 5 mM MgCl2, 5 mM DTT, 2 mM PMSF, 5 mM EDTA, 400 mM sorbitol and 10 μg/mL Protease Inhibitor cocktail. A quantity of 40 μg Symbiodinium protein extract is incubated in the reaction buffer. The mixture consists of 50 μM Ac-DEVD-AFC, 100 mM Hepes at pH 7.5, 10% (v/v) sucrose, 0.1% (v/v) CHAPS, 10 mM DTT and 10 mM PMSF. Samples are then incubated in black 96-well microplates and the fluorescence emitted is measured every 3 min for 90 min at 505 nm, with a 400 nm excitation wavelength provided by a FLX-Xenius spectrofluorometer. Caspase-like activities are then expressed in pmol of AFC cleavage per minute and illustrated as percentage of the controls.

MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.6200 mL 18.0999 mL 36.1998 mL 90.4994 mL
5 mM 0.7240 mL 3.6200 mL 7.2400 mL 18.0999 mL
10 mM 0.3620 mL 1.8100 mL 3.6200 mL 9.0499 mL
15 mM 0.2413 mL 1.2067 mL 2.4133 mL 6.0333 mL
20 mM 0.1810 mL 0.9050 mL 1.8100 mL 4.5250 mL
25 mM 0.1448 mL 0.7240 mL 1.4480 mL 3.6200 mL
30 mM 0.1207 mL 0.6033 mL 1.2067 mL 3.0166 mL
40 mM 0.0905 mL 0.4525 mL 0.9050 mL 2.2625 mL
50 mM 0.0724 mL 0.3620 mL 0.7240 mL 1.8100 mL
60 mM 0.0603 mL 0.3017 mL 0.6033 mL 1.5083 mL
80 mM 0.0452 mL 0.2262 mL 0.4525 mL 1.1312 mL
100 mM 0.0362 mL 0.1810 mL 0.3620 mL 0.9050 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Menadione bisulfite sodium Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Menadione bisulfite130-37-0Menadione sodium bisulfite Vitamin K3 sodium bisulfiteEndogenous MetaboliteInhibitorinhibitorinhibit

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