2. Neuronal Signaling Apoptosis
  3. Amyloid-β Apoptosis
  4. Notoginsenoside R1

Notoginsenoside R1  (Synonyms: ノトギンセノシドR1; Sanchinoside R1; Sanqi glucoside R1)

製品番号: HY-N0615 純度: 99.93%
COA 取扱説明書 Technical Support

Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells.

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CAS 番号 : 80418-24-2

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 62 在庫あり
Solution
10 mM * 1 mL in DMSO USD 62 在庫あり
Solid
5 mg $30 在庫あり
10 mg $47 在庫あり
25 mg $84 在庫あり
50 mg $127 在庫あり
100 mg $190 在庫あり
250 mg $342 在庫あり
500 mg $514 在庫あり
1 g $668 在庫あり
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10 g   お問い合わせ  

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カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of Notoginsenoside R1:

Notoginsenoside R1 関連抗体

Top Publications Citing Use of Products
IF
WB
Cell Proliferation/Viability Assay
Bio/Physico-chemical Assay
In Vivo Efficacy Study

    Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Res Sq. 2024 Jul 12.

    Notoginsenoside R1 (NGR1, 2.5-20 μM; 24 h) treatment did not significantly affect the cell viability of PPARγ/PPRE-transfected HT22 cells.

    Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Res Sq. 2024 Jul 12.

    Notoginsenoside R1 (NGR1, 2.5-20 μM; 24 h) treatment notably increased the luciferase activity in the PPARγ/PPRE-transfected HT22 cells.

    Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Res Sq. 2024 Jul 12.

    Notoginsenoside R1 (NGR1, 10 µM; 24 h) treatment promoted GLUT4 membrane translocation in primary mouse hippocampal neurons. Scale bar = 20 μm.

    Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Res Sq. 2024 Jul 12.

    Notoginsenoside R1 (NGR1, 10-80 mg/kg; i.g.; 16 weeks) treatment dramatically decreased the levels of fasting blood glucose in APP/PS1xdb/db mice in a dose-dependent manner.

    Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Front Cell Neurosci. 2020 Sep 4;14:280.  [Abstract]

    Effect of Notoginsenoside R1 (R1; 5 μM) on the expression, location, and cleavage status of sodium channel proteins after Aβ1-42 treatment.

    Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Front Cell Neurosci. 2020 Sep 4;14:280.  [Abstract]

    Effect of Notoginsenoside R1 (R1, 5 μM) on Aβ1-42 (5 μM)–induced neuron viability determined using MTT assay. Cell viability of cultured neurons treated with different groups at 0 h, 24 h, 48 h, 72 h, and 96 h.

    Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Front Cell Neurosci. 2020 Sep 4;14:280.  [Abstract]

    Notoginsenoside R1 (R1, 5 μM) was responsible for reducing abnormal excitability in Aβ1-42–induced neurons.

    Notoginsenoside R1 purchased from MedChemExpress. Usage Cited in: Front Cell Neurosci. 2020 Sep 4;14:280.  [Abstract]

    Notoginsenoside R1 (R1, 5 mg/kg; i.g.; once daily for 6 months) partially improved the Marris Water Maze (MWM) test behavior in APP/PS1 mice.

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    • 純度とドキュメンテーション

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    製品説明

    Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells[1][2][3].

    体外実験

    Notoginsenoside R1 (2.5-80 μM; 24 h) inhibits the hypoxia-reoxygenation (H/R)-induced cell death, intracellular ROS accumulation, and mitochondrial membrane depolarization in H9c2 cardiomyocytes[1].
    ? Notoginsenoside R1 (5-20 μM; 24 h) inhibits the H/R-induced H9c2 cardiomyocytes apoptosis in a concentration-dependent manner[1].
    ? Notoginsenoside R1 (1-100 μM; 24 h) dose-dependently protects PC12 cells and primary neurons from Aβ-induced cell death and apoptosis[2].
    ? Notoginsenoside R1 (10 μM; 24 h) inhibits Aβ25-35-induced ROS production, mitochondrial damage and MAPK activation in PC12 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Notoginsenoside R1 関連抗体
    体内実験

    Notoginsenoside R1 (5 mg/kg/h; infused via the right jugular vein) increases red blood cell velocity, reduces the number of adherent leukocytes and inhibits mast cell degranulation and cytokine elevation in rats[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Sprague-Dawley (SD) rats (200-250 g)[3]
    Dosage: 5 mg/kg/h
    Administration: Infused 20 min before LPS infusion via the right jugular vein
    Result: Ameliorated the LPS-induced reduction in the mesenteric venular shear rate to some extent.
    Attenuated the LPS-induced adhesion of leukocytes to the venular wall.
    Inhibited mast cell degranulation and cytokine elevation.
    分子量

    933.13

    分子式

    C47H80O18
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O)C)(C[C@H](O[C@@](O[C@H](CO)[C@@H](O)[C@@H]4O)([H])[C@@H]4O[C@@](OC[C@@H](O)[C@@H]5O)([H])[C@@H]5O)[C@@]2([H])C3(C)C)[C@]6([C@@]1([H])[C@]([C@@](CC/C=C(C)/C)(C)O[C@@H]([C@@H]([C@@H](O)[C@@H]7O)O)O[C@@H]7CO)([H])CC6)C
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (107.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.0717 mL 5.3583 mL 10.7166 mL
    5 mM 0.2143 mL 1.0717 mL 2.1433 mL
    10 mM 0.1072 mL 0.5358 mL 1.0717 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

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    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (2.68 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (2.68 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
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    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.93%

    COA (266 KB) HNMR (340 KB) RP-HPLC (206 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.0717 mL 5.3583 mL 10.7166 mL 26.7916 mL
    5 mM 0.2143 mL 1.0717 mL 2.1433 mL 5.3583 mL
    10 mM 0.1072 mL 0.5358 mL 1.0717 mL 2.6792 mL
    15 mM 0.0714 mL 0.3572 mL 0.7144 mL 1.7861 mL
    20 mM 0.0536 mL 0.2679 mL 0.5358 mL 1.3396 mL
    25 mM 0.0429 mL 0.2143 mL 0.4287 mL 1.0717 mL
    30 mM 0.0357 mL 0.1786 mL 0.3572 mL 0.8931 mL
    40 mM 0.0268 mL 0.1340 mL 0.2679 mL 0.6698 mL
    50 mM 0.0214 mL 0.1072 mL 0.2143 mL 0.5358 mL
    60 mM 0.0179 mL 0.0893 mL 0.1786 mL 0.4465 mL
    80 mM 0.0134 mL 0.0670 mL 0.1340 mL 0.3349 mL
    100 mM 0.0107 mL 0.0536 mL 0.1072 mL 0.2679 mL
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    Notoginsenoside R1 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Notoginsenoside R180418-24-2Sanchinoside R1 Sanqi glucoside R1Notoginsenoside R 1Notoginsenoside R-1Sanchinoside R 1Sanchinoside R-1Sanqi glucoside R1Sanqi glucoside R 1Sanqi glucoside R-1Amyloid-βApoptosisβ-amyloid peptideAβAbetasaponinanti-oxidationanti-inflammatoryanti-angiogenicanti-apoptosis,cardioprotectionI/RneuroprotectionInhibitorinhibitorinhibit

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    製品名:
    Notoginsenoside R1
    製品番号:
    HY-N0615
    数量:
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