2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. Procarbazine Hydrochloride

Procarbazine (Hydrochloride)  (Synonyms: プロカルバジン 塩酸塩)

製品番号: HY-13733 純度: 99.66%
COA 取扱説明書 Technical Support

Procarbazine Hydrochloride is an orally active alkylating agent, with anticancer activity. Procarbazine Hydrochloride can be used in Hodgkin's disease research.

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Procarbazine Hydrochloride

Procarbazine (Hydrochloride) 構造式

CAS 番号 : 366-70-1

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
100 mg $50 在庫あり
500 mg $156 在庫あり
1 g   お問い合わせ  
5 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 4 publication(s) in Google Scholar

Other Forms of Procarbazine Hydrochloride:

Procarbazine (Hydrochloride) 関連抗体

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製品説明

Procarbazine Hydrochloride is an orally active alkylating agent, with anticancer activity. Procarbazine Hydrochloride can be used in Hodgkin's disease research[1][2].

体外実験

Procarbazine Hydrochloride (5 and 20 nM; 1 h) treatment shows cell survival at various concentrarions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Procarbazine (Hydrochloride) 関連抗体

Cell Viability Assay[1]

Cell Line: L1210 cells
Concentration: 5 and 20 nM
Incubation Time: 1 hour
Result: Showed 99.3% and 99.9% survival of cells at 5 mM and 20 mM, respectively.
体内実験

Procarbazine (Intraperitoneal injection; 50 and 150 mg/kg; once daily; 5 d) induces micronuclei in hematopoietic cells, but not increases the lacZ mutant frequency (MF) in bone marrow[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male muta mouse (7–8 weeks old)[2]
Dosage: 50 and 150 mg/kg
Administration: Intraperitoneal injection; 50 and 150 mg/kg; once daily; 5 days
Result: Increased the MN frequency appreciably, and observed micronucleus induction in the peripheral blood at 50 mg/kg.
分子量

257.76

分子式

C12H20ClN3O
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC(C)C)C1=CC=C(CNNC)C=C1.Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (387.96 mM; Need ultrasonic)

DMSO : 16.67 mg/mL (64.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8796 mL 19.3979 mL 38.7958 mL
5 mM 0.7759 mL 3.8796 mL 7.7592 mL
10 mM 0.3880 mL 1.9398 mL 3.8796 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (8.07 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1.67 mg/mL (6.48 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (387.96 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.66%

COA (244 KB) HNMR (341 KB) RP-HPLC (252 KB) LCMS (94 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.8796 mL 19.3979 mL 38.7958 mL 96.9894 mL
5 mM 0.7759 mL 3.8796 mL 7.7592 mL 19.3979 mL
10 mM 0.3880 mL 1.9398 mL 3.8796 mL 9.6989 mL
15 mM 0.2586 mL 1.2932 mL 2.5864 mL 6.4660 mL
20 mM 0.1940 mL 0.9699 mL 1.9398 mL 4.8495 mL
25 mM 0.1552 mL 0.7759 mL 1.5518 mL 3.8796 mL
30 mM 0.1293 mL 0.6466 mL 1.2932 mL 3.2330 mL
40 mM 0.0970 mL 0.4849 mL 0.9699 mL 2.4247 mL
50 mM 0.0776 mL 0.3880 mL 0.7759 mL 1.9398 mL
60 mM 0.0647 mL 0.3233 mL 0.6466 mL 1.6165 mL
H2O 80 mM 0.0485 mL 0.2425 mL 0.4849 mL 1.2124 mL
100 mM 0.0388 mL 0.1940 mL 0.3880 mL 0.9699 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Procarbazine Hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Procarbazine366-70-1DNA Alkylator/Crosslinkeranticancer activityHodgkin's diseaseL1210Inhibitorinhibitorinhibit

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製品名:
Procarbazine Hydrochloride
製品番号:
HY-13733
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