2. Infection

Infection

Infection

Related Products

PDF 70.44 MB

Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N7897
    Myrrhone 183551-83-9 99.89%
    Myrrhone is a terpenoid compound with antiplasmodial effects.
    Myrrhone
  • HY-N8105
    Protoneogracillin 191334-50-6 99.96%
    Protoneogracillin, a furostanol glycoside, shows anti-fungal activity against the plant pathogenic fungus P.oryzae (MMDC=94.0 μM) and cytotoxic activity on K562 cancer cells (IC50=6.6 μM).
    Protoneogracillin
  • HY-N8411
    Aromadendrene 489-39-4
    Aromadendrene can be isolated from Eucalyptus globulus. Aromadendrene has antimicrobial activity.
    Aromadendrene
  • HY-N8599
    Cichoriin 531-58-8 99.9%
    Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, α-glucosidase, pancreatic lipase and DPP-IV, with IC50 values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y14R (IC50 = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2.
    Cichoriin
  • HY-P0263
    Dermaseptin 136212-91-4 99.72%
    Dermaseptin, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration.
    Dermaseptin
  • HY-P0310
    SV40 large T antigen NLS 163815-24-5 99.34%
    SV40 large T antigen NLS is from Large T antigen residue 47 to 55, enables protein import into cell nucleus.
    SV40 large T antigen NLS
  • HY-P0311
    LAH4 184776-51-0 98.18%
    LAH4, an alpha-helix of the designed amphipathic peptide antibiotic, exhibits potent antimicrobial, nucleic acid transfection and cell penetration activities. LAH4 possesses high plasmid DNA delivery capacities. LAH4 has a strong affinity for anionic lipids found in the outer membrane of bacterial membranes.
    LAH4
  • HY-P1258
    PSI 158442-41-2
    PSI (Proteasome Inhibitor 1) is a potent proteasome inhibitor. PSI inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI has the potential for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas.
    PSI
  • HY-P1749
    Influenza HA (307-319) 528526-85-4 98.55%
    Influenza HA (307-319) is 13 amino acids 307 to 319 fragment of Influenza HA. Influenza HA is a glycoprotein found on the surface of influenza viruses.
    Influenza HA (307-319)
  • HY-P2460
    SMAP-29 172485-26-6 99.18%
    SMAP‑29 is a cathelicidin antimicrobial peptide with LPS‑binding and anti‑inflammatory properties. SMAP‑29 exerts broad‑spectrum antimicrobial activity against bacteria, fungi and multidrug‑resistant isolates. SMAP‑29 kills pathogens by permeabilizing bacterial membranes, inducing depolarization and cell lysis, and also inhibits inflammatory cytokines while reducing lethality in septic shock and pneumonia models. SMAP-29 can be used for research on bacterial infections, drug-resistant infections, septic shock.
    SMAP-29
  • HY-P4388
    Z-Arg-Leu-Arg-Gly-Gly-AMC 167698-69-3 99.93%
    Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PLpro.
    Z-Arg-Leu-Arg-Gly-Gly-AMC
  • HY-P5581
    Alloferon 1 347884-61-1 99.86%
    Alloferon 1 is an antiviral and antitumoral peptide. Alloferon 1 stimulates natural cytotoxicity of human peripheral blood lymphocytes. Alloferon 1 also induces IFN synthesis, and enhances antiviral and antitumor resistance in mice. Alloferon 1 also shows anti-inflammatory activity in λ-carrageenan-induced paw edema model. Alloferon 1 can be isolated from the blood of the blow fly Calliphora vicina (Diptera).
    Alloferon 1
  • HY-Y0492
    2-Cyanothioacetamide 7357-70-2 98%
    2-Cyanothioacetamide is an antimicrobial agent with activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. 2-Cyanothioacetamide inhibits essential microbial enzymes and disrupts microbial cell membrane integrity.2-Cyanothioacetamide can be used for the research of bacterial infections and fungal infections.
    2-Cyanothioacetamide
  • HY-Y1913
    Potassium tetraborate tetrahydrate, 99.5% 12045-78-2 ≥99.0%
    Potassium tetraborate tetrahydrate, 99.5% has antibacterial activity against Pectobacterium carotovorum. Potassium tetraborate tetrahydrate, 99.5% can be used as a biological material or organic compound for life science related research.
    Potassium tetraborate tetrahydrate, 99.5%
  • HY-100028
    AT-130 211364-06-6 98.39%
    AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor. AT-130 inhibits the viral DNA synthesis with an EC50 of 0.13 μM. AT-130 inhibits both wt and mutant HBVs. AT-130 has anti-HBV activity in hepatoma cells.
    AT-130
  • HY-100555
    CH5138303 959763-06-5 ≥99.0%
    CH5138303 is a potent and orally active Hsp90 inhibitor. CH5138303 shows high binding affinity for N-terminal Hsp90α, with Kd of 0.52 nM. CH5138303 shows potent anti-proliferative activity against human cancer cell lines (HCT116 and NCI-N87), with IC50 values of 0.098 and 0.066 μM, respectively. CH5138303 shows high oral bioavailability in mice (F=44.0%). CH5138303 shows potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model.
    CH5138303
  • HY-100662
    Didesethyl chloroquine 4298-14-0 99.91%
    Didesethyl chloroquine (Bisdesethylchloroquine) is the major metabolite of the antimalarial agent Chloroquine (HY-17589A). Didesethyl chloroquine is a potent myocardial inhibitor. Didesethyl chloroquine reduces calcium binding and accumulation in cardiac mitochondria, induces mitochondrial swelling, rupture and membrane conformational changes. Didesethyl chloroquine inhibits the growth of Plasmodium falciparum strains. Didesethyl chloroquine can be used in research related to malaria, chikungunya virus infection, and cardiovascular and cerebrovascular diseases.
    Didesethyl chloroquine
  • HY-100943
    Cinanserin hydrochloride 54-84-2 99.48%
    Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro.
    Cinanserin hydrochloride
  • HY-100967
    SKF 91488 dihydrochloride 68941-21-9 98.62%
    SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a Ki value of 0.9 μM. SKF 91488 dihydrochloride can block histamine metabolism and increase histamine concentrations. SKF 91488 dihydrochloride can increase blood pressure and enhance bronchoconstriction. SKF 91488 can be used for the researches of infection, inflammation and cardiovascular disease, such as Mycoplasma pneumonia and hemorrhagic hypotension.
    SKF 91488 dihydrochloride
  • HY-103165
    PSB-0788 1027513-54-7 99.68%
    PSB-0788 is a new selective high-affinity A2B antagonist with IC50 value of 3.64 nM and Ki value of 0.393 nM, respeactively. PSB-0788 can be used for the research for chronic inflammatory lung diseases.
    PSB-0788
Cat. No. Product Name / Synonyms Application Reactivity