1. Cell Cycle/DNA Damage
    Anti-infection
  2. DNA/RNA Synthesis
    HBV
  3. AT-130

AT-130 

Cat. No.: HY-100028
Handling Instructions

AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor. AT-130 inhibits the viral DNA synthesis with an IC50 of 0.13 uM. AT-130 inhibits both wt and mutant HBVs. AT-130 has anti-HBV activity in hepatoma cells.

For research use only. We do not sell to patients.

AT-130 Chemical Structure

AT-130 Chemical Structure

CAS No. : 211364-06-6

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50 mg USD 1350 In-stock
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100 mg USD 1950 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor. AT-130 inhibits the viral DNA synthesis with an IC50 of 0.13 uM. AT-130 inhibits both wt and mutant HBVs. AT-130 has anti-HBV activity in hepatoma cells[1][2][3].

In Vitro

AT-130 inhibits Wt HBV (IC50=2.4 μM), rtL180M HBV (IC50=9.8 μM), rtM204I HBV (IC50=35.6 μM)[1].
AT-130 (0.1, 1, 5, 10, 100 uM; for 7 days) causes dose-dependent inhibition of wt HBV replication in HepG2 cells transduced with HBV baculovirus. AT-130 at a concentration of 2.5 uM, reduces encapsidated HBV DNA by 50% (IC50) and at 18.5 uM by 90% (IC90)[1].
AT-130 has no toxic to either HepG2 or Huh-7 cells at concentrations of up to 250 μM[1].
AT-130 (0.005, 0.05, 0.5, 5, 50 uM) does not inhibit HBV DNA synthesis by blocking the HBV endogenous DNA polymerase reaction directly in Huh 7 or HepG2 cells. AT-130 inhibits HBV DNA replication in hepatoma cells but has no effect on viral DNA polymerase activity or core protein translation[3].
AT-130 (2.5, 18.5 uM) has no effect on total HBV RNA production but does reduce encapsidated RNA. AT-130 does not affect core protein or nucleocapsid production and the activity of the protein expression vector[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

488.33

Formula

C₂₂H₂₂BrN₃O₅

CAS No.
SMILES

O=C(N/C(C(N1CCCCC1)=O)=C(Br)\C2=CC=CC=C2OC)C3=CC=C([N+]([O-])=O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (51.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0478 mL 10.2390 mL 20.4780 mL
5 mM 0.4096 mL 2.0478 mL 4.0956 mL
10 mM 0.2048 mL 1.0239 mL 2.0478 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AT-130AT130AT 130DNA/RNA SynthesisHBVHepatitis B virusWtrtL180MrtM204IHepG2Huh-7coreRNAInhibitorinhibitorinhibit

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AT-130
Cat. No.:
HY-100028
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