PSI
Based on 2 publication(s) in Google Scholar
PSI (Proteasome Inhibitor 1) is a potent proteasome inhibitor. PSI inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI has the potential for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas.
For research use only. We do not sell to patients.
- CAS No.: 158442-41-2
- Formula: C32H50N4O8
- Molecular Weight:618.76
-
Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
HY-13259
MG-132Proteasome Inhibitor -
HY-19312
3-MethyladenineAutophagy/PI3K Inhibitor -
HY-18964
MG-101Cysteine Protease Inhibitor -
HY-13821
EpoxomicinProteasome Inhibitor -
HY-10455
CarfilzomibProteasome Inhibitor -
HY-13207
ONX-0914Proteasome Inhibitor -
HY-10454
DelanzomibProteasome Inhibitor -
HY-108552
MG-115Proteasome Inhibitor -
HY-10227
BortezomibProteasome Inhibitor -
HY-100558
Bafilomycin A1V-ATPase Inhibitor -
HY-16594
LactacystinProteasome Inhibitor -
HY-107412
Proteasome inhibitor IX20S Proteasome Inhibitor
Publications Citing Use of MedChemExpress (MCE) PSI
More
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| PC-3 | IC50 |
375 nM
Compound: 3
|
Antiproliferative activity against human PC3 cell line
Antiproliferative activity against human PC3 cell line
|
[PMID: 16686537] |
In Vitro
PSI (24 h) inhibits the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively)[1].
PSI (50 nM; 6 h) increases caspase-3/7 activity by 8-fold compared with control[1].
PSI (50 nM; 6 h) decreases the transcriptional activity of NF-κB by 52%[1].
PSI (1, 5 nM; 3 days) inhibits the growth of BC3 cells at a high concentration (5 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:BC3, BCBL1, Ramos, BJAB cells
-
Concentration:
-
Incubation Time:24 h
-
Result:Inhibited the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively).
-
Cell Line:HBL6 cells
-
Concentration:50 nM
-
Incubation Time:6 h
-
Result:Decreased the NF-κB activity by 52%.
Chemical Information
-
CAS No. 158442-41-2
-
Appearance Solid
-
Molecular Weight 618.76
-
Formula C32H50N4O8
-
Color White to off-white
-
Synonyms
Proteasome Inhibitor 1; Z-Ile-Glu(OtBu)-Ala-Leu-CHO
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Br J Pharmacol
Fenofibrate potentiates the therapeutic efficacy of EZH2 inhibitors on melanoma via TRIM21- and OTUD4-mediated EZH2 ubiquitination. [Abstract]2026 Jun;183(11):2675-2694. PMID: 41652905
Solvent & Solubility
In Vitro:
H2O : < 0.1 mg/mL (adjust pH to 2 with Acetic acid) (insoluble)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PSI Related Classifications
HY-P1258 Related Classifications
Powered by Bioz