SKF 91488 dihydrochloride
Based on 1 Customer Validation
SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a Ki value of 0.9 μM. SKF 91488 dihydrochloride can block histamine metabolism and increase histamine concentrations. SKF 91488 dihydrochloride can increase blood pressure and enhance bronchoconstriction. SKF 91488 can be used for the researches of infection, inflammation and cardiovascular disease, such as Mycoplasma pneumonia and hemorrhagic hypotension.
For research use only. We do not sell to patients.
- Purity: 98.62%
- CAS No.: 68941-21-9
- Formula: C7H19Cl2N3S
- Molecular Weight:248.22
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Anti-Infection Compound Library
HY-L002
-
Epigenetics Compound Library
HY-L005
-
Immunology/Inflammation Compound Library
HY-L007
-
Histone Modification Research Compound Library
HY-L024
-
Reprogramming Compound Library
HY-L039
-
Anti-Cardiovascular Disease Compound Library
HY-L046
-
Anti-Blood Cancer Compound Library
HY-L079
-
Anti-Hematopathy Compound Library
HY-L171
-
MCE Bioactive Compound Library
HY-L001V
-
Methylation Compound Library
HY-L203
-
High-Throughput Bioactive Compound Library
HY-L205
-
Posttranslational Modification Library
HY-L226
All Histone Methyltransferase Isoforms
More
Biological Activity
SKF 91488 (100 μM, 20 mins) eliminates the infection-induced airway hyperresponsiveness to histamine in Mycoplasma -infected pneumonia hamster tracheal segments[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
SKF 91488 (10 μg, i.c.v., 5 mins before bleeding) does not affect the blood volume required to reduce MAP to 60 mmHg but significantly increases the blood volume required to reduce MAP to 40 mmHg and 20 mmHg in Wistar rats[1].
SKF 91488 (10 μg, i.c.v.) significantly increases histamine concentrations in the hypothalamus and medulla oblongata in Wistar rats[1].
SKF 91488 (10 mM, aerosolized inhalation, 90 breaths per administration, 15 mins before OA challenge) potentiates ovalbumin (OA)-induced bronchoconstriction in OA-sensitized Hartley guinea pigs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Wistar rats[1]
-
Dosage:20, 50 and 100 μg
-
Administration:Intra-cerebroventricularly injection
-
Result:Increased mean arterial pressure (MAP) and heart rate (HR) with onset within 5 min post-administration, peak at 10-20 min, and effect duration of 20-40 min.
Chemical Information
-
CAS No. 68941-21-9
-
Appearance Solid
-
Molecular Weight 248.22
-
Formula C7H19Cl2N3S
-
Color White to off-white
-
SMILES
N=C(N)SCCCCN(C)C.Cl.Cl
-
Synonyms
Homodimaprit dihydrochloride
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
-
Data Sheet (269 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
[1]. Jochem J, et al. Influence of SKF 91488, histamine N-methyltransferase inhibitor, on the central cardiovascular regulation during controlled, stepwise hemorrhagic hypotension in rats. Pol J Pharmacol. 2002 May-Jun;54(3):237-44. [Content Brief]
[2]. Sekizawa K, et al. Histamine N-methyltransferase modulates histamine- and antigen-induced bronchoconstriction in guinea pigs in vivo. Am Rev Respir Dis. 1993 Jan;147(1):92-6. [Content Brief]
[3]. Tamaoki J, et al. Airway hyperresponsiveness to histamine in mycoplasmal infection: role of histamine N-methyltransferase. Eur J Pharmacol. 1998 Apr 24;347(2-3):257-60. [Content Brief]
[4]. Beaven MA, et, al. Inhibition of histamine methylation in vivo by the dimaprit analog, SKF Compound 91488. Agents Actions. 1979 Dec;9(5-6):455-60. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SKF 91488 dihydrochloride Related Classifications
HY-100967 Related Classifications
Powered by Bioz