68941-21-9
Chemical Structure
SKF 91488 dihydrochloride
Synonym(s): Homodimaprit dihydrochloride
- CAS No.: 68941-21-9
- Formula:C7H19Cl2N3S
- Molecular Weight:248.22
IUPAC Name: 4-(dimethylamino)butyl carbamimidothioate dihydrochloride
InChIKey: NPLHSMBWWIIWAQ-UHFFFAOYSA-N
SMILES: N=C(N)SCCCCN(C)C.Cl.Cl
Biological Activity: SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a Ki value of 0.9 μM. SKF 91488 dihydrochloride can block histamine metabolism and increase histamine concentrations. SKF 91488 dihydrochloride can increase blood pressure and enhance bronchoconstriction. SKF 91488 can be used for the researches of infection, inflammation and cardiovascular disease, such as Mycoplasma pneumonia and hemorrhagic hypotension[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
SKF 91488 dihydrochloride | 98.62% | SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a Ki value of 0.9 μM. SKF 91488 dihydrochloride can block histamine metabolism and increase histamine concentrations. SKF 91488 dihydrochloride can increase blood pressure and enhance bronchoconstriction. SKF 91488 can be used for the researches of infection, inflammation and cardiovascular disease, such as Mycoplasma pneumonia and hemorrhagic hypotension. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Jochem J, et al. Influence of SKF 91488, histamine N-methyltransferase inhibitor, on the central cardiovascular regulation during controlled, stepwise hemorrhagic hypotension in rats. Pol J Pharmacol. 2002 May-Jun;54(3):237-44. [Content Brief]
- [2]. Sekizawa K, et al. Histamine N-methyltransferase modulates histamine- and antigen-induced bronchoconstriction in guinea pigs in vivo. Am Rev Respir Dis. 1993 Jan;147(1):92-6. [Content Brief]
- [3]. Tamaoki J, et al. Airway hyperresponsiveness to histamine in mycoplasmal infection: role of histamine N-methyltransferase. Eur J Pharmacol. 1998 Apr 24;347(2-3):257-60. [Content Brief]
- [4]. Beaven MA, et, al. Inhibition of histamine methylation in vivo by the dimaprit analog, SKF Compound 91488. Agents Actions. 1979 Dec;9(5-6):455-60. [Content Brief]
Keywords
