1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
    NO Synthase
  3. Dimaprit dihydrochloride

Dimaprit dihydrochloride 

Cat. No.: HY-B1478
Handling Instructions

Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC50 of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion.

For research use only. We do not sell to patients.

Dimaprit dihydrochloride Chemical Structure

Dimaprit dihydrochloride Chemical Structure

CAS No. : 23256-33-9

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Description

Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC50 of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion[1][2].

IC50 & Target[1][2]

H2 Receptor

 

nNOS

49 μM (IC50)

In Vitro

Dimaprit has less than 0.0001% the activity of histamine on H1-receptors[1].
Dimaprit (0.1 nM-100 μM) inhibits nNOS concentration dependently with an IC50 of 49±14 μM[2].

In Vivo

Dimaprit stimulates gastric acid secretion in rats (1.25 μM/kg/min; rapid i.v. injection), cats (2-64 μM/h; i.v.) and dogs (1-100 nM/kg/min; i.v.)[1].
Dimaprit (0.01-1 μM/kg; i.v. at intervals of 5 min) causes dose-dependent falls in blood pressure in cats. Dimaprit (1-100 nM; intra-arterial injection) causes vasodilatation in the femoral vascular bed, and it (1 μM/kg; bolus or intravenous injection) has no effect on heart rate[1].

Molecular Weight

234.19

Formula

C₆H₁₇Cl₂N₃S

CAS No.

23256-33-9

SMILES

NC(SCCCN(C)C)=N.[H]Cl.[H]Cl

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DimapritHistamine ReceptorNO SynthaseNitric oxide synthasesNOShistamineH2receptornNOSgastricacidInhibitorinhibitorinhibit

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Dimaprit dihydrochloride
Cat. No.:
HY-B1478
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