Dimaprit dihydrochloride 

Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC₅₀ of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion^[1][2].

Dimaprit has less than 0.0001% the activity of histamine on H1-receptors^[1].
Dimaprit (0.1 nM-100 μM) inhibits nNOS concentration dependently with an IC₅₀ of 49±14 μM^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dimaprit stimulates gastric acid secretion in rats (1.25 μM/kg/min; rapid i.v. injection), cats (2-64 μM/h; i.v.) and dogs (1-100 nM/kg/min; i.v.)^[1].
Dimaprit (0.01-1 μM/kg; i.v. at intervals of 5 min) causes dose-dependent falls in blood pressure in cats. Dimaprit (1-100 nM; intra-arterial injection) causes vasodilatation in the femoral vascular bed, and it (1 μM/kg; bolus or intravenous injection) has no effect on heart rate^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

234.19

C₆H₁₇Cl₂N₃S

23256-33-9

NC(SCCCN(C)C)=N.[H]Cl.[H]Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Parsons ME, et, al. Dimaprit -(S-[3-(N,N-dimethylamino)prophyl]isothiourea) - a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology. Agents Actions. 1977 Mar; 7(1): 31-7.  [Content Brief]

  [2]. Paquay JB, et, al. Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br J Pharmacol. 1999 May; 127(2): 331-4.  [Content Brief]