2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-177699
    Fusidic acid prodrug 3025356-77-5 98%
    Fusidic acid prodrug is an antibacterial agent. Fusidic acid prodrug has significant antibacterial activity against Pseudomonas aeruginosa (MIC = 4 µg/mL). Fusidic acid prodrug can be used in the research of infectious conditions.
    Fusidic acid prodrug
  • HY-177745
    25-Azacoprostane 37106-88-0
    25-Azacoprostane (5β-Cholan-24-dimethylamine) is an azasteroid. 25-Azacoprostane has significant inhibitory activity against the molting and metamorphosis processes of various insects. 25-Azacoprostane can be used as insecticide.
    25-Azacoprostane
  • HY-177773
    5-Hydroxymethyl flucloxacillin 75524-31-1
    5-Hydroxymethyl flucloxacillin is an active metabolite of Flucloxacillin (HY-A0246). 5-Hydroxymethyl flucloxacillin exhibits antibacterial activity.
    5-Hydroxymethyl flucloxacillin
  • HY-177784
    iDeg-3
    iDeg-3 is a selective molecular glue degrader that targets IDO1. iDeg-3 can competitively bind to the heme binding site of apo-IDO1, preventing heme binding and inhibiting the enzymatic reaction that converts tryptophan into kynurenine by IDO1 (IC50 = 46 nM). iDeg-3 can be used for the researches of cancer, infection and neurological disease, such as melanoma.
    iDeg-3
  • HY-177785
    iDeg-6
    iDeg-6 is a selective molecular glue degrader that targets IDO1 with a DC50 of 6.5 nM. iDeg-6 can competitively bind to the heme binding site of apo-IDO1, preventing heme binding and inhibiting the enzymatic reaction that converts tryptophan into kynurenine by IDO1 (IC50 = 1.6 μM). iDeg-6 can be used for the researches of cancer, infection and neurological disease, such as melanoma.
    iDeg-6
  • HY-177805
    Tetracycline aptamer sodium
    Tetracycline aptamer sodium is a 57mer-RNA aptamer that targets tetracycline.
    Tetracycline aptamer sodium
  • HY-177813
    148.1-38m sodium
    148.1-38m sodium, an RNA aptamer, inhibits HIV-1 reverse transcriptase (RT) and interfere with viral replication.
    148.1-38m sodium
  • HY-177815
    R-1 sodium
    R-1 sodium is a RNA aptamer that bind to Non-structural protein 1 (NS1) (Kd = 1.62 ± 0.30 nM). R-1 sodium inhibits the interaction of NS1 with tripartite motif-containing protein 25 (TRIM25), and suppression of NS1 enabled retinoic acid inducible gene I (
    R-1 sodium
  • HY-177816
    R-2 sodium
    R-2 sodium is a RNA aptamer that bind to Non-structural protein 1 (NS1) (Kd = 1.92 ± 0.27 nM). R-2 sodium inhibits the interaction of NS1 with tripartite motif-containing protein 25 (TRIM25), and suppression of NS1 enabled retinoic acid inducible gene I (
    R-2 sodium
  • HY-177822
    CD4 aptamer sodium
    CD4 aptamer sodium is a single-strand DNA aptamer that targets CD4. It significantly blocks the interaction between viral gp120 and CD4-expressing cells
    CD4 aptamer sodium
  • HY-177852
    Anthranilyl-AMSN 873556-29-7 98%
    Anthranilyl-AMSN is a potent PqsA inhibitor, with a Kiapp of 170 nM. Anthranilyl-AMSN decreases HHQ and PQS production. Anthranilyl-AMSN can be used in the research of Pseudomonas aeruginosa infections.
    Anthranilyl-AMSN
  • HY-177881
    Savirin 2163006-04-8 98%
    Savirin exhibits in vitro antibacterial and antibiofilm activity. Savirin can prevent skin infections induced by S. aureus in vivo. Savirin shows enhanced activity when combined with antibiotics.
    Savirin
  • HY-177958
    ACS03 2227022-64-0
    ACS03 is a hybrid thiophene-acridine compound. ACS03 induces an increase in lactate dehydrogenase, glutathione S-transferase, and AChE activities. ACS03 has antileishmanial activity. ACS03 exhibits selective anti-cancer effects against colon carcinoma.
    ACS03
  • HY-178025
    TDI-014925 3052313-53-5
    TDI-014925 (Compound 58) is a SARS-CoV-2 methyltransferase nonstructural protein 14 (NSP14) inhibitor with an IC50 of 0.2 nM. TDI-014925 has an antiviral activity with significant microsomal stability and no CYP inhibitory activity. TDI-014925 can be used for COVID-19 research.
    TDI-014925
  • HY-178088
    L-731120 2232226-16-1 98%
    L-731120 is an alkyl citrate zargozaga acid A analogue, which is secondary metabolite produced by fungal fermentation. L-731120 shows inhibitory activity against squalene synthase (SQS) (IC50 = 260 nM). L-731120 can inhibit the synthesis of cholesterol in the liver. L-731120 can be used for the research of infection and metabolic disease, such as hypercholesterolemia.
    L-731120
  • HY-178135
    SCR005 2409183-70-4
    SCR005 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR005 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR005 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR005 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR005 can be used for the study and prevention of enveloped virus pandemics.
    SCR005
  • HY-178137
    SCR007 2409183-72-6
    SCR007 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR007 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR007 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR007 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR007 can be used for the study and prevention of enveloped virus pandemics.
    SCR007
  • HY-178151
    CGR-50 3098857-57-6 98%
    CGR-50 is a potent RSV fusion glycoprotein (F protein) inhibitor (EC50 = 32.6 nM against RSV A2 in HEp-2 cells). CGR-50 blocks RSV entry by binding to the F protein and inhibiting membrane fusion. CGR-50 can be used for RSV infection research.
    CGR-50
  • HY-178156
    DHODH-IN-31 99.55%
    DHODH-IN-31 is a human dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.59 μM. DHODH-IN-31 exhibits antiviral activity. DHODH-IN-31 can be used for the research of infection, such as SARS-CoV-2.
    DHODH-IN-31
  • HY-178160
    SARS-CoV-2 PLpro-IN-2 1581755-42-1 98%
    SARS-CoV-2 PLpro-IN-2 (Compound 12) is a highly selective SARS-CoV-2 papain-like protease (PLpro) inhibitor of (IC50=0.06 μM). SARS-CoV-2 PLpro-IN-2 inhibits viral replication and immune evasion. SARS-CoV-2 PLpro-IN-2 exhibits antiviral efficacy in HeLa-ACE2 cells (EC50=2.9 μM). SARS-CoV-2 PLpro-IN-2 is promising for research of COVID-19.
    SARS-CoV-2 PLpro-IN-2
Cat. No. Product Name / Synonyms Application Reactivity