SCR007
SCR007 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR007 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR007 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR007 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR007 can be used for the study and prevention of enveloped virus pandemics.
For research use only. We do not sell to patients.
- CAS No.: 2409183-72-6
- Formula: C36H30N4S4
- Molecular Weight:646.91
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Vero | IC50 |
>100 μM
Compound: SCR-9
|
Antiviral activity against Zika virus harboring subgenomic GFP replicon infected in African green monkey Vero cells assessed as reduction in viral infection preincubated for 30 mins followed by viral infection and measured after 72 hrs
Antiviral activity against Zika virus harboring subgenomic GFP replicon infected in African green monkey Vero cells assessed as reduction in viral infection preincubated for 30 mins followed by viral infection and measured after 72 hrs
|
[PMID: 30925051] |
In Vitro
SCR007 (10-40 μM) ) inhibits infection of SARS-CoV-2 (WA.1 strain), MERS-CoV, EBOV, MARV, NiV, and HeV in PRNT and IFA assays, with potent inhibitory efficacy[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:hACE2 knock-in mice (4-5-month-old) were intranasally challenged with 2 × 103 PFU of SARS-CoV-1/2[1]
-
Dosage:3 mg/kg
-
Administration:i.n., single dose
-
Result:Achieved 90% survival rate.
Reduced lung viral RNA copies by multiple orders of magnitude and brain viral RNA copies significantly.
Decreased perivascular infiltrates and necrotic neurons in lung and brain tissues.
Reduced lung live virus titer.
Decreased pro-inflammatory cytokine levels in bronchoalveolar lavage fluid (BALF), with TNFα, IL-18 and IFN-γ reduced.
Chemical Information
-
CAS No. 2409183-72-6
-
Molecular Weight 646.91
-
Formula C36H30N4S4
-
SMILES
C1(C/N=C/C2=CC=CS2)=CC(C3=CC(C/N=C/C4=CC=CS4)=CC(C/N=C/C5=CC=CS5)=C3)=CC(C/N=C/C6=CC=CS6)=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SCR007 Related Classifications
HY-178137 Related Classifications
Powered by Bioz