DHODH-IN-31
Based on 1 Customer Validation
DHODH-IN-31 is a human dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.59 μM. DHODH-IN-31 exhibits antiviral activity. DHODH-IN-31 can be used for the research of infection, such as SARS-CoV-2.
For research use only. We do not sell to patients.
- Purity: 99.55%
- Formula: C20H15N3O
- Molecular Weight:313.35
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Anti-Infection Compound Library
HY-L002
-
Metabolism/Protease Compound Library
HY-L012
-
Antiviral Compound Library
HY-L027
-
Ferroptosis Compound Library
HY-L051
-
Mitochondria-Targeted Compound Library
HY-L089
-
Metabolic Enzyme Compound Library
HY-L146
-
Multi-Target Compound Library
HY-L176
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
|
hDHODH 0.59 μM (IC50) |
SARS-CoV-2 0.15 μM (EC50) |
DHODH-IN-31 (Compound 10e) exhibits antiviral activity against SARS-CoV-2 with an EC50 of 0.15 μM[1].
DHODH-IN-31 shows CC50 values of 26 and 180 μM in Vero and SH-SY5Y cells[1].
DHODH-IN-31 (0.01-10 μM) inhibits SARS-CoV-2 viral replication in Calu-3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Appearance Solid
-
Molecular Weight 313.35
-
Formula C20H15N3O
-
Color White to off-white
-
SMILES
O=C1NC(NC2=CC(C3=CC=CC=C3)=CC=C2)=NC4=C1C=CC=C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (398.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1913 mL | 15.9566 mL | 31.9132 mL | 79.7830 mL |
| 5 mM | 0.6383 mL | 3.1913 mL | 6.3826 mL | 15.9566 mL | |
| 10 mM | 0.3191 mL | 1.5957 mL | 3.1913 mL | 7.9783 mL | |
| 15 mM | 0.2128 mL | 1.0638 mL | 2.1275 mL | 5.3189 mL | |
| 20 mM | 0.1596 mL | 0.7978 mL | 1.5957 mL | 3.9891 mL | |
| 25 mM | 0.1277 mL | 0.6383 mL | 1.2765 mL | 3.1913 mL | |
| 30 mM | 0.1064 mL | 0.5319 mL | 1.0638 mL | 2.6594 mL | |
| 40 mM | 0.0798 mL | 0.3989 mL | 0.7978 mL | 1.9946 mL | |
| 50 mM | 0.0638 mL | 0.3191 mL | 0.6383 mL | 1.5957 mL | |
| 60 mM | 0.0532 mL | 0.2659 mL | 0.5319 mL | 1.3297 mL | |
| 80 mM | 0.0399 mL | 0.1995 mL | 0.3989 mL | 0.9973 mL | |
| 100 mM | 0.0319 mL | 0.1596 mL | 0.3191 mL | 0.7978 mL |
DHODH-IN-31 Related Classifications
HY-178156 Related Classifications
Powered by Bioz