2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-126773
    Dp2mT 741250-22-6 98%
    Dp2mT is a non-cytotoxic control compound, with an IC50 of >3 μM for HIV-1 transcription inhibition and an IC50 of >10 μM for cytotoxicity. Dp2mT does not bind to intracellular iron pools. Dp2mT does not inhibit CDK9 activity.
    Dp2mT
  • HY-126802
    Saquayamycin B1 99260-68-1 98%
    Saquayamycin B1 has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin B1 has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells.
    Saquayamycin B1
  • HY-126803
    Saquayamycin B 99260-67-0 98%
    Saquayamycin B (compound 3) is a new angucycline antibiotic. Saquayamycin B has antitumor activities against a human lung (H-460) and a human breast cancer cell line (MCF-7) with GI50 values of 12.2 and 15.2 µM respectively .
    Saquayamycin B
  • HY-126877
    3-Deaza-2'-deoxyadenosine 78582-17-9
    3-Deaza-2 '-deoxyadenosine is a nucleoside analog synthesized from 2' -deoxyadenosine. 3-Deaza-2 '-deoxyadenosine inhibits RNA synthesis by binding to ribose fragments of ribonucleotides, thereby preventing the formation of enzyme-substrate complexes, thereby preventing chain elongation, It can also inhibit DNA synthesis by binding deoxyribose fragments of DNA and preventing DNA polymerase from adding nucleotides to the growth chain. 3-Deaza-2 '-deoxyadenosine has antiviral activity.
    3-Deaza-2'-deoxyadenosine
  • HY-126878
    11-Oxahomoaminopterin 78520-72-6 98%
    11-Oxahomoaminopterin shows antifolate activity and inhibits Lactobacillus casei DHFFZ with antimicrobial and antitumor activities.
    11-Oxahomoaminopterin
  • HY-126914
    Diacetylcercosporin 62574-06-5 98%
    Diacetylcercosporin is a perylenequinone produced by Cercospora and Septoria that has diverse biological activities. Diacetylcercosporin inhibits the growth of P. falciparum strains that are sensitive and resistant to chloroquine (IC50s=2.75 and 1.94 μM for D6 and W2 clones, respectively) and L. donovani parasites (IC50=3.1 μM) in vitro. Diacetylcercosporin exhibits cytotoxicity against SK-MEL, KB, BT549, and SKOV3 human cancer cell lines (IC50s=4.8-8.7 μM). Diacetylcercosporin is also a phytotoxin that inhibits the growth of lettuce and bentgrass at a concentration of 1.62 mM.
    Diacetylcercosporin
  • HY-126954
    13-Deoxycarminomycin 76034-18-9 98%
    13-Deoxycarminomycin is an antibiotic with antibacterial activity. 13-Deoxycarminomycin also exhibits cytotoxicity against tumor cells such as HeLa and P388, and can play an anti-tumor role.
    13-Deoxycarminomycin
  • HY-127014
    Julimycin B2 18126-05-1 98%
    Julimycin B2 has anti-Gram-positive bacteria and anti-virus activity and it has effects on ehrman ascites carcinoma in mice.
    Julimycin B2
  • HY-127020
    Deoxyenterocin 108605-51-2 98%
    Deoxyenterocin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibiotic, antiviral, and antioxidant properties. It inhibits the growth of S. lutea, S. aureus, K. pneumoniae, and V. percolans in vitro when used at a concentration of 500 μg/mL. Deoxyenterocin (50 μg/mL) inhibits the cytopathic effect of influenza A H1N1 virus by 60.6% in vitro. It also prevents hydrogen peroxide-induced decreases in glutathione (GSH) levels and in the mitochondrial membrane potential in mouse primary cortical neuronal cultures when used at a concentration of 1 μM.
    Deoxyenterocin
  • HY-127028
    Tripynadine 81849-98-1 98%
    Tripynadine is an anti-malarial compound with oral activity.
    Tripynadine
  • HY-127072
    Amicoumacin A 78654-44-1 98%
    Amicoumacin A is an orally active antibiotic. Amicoumacin A targets bacterial ribosomes and inhibits bacterial translation by stabilizing the interaction between mRNA and ribosomes. Amicoumacin A induces cancer cell death by targeting eukaryotic ribosomes. Amicoumacin A exhibits anti-inflammatory and anti-ulcer activities, inhibits carrageenan-induced paw edema, and prevents stress-induced gastric ulcers. Amicoumacin A inhibits the growth of Gram-positive bacteria, Salmonella spp., Shigella spp., Helicobacter pylori, and methicillin-resistant Staphylococcus aureus. Amicoumacin A can be used in the research of lung cancer, breast cancer, bacterial infections, inflammatory edema and gastric ulcers[2].
    Amicoumacin A
  • HY-127131
    Leucanicidin 91021-66-8 98%
    Leucanicidin is a macrolide bacterial metabolite originally isolated from S. halstedii. It is toxic to L. separata fourth instar larvae when used at a concentration of 20 ppm and to H. contortus, T. colubriformis, and O. circumcincta larvae (LD50s=0.23-0.42 μg/mL).
    Leucanicidin
  • HY-127140
    Cardanol triene 79353-39-2 98%
    Cardanol triene is a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 40.5 μM in vitro. A mixture of cardanol mono-, di-, and triene is used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.
    Cardanol triene
  • HY-127158
    Fenaminosulf 140-56-7 98%
    Fenaminosulf is a plant immune modulator and mutagen. Fenaminosulf impairs plant immune recognition and signal transduction by inhibiting the activities of key kinases such as Xa21 and PBL19, thereby regulating the expression of genes related to hormone metabolism, phenylpropane biosynthesis, and plant-pathogen interactions. Fenaminosulf affects the growth and gall formation of Zizania latifolia in a concentration-dependent manner. Fenaminosulf induces mutations in bacterial systems and causes plant chromosome aberrations, but shows no mutagenic activity or lethal effect in Drosophila melanogaster. Fenaminosulf exhibits inconsistent carcinogenicity in rat studies.
    Fenaminosulf
  • HY-127179
    ML189 337328-21-9 98%
    ML189 is an HSP90 inhibitor. ML189 can be used in the research of infectious diseases such as candidiasis.
    ML189
  • HY-127183
    ML229 898918-58-6 98%
    ML229 is an HSP90 inhibitor. ML229 can be used in the research of infectious diseases such as candidiasis.
    ML229
  • HY-12772A
    rel-Hydroxy Itraconazole 207970-87-4 98%
    rel-Hydroxy Itraconazole (rel-R-63373) is a relative stereoisomer of Hydroxy Itraconazole. Hydroxy Itraconazole is the major active metabolite of the antifungal compound Itraconazole (HY-17514).
    rel-Hydroxy Itraconazole
  • HY-12785R
    Albendazole sulfoxide (Standard) 54029-12-8
    Albendazole sulfoxide (Standard) is the analytical standard of Albendazole sulfoxide. This product is intended for research and analytical applications. Albendazole sulfoxide (Ricobendazole), the main active metabolite of Albendazole, exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.
    Albendazole sulfoxide (Standard)
  • HY-128049
    ML121 1212185-26-6 98%
    ML121 is a selective and potent VIM-2 inhibitor with an IC50 of 54 nM and a Ki of 148 nM. ML121 shows inactive in IMP-1 and TEM-1 beta-lactamase assays. ML121 can potentiate the antibiotic activity of Imipenem (HY-B1369A) in VIM-2 transformed E.coli.
    ML121
  • HY-128189
    Aminoacyl tRNA synthetase-IN-4 342017-94-1 98%
    Aminoacyl tRNA synthetase-IN-4 (Compound 1l) is an inhibitor of Aminoacyl tRNA synthetase, with an IC50 of 0.026 μM for C.albicans prolyl-tRNA synthetase. Aminoacyl tRNA synthetase-IN-4 can be used for antifungal research.
    Aminoacyl tRNA synthetase-IN-4
Cat. No. Product Name / Synonyms Application Reactivity