2. Anti-infection
  3. Antibiotic
  4. Saquayamycin B

Saquayamycin B (compound 3) is a new angucycline antibiotic. Saquayamycin B has antitumor activities against a human lung (H-460) and a human breast cancer cell line (MCF-7) with GI50 values of 12.2 and 15.2 µM respectively .

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Saquayamycin B

Saquayamycin B Chemical Structure

CAS No. : 99260-67-0

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Saquayamycin B Related Antibodies

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Description

Saquayamycin B (compound 3) is a new angucycline antibiotic. Saquayamycin B has antitumor activities against a human lung (H-460) and a human breast cancer cell line (MCF-7) with GI50 values of 12.2 and 15.2 µM respectively [1].

Cellular Effect
Cell Line Type Value Description References
MCF7 GI50
15.2 μM
Compound: 3
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
[PMID: 18666798]
NCI-H460 GI50
12.2 μM
Compound: 3
Cytotoxicity against human H460 cells after 48 hrs by SRB assay
Cytotoxicity against human H460 cells after 48 hrs by SRB assay
[PMID: 18666798]
NCI-H460 GI50
3.929 μM
Compound: 8
Growth inhibition of human NCI-H460 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay
Growth inhibition of human NCI-H460 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay
[PMID: 22758660]
PC-3 GI50
0.07454 μM
Compound: 8
Growth inhibition of human PC3 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay
Growth inhibition of human PC3 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay
[PMID: 22758660]
Molecular Weight

820.83

Formula

C43H48O16
CAS No.
SMILES

O=C1C[C@@](O[C@H]2CC[C@H](O[C@H]3C=CC([C@H](C)O3)=O)[C@H](C)O2)(C)C[C@]4(O)[C@@]1(O)C(C(C5=CC=C([C@H]6C[C@@]7([H])O[C@](CC([C@H](C)O8)=O)([H])[C@]8([H])O[C@]7([H])[C@@H](C)O6)C(O)=C5C9=O)=O)=C9C=C4
Structure Classification
Initial Source

Streptomyces sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Saquayamycin B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Saquayamycin B99260-67-0Antibioticantibiotichuman lung (H-460) ;human breast cancer cell line (MCF-7)Inhibitorinhibitorinhibit

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