Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002

  • J Nat Prod. 2008 Sep;71(9):1569-73. doi: 10.1021/np800281f.
Mohamed S Abdelfattah  1 ,  Madan Kumar Kharel ,  John Andrew Hitron ,  Irfan Baig ,  Jürgen Rohr
Affiliations
  • 1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, Kentucky 40536-0082, USA.
PMID: 18666798 DOI: 10.1021/np800281f
Abstract

Two new anticancer Antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate Extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human Lung Cancer and MCF-7 human Breast Cancer cells.

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