3-Deaza-2'-deoxyadenosine
Based on 1 Customer Validation
3-Deaza-2 '-deoxyadenosine is a nucleoside analog synthesized from 2' -deoxyadenosine. 3-Deaza-2 '-deoxyadenosine inhibits RNA synthesis by binding to ribose fragments of ribonucleotides, thereby preventing the formation of enzyme-substrate complexes, thereby preventing chain elongation, It can also inhibit DNA synthesis by binding deoxyribose fragments of DNA and preventing DNA polymerase from adding nucleotides to the growth chain. 3-Deaza-2 '-deoxyadenosine has antiviral activity.
For research use only. We do not sell to patients.
- Purity: 95.60%
- CAS No.: 78582-17-9
- Formula: C11H14N4O3
- Molecular Weight:250.25
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 78582-17-9
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Appearance Solid
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Molecular Weight 250.25
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Formula C11H14N4O3
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Color Light brown to brown
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SMILES
O[C@H]1C[C@H](N2C=NC3=C2C=CN=C3N)O[C@@H]1CO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (199.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Hendrickson CL, et al. Probing minor groove recognition contacts by DNA polymerases and reverse transcriptases using 3-deaza-2'-deoxyadenosine. Nucleic Acids Res. 2004 Apr 23;32(7):2241-50. [Content Brief]
[2]. Cristalli G, et al. Synthesis and biological evaluation of N6-cycloalkyl derivatives of 1-deazaadenine nucleosides: a new class of anti-human immunodeficiency virus agents. J Med Chem. 1995 Sep 29;38(20):4019-25. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9960 mL | 19.9800 mL | 39.9600 mL | 99.9001 mL |
| 5 mM | 0.7992 mL | 3.9960 mL | 7.9920 mL | 19.9800 mL | |
| 10 mM | 0.3996 mL | 1.9980 mL | 3.9960 mL | 9.9900 mL | |
| 15 mM | 0.2664 mL | 1.3320 mL | 2.6640 mL | 6.6600 mL | |
| 20 mM | 0.1998 mL | 0.9990 mL | 1.9980 mL | 4.9950 mL | |
| 25 mM | 0.1598 mL | 0.7992 mL | 1.5984 mL | 3.9960 mL | |
| 30 mM | 0.1332 mL | 0.6660 mL | 1.3320 mL | 3.3300 mL | |
| 40 mM | 0.0999 mL | 0.4995 mL | 0.9990 mL | 2.4975 mL | |
| 50 mM | 0.0799 mL | 0.3996 mL | 0.7992 mL | 1.9980 mL | |
| 60 mM | 0.0666 mL | 0.3330 mL | 0.6660 mL | 1.6650 mL | |
| 80 mM | 0.0500 mL | 0.2498 mL | 0.4995 mL | 1.2488 mL | |
| 100 mM | 0.0400 mL | 0.1998 mL | 0.3996 mL | 0.9990 mL |
3-Deaza-2'-deoxyadenosine Related Classifications
HY-126877 Related Classifications
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