78582-17-9
Chemical Structure
3-Deaza-2'-deoxyadenosine
- CAS No.: 78582-17-9
- Formula:C11H14N4O3
- Molecular Weight:250.25
IUPAC Name: (2R,3S,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
InChIKey: KMQPIRJQPAVGJL-DJLDLDEBSA-N
SMILES: O[C@H]1C[C@H](N2C=NC3=C2C=CN=C3N)O[C@@H]1CO
Biological Activity: 3-Deaza-2 '-deoxyadenosine is a nucleoside analog synthesized from 2' -deoxyadenosine. 3-Deaza-2 '-deoxyadenosine inhibits RNA synthesis by binding to ribose fragments of ribonucleotides, thereby preventing the formation of enzyme-substrate complexes, thereby preventing chain elongation, It can also inhibit DNA synthesis by binding deoxyribose fragments of DNA and preventing DNA polymerase from adding nucleotides to the growth chain. 3-Deaza-2 '-deoxyadenosine has antiviral activity[1][2].
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3-Deaza-2'-deoxyadenosine | 95.60% | 3-Deaza-2 '-deoxyadenosine is a nucleoside analog synthesized from 2' -deoxyadenosine. 3-Deaza-2 '-deoxyadenosine inhibits RNA synthesis by binding to ribose fragments of ribonucleotides, thereby preventing the formation of enzyme-substrate complexes, thereby preventing chain elongation, It can also inhibit DNA synthesis by binding deoxyribose fragments of DNA and preventing DNA polymerase from adding nucleotides to the growth chain. 3-Deaza-2 '-deoxyadenosine has antiviral activity. | ||||||||||||||||||||
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- [1]. Hendrickson CL, et al. Probing minor groove recognition contacts by DNA polymerases and reverse transcriptases using 3-deaza-2'-deoxyadenosine. Nucleic Acids Res. 2004 Apr 23;32(7):2241-50. [Content Brief]
- [2]. Cristalli G, et al. Synthesis and biological evaluation of N6-cycloalkyl derivatives of 1-deazaadenine nucleosides: a new class of anti-human immunodeficiency virus agents. J Med Chem. 1995 Sep 29;38(20):4019-25. [Content Brief]
Keywords
