ML121
ML121 is a selective and potent VIM-2 inhibitor with an IC50 of 54 nM and a Ki of 148 nM. ML121 shows inactive in IMP-1 and TEM-1 beta-lactamase assays. ML121 can potentiate the antibiotic activity of Imipenem (HY-B1369A) in VIM-2 transformed E.coli.
For research use only. We do not sell to patients.
- CAS No.: 1212185-26-6
- Formula: C16H16N2OS2
- Molecular Weight:316.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Beta-lactamase Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
VIM-2 |
Chemical Information
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CAS No. 1212185-26-6
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Molecular Weight 316.44
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Formula C16H16N2OS2
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SMILES
O=C1SC(C(C2=CC=CN=C2)C3C(C4CCC3C4)S5)=C5N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ML121 Related Classifications
HY-128049 Related Classifications
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