Imipenem
Based on 38 publication(s) in Google Scholar
Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.89%
- CAS. Nr.: 64221-86-9
- Formel: C12H17N3O4S
- Molecular Weight:299.35
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) Imipenem
More- Nat Nanotechnol. 2026 Feb 2. [Abstract]
- Cell Host Microbe. 2024 Jun 12;32(6):964-979.e7. [Abstract]
- Nat Commun. 2023 Mar 22;14(1):1594. [Abstract]
- Nat Commun. 2022 Mar 2;13(1):1116. [Abstract]
- J Cachexia Sarcopenia Muscle. 2023 Jun;14(3):1424-1440. [Abstract]
- Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]
- Emerg Microbes Infect. 2024 Dec;13(1):2321981. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- J Clin Microbiol. 2025 Aug 20:e0084125. [Abstract]
- Commun Biol. 2023 Aug 12;6(1):837. [Abstract]
- Antibiotics (Basel). 2021 Sep 14;10(9):1110. [Abstract]
- Molecules. 2025 Mar 9;30(6):1224. [Abstract]
- Int J Antimicrob Agents. 2025 Sep;66(3):107550. [Abstract]
- Int J Antimicrob Agents. 2022 Nov-Dec;60(5-6):106669. [Abstract]
- Sci Rep. 2022 Oct 7;12(1):16814. [Abstract]
- Microorganisms. 2024 Mar 13;12(3):575. [Abstract]
- iScience. 2025 Mar 28;28(5):112311. [Abstract]
- iScience. 2023 Oct 7;26(11):108158. [Abstract]
- Antimicrob Agents Chemother. 2025 Jul 2;69(7):e0024925. [Abstract]
- Antimicrob Agents Chemother. 2024 Dec 5;68(12):e0094524. [Abstract]
- Antimicrob Agents Chemother. 2024 Feb 7;68(2):e0133223. [Abstract]
- Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0052823. [Abstract]
- J Antimicrob Chemother. 2026 Feb 2;81(3):dkag034. [Abstract]
- J Antimicrob Chemother. 2025 Nov 5:dkaf408. [Abstract]
- Microbiol Spectr. 2025 Jul;13(7):e0307424. [Abstract]
- Microbiol Spectr. 2023 Dec 12;11(6):e0304723. [Abstract]
- J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858. [Abstract]
- Open Forum Infect Dis. 2023 Jan 27;10(2):ofad038. [Abstract]
- J Glob Antimicrob Resist. 2026 Jun 24:S2213-7165(26)00094-9. [Abstract]
- Infect Drug Resist. 2026 May 8;19.
- Infect Drug Resist. 2025 Oct 4:18:5239-5247. [Abstract]
- Eur J Clin Microbiol Infect Dis. 2025 Sep 29. [Abstract]
- Anim Dis. 2021;1(1):26. [Abstract]
- Vet Microbiol. 2024 May:292:110046. [Abstract]
- FEBS Open Bio. 2026 Apr 16. [Abstract]
- Future Microbiol. 2025 Oct 13:1-10. [Abstract]
- Authorea. 2025 Sep 17.
- Res Sq. 2024 Nov 26.
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Biologische Aktivität
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β-lactam |
Pharmacokinetic Parameters of Imipenem in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single)[1].
| Drug and dose(mg/kg) | Cmax(mg/liter) | Tmax(min) | AUCtot(mg min/liter) | Vz/F(ml/kg) | Vss/F (ml/kg) | CL/F(ml/min/kg) | t1/2(min) | MRT(min) |
| Imipenem | ||||||||
| 8 | 15 (7.1) | 21 (11) | 1,470 (777) | 648 (330) | 721 (343) | 6.7 (3) | 67 (11) | 108 (12) |
| 16 | 34 (6) | 28 (18) | 2,857 (559) | 507 (140) | 543 (121) | 5.8 (1) | 60 (9.1) | 94 (10) |
| 32 | 54 (11) | 18 (6.1) | 4,895 (635) | 516 (75) | 566 (83) | 6.6 (0.8) | 54 (6.5) | 86 (11) |
| 64 | 69 (37) | 15 (9.5) | 6,037 (2,976) | 547 (274) | 617 (308) | 7.4 (3.6) | 43 (22) | 70 (35) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Neutropenic mouse model of biofilm lung infection[3]
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Dosage:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg
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Administration:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single
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Result:Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.
Chemical Information
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CAS. Nr. 64221-86-9
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Appearance Solid
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Molecular Weight 299.35
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Formel C12H17N3O4S
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Color Off-white to yellow
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SMILES
O=C(C(N12)=C(SCCNC=N)C[C@]2([H])[C@@H]([C@H](O)C)C1=O)O
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Synonyms
N-Formimidoyl thienamycin; MK0787
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (38)
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Journal Impact Factor
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Most Recent
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Nat Nanotechnol
Ultra-rapid nanoplasmonic colorimetry in microfluidics for antimicrobial susceptibility testing directly from specimens. [Abstract]2026 Feb 2. PMID: 41629481 -
Cell Host Microbe
Candida albicans accelerates atherosclerosis by activating intestinal hypoxia-inducible factor2α signaling. [Abstract]2024 Jun 12;32(6):964-979.e7. PMID: 38754418 -
Nat Commun
2023 Mar 22;14(1):1594. PMID: 36949052 -
Nat Commun
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]2022 Mar 2;13(1):1116. PMID: 35236849 -
J Cachexia Sarcopenia Muscle
2023 Jun;14(3):1424-1440. PMID: 36883680 -
Free Radic Biol Med
Atorvastatin combined with imipenem alleviates lung injury in sepsis by inhibiting neutrophil extracellular trap formation via the ERK/NOX2 signaling pathway. [Abstract]2024 Aug 1:220:179-191. PMID: 38704053
Imipenem purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]
Combination of ATR and IMP effectively inhibits the formation of NETs. After CLP modeling, ATR was administered with Imipenem monohydrate (25 mg/kg, subcutaneously) at 6 and 18 h. The protein levels of Cit-H3 in the lungs were detected by western blot and analyzed by grayscale.
Imipenem purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]
Combination of ATR and IMP effectively inhibits the formation of NETs. After CLP modeling, ATR was administered with Imipenem monohydrate (25 mg/kg, subcutaneously) at 6 and 18 h. Co-localization of Cit-H3, MPO and DAPI was observed by fluorescence microscopy and the level of NETs formation was analyzed (n = 4).
Imipenem purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]
Combination of ATR and IMP alleviates lung injury by inhibiting NETs. Treatments were administered at 6 and 18 h post-CLP modeling with ATR, Imipenem monohydrate (25 mg/kg, subcutaneously), and DNase I. After 24 h, lung tissues were examined for pulmonary injury and NET expression. HE staining and scoring of lung tissue, scale bar = 100 μm.
Imipenem purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]
Combination of ATR and IMP alleviates lung injury by inhibiting NETs. Treatments were administered at 6 and 18 h post-CLP modeling with ATR, Imipenem monohydrate (25 mg/kg, subcutaneously), and DNase I. After 24 h, lung tissues were examined for pulmonary injury and NET expression. Co-localization of Cit-H3, MPO and DAPI in NET was observed using fluorescence microscopy
Imipenem purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]
Imipenem monohydrate (1, 5, 10 μM) was pre-treated with neutrophils for 2 h, followed by stimulation with LPS (5 μg/mL) for 4 h. Cit-H3 was detected by western blot.
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Emerg Microbes Infect
AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria. [Abstract]2024 Dec;13(1):2321981. PMID: 38422452 -
Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
J Clin Microbiol
Luciferase reporter mycobacteriophage (TM4:: GeNL) enables rapid assessment of drug susceptibilities and inducible macrolide resistance in Mycobacterium abscessus complex. [Abstract]2025 Aug 20:e0084125. PMID: 40833127 -
Commun Biol
Bacteria exposed to antiviral drugs develop antibiotic cross-resistance and unique resistance profiles. [Abstract]2023 Aug 12;6(1):837. PMID: 37573457 -
Antibiotics (Basel)
Rapid Detection of Multiple Classes of β-Lactam Antibiotics in Blood Using an NDM-1 Biosensing Assay. [Abstract]2021 Sep 14;10(9):1110. PMID: 34572692 -
Molecules
Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]2025 Mar 9;30(6):1224. PMID: 40142001 -
Int J Antimicrob Agents
In vitro activity of cefepime-zidebactam, ceftolozane-tazobactam, ceftazidime-avibactam, imipenem-relebactam, and other comparators against imipenem-non-susceptible Pseudomonas aeruginosa in Taiwan, 2022. [Abstract]2025 Sep;66(3):107550. PMID: 40480535 -
Int J Antimicrob Agents
In vitro effects of diazabicyclooctane β-lactamase inhibitors relebactam and nacubactam against three subspecies of Mycobacterium abscessus complex. [Abstract]2022 Nov-Dec;60(5-6):106669. PMID: 36064079 -
Sci Rep
Activity of newest generation β-lactam/β-lactamase inhibitor combination therapies against multidrug resistant Pseudomonas aeruginosa. [Abstract]2022 Oct 7;12(1):16814. PMID: 36207358 -
Microorganisms
Antimicrobial Resistance and Genomic Characteristics of Escherichia coli Strains Isolated from the Poultry Industry in Henan Province, China. [Abstract]2024 Mar 13;12(3):575. PMID: 38543626
Imipenem purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575. [Abstract]
Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.
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iScience
The oxacillinase variant, OXA-1152, in Pandoraea sputorum contributes to discrepancies in carbapenem resistance. [Abstract]2025 Mar 28;28(5):112311. PMID: 40454099 -
iScience
Analysis of microbiota reveals the underlying mechanism of PHF11 in the development of Enterococcus-regulated endometriotic cysts. [Abstract]2023 Oct 7;26(11):108158. PMID: 37915596 -
Antimicrob Agents Chemother
An enoyl-ACP reductase inhibitor, NITD-916, expresses anti- Mycobacterium abscessus activity. [Abstract]2025 Jul 2;69(7):e0024925. PMID: 40407337
Imipenem purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2025 Jul 2;69(7):e0024925. [Abstract]
Numbers of organisms treated with 16× MIC NITD-916, 8 mg/L RFB or 16 mg/L IPM at 24 and 48 hours were significantly less than the drug-free control.
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Antimicrob Agents Chemother
2024 Dec 5;68(12):e0094524. PMID: 39470202 -
Antimicrob Agents Chemother
2024 Feb 7;68(2):e0133223. PMID: 38174924 -
Antimicrob Agents Chemother
The in vitro effect of new combinations of carbapenem-β-lactamase inhibitors for Mycobacterium abscessus. [Abstract]2023 Oct 18;67(10):e0052823. PMID: 37671880 -
J Antimicrob Chemother
Comparative activity of established versus new-generation β-lactams against AmpC-hyperproducing clinical isolates of Enterobacter cloacae complex and Klebsiella aerogenes: a multicentre study. [Abstract]2026 Feb 2;81(3):dkag034. PMID: 41648989 -
J Antimicrob Chemother
Unravelling the triad of penicillin-binding proteins, β-lactamase activity, and mRNA dynamics in Pseudomonas aeruginosa AmpC induction. [Abstract]2025 Nov 5:dkaf408. PMID: 41206063 -
Microbiol Spectr
Antimicrobial resistance of rapidly growing mycobacteria isolated from companion animals in Taiwan. [Abstract]2025 Jul;13(7):e0307424. PMID: 40387379 -
Microbiol Spectr
In vitro activity of cefiderocol against Pseudomonas aeruginosa isolated from cystic fibrosis patients. [Abstract]2023 Dec 12;11(6):e0304723. PMID: 37982634 -
J Antimicrob Chemother
In vitro activity of the novel β-lactamase inhibitor taniborbactam (VNRX-5133), in combination with cefepime or meropenem, against MDR Gram-negative bacterial isolates from China. [Abstract]2020 Jul 1;75(7):1850-1858. PMID: 32154866 -
Open Forum Infect Dis
Trends of β-Lactamase Occurrence Among Escherichia coli and Klebsiella pneumoniae in United States Hospitals During a 5-Year Period and Activity of Antimicrobial Agents Against Isolates Stratified by β-Lactamase Type. [Abstract]2023 Jan 27;10(2):ofad038. PMID: 36776778 -
J Glob Antimicrob Resist
In vitro activity of cefiderocol against clinically relevant Gram-negative bacilli collected in China in 2023. [Abstract]2026 Jun 24:S2213-7165(26)00094-9. PMID: 42342122 -
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Infect Drug Resist
In vitro Activity of the Novel Tetracyclines Derivative, Zifanocycline Against Mycobacterium abscessus. [Abstract]2025 Oct 4:18:5239-5247. PMID: 41069760 -
Eur J Clin Microbiol Infect Dis
Evaluation of EUCAST rapid antimicrobial susceptibility testing (RAST) for carbapenemase-producing Klebsiella pneumoniae with focus on KPC variants. [Abstract]2025 Sep 29. PMID: 41023358 -
Anim Dis
Pasteurella multocida capsular: lipopolysaccharide types D:L6 and A:L3 remain to be the main epidemic genotypes of pigs in China. [Abstract]2021;1(1):26. PMID: 34778886 -
Vet Microbiol
Discovery of the tigecycline resistance gene cluster tmexCD3-toprJ1 in Pasteurella multocida strains isolated from pigs in China. [Abstract]2024 May:292:110046. PMID: 38471428 -
FEBS Open Bio
Long-term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis. [Abstract]2026 Apr 16. PMID: 41992425 -
Future Microbiol
2025 Oct 13:1-10. PMID: 41082411 -
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Lösungsmittel & Löslichkeit
H2O : 11.67 mg/mL (38.98 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Johann Motsch, et al. RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections. Clin Infect Dis. 2020 Apr 15;70(9):1799-1808. [Content Brief]
[2]. F P Tally, et al. In vitro activity of N-formimidoyl thienamycin (MK0787). Antimicrob Agents Chemother. 1980 Oct;18(4):642-4. [Content Brief]
[3]. Wang Hengzhuang, et al. In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection. Antimicrob Agents Chemother. 2012 May;56(5):2683-90. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.3406 mL | 16.7029 mL | 33.4057 mL | 83.5143 mL |
| 5 mM | 0.6681 mL | 3.3406 mL | 6.6811 mL | 16.7029 mL | |
| 10 mM | 0.3341 mL | 1.6703 mL | 3.3406 mL | 8.3514 mL | |
| 15 mM | 0.2227 mL | 1.1135 mL | 2.2270 mL | 5.5676 mL | |
| 20 mM | 0.1670 mL | 0.8351 mL | 1.6703 mL | 4.1757 mL | |
| 25 mM | 0.1336 mL | 0.6681 mL | 1.3362 mL | 3.3406 mL | |
| 30 mM | 0.1114 mL | 0.5568 mL | 1.1135 mL | 2.7838 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Imipenem Related Classifications
HY-B1369A Related Classifications
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