2. Anti-infection
  3. Bacterial Antibiotic
  4. Imipenem monohydrate

Imipenem monohydrate  (Synonyms: N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate)

Cat. No.: HY-B1369 Purity: 99.90%
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Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections.

For research use only. We do not sell to patients.

CAS No. : 74431-23-5

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Customer Review

Based on 35 publication(s) in Google Scholar

Other Forms of Imipenem monohydrate:

Imipenem monohydrate Related Antibodies

Top Publications Citing Use of Products

35 Publications Citing Use of MCE Imipenem monohydrate

Microbiological Assay
WB
IF
Histological Imaging/Staining

    Imipenem monohydrate purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2025 May 23:e0024925.  [Abstract]

    Numbers of organisms treated with 16× MIC NITD-916, 8 mg/L RFB or 16 mg/L IPM at 24 and 48 hours were significantly less than the drug-free control.

    Imipenem monohydrate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191.  [Abstract]

    Combination of ATR and IMP effectively inhibits the formation of NETs. After CLP modeling, ATR was administered with Imipenem monohydrate (25 mg/kg, subcutaneously) at 6 and 18 h. The protein levels of Cit-H3 in the lungs were detected by western blot and analyzed by grayscale.

    Imipenem monohydrate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191.  [Abstract]

    Combination of ATR and IMP effectively inhibits the formation of NETs. After CLP modeling, ATR was administered with Imipenem monohydrate (25 mg/kg, subcutaneously) at 6 and 18 h. Co-localization of Cit-H3, MPO and DAPI was observed by fluorescence microscopy and the level of NETs formation was analyzed (n = 4).

    Imipenem monohydrate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191.  [Abstract]

    Combination of ATR and IMP alleviates lung injury by inhibiting NETs. Treatments were administered at 6 and 18 h post-CLP modeling with ATR, Imipenem monohydrate (25 mg/kg, subcutaneously), and DNase I. After 24 h, lung tissues were examined for pulmonary injury and NET expression. HE staining and scoring of lung tissue, scale bar = 100 μm.

    Imipenem monohydrate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191.  [Abstract]

    Combination of ATR and IMP alleviates lung injury by inhibiting NETs. Treatments were administered at 6 and 18 h post-CLP modeling with ATR, Imipenem monohydrate (25 mg/kg, subcutaneously), and DNase I. After 24 h, lung tissues were examined for pulmonary injury and NET expression. Co-localization of Cit-H3, MPO and DAPI in NET was observed using fluorescence microscopy

    Imipenem monohydrate purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191.  [Abstract]

    Imipenem monohydrate (1, 5, 10 μM) was pre-treated with neutrophils for 2 h, followed by stimulation with LPS (5 μg/mL) for 4 h. Cit-H3 was detected by western blot.

    Imipenem monohydrate purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575.

    Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections[1][2][3].

    IC50 & Target

    β-lactam

     

    In Vivo

    Imipenem monohydrate (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent[3].
    Pharmacokinetic Parameters of Imipenem monohydrate in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single)[1].

    50
    Drug and dose(mg/kg) Cmax(mg/liter) Tmax(min) AUCtot(mg min/liter) Vz/F(ml/kg) Vss/F (ml/kg) CL/F(ml/min/kg) t1/2(min) MRT(min)
    Imipenem
    8 15 (7.1) 21 (11) 1,470 (777) 648 (330) 721 (343) 6.7 (3) 67 (11) 108 (12)
    16 34 (6) 28 (18) 2,857 (559) 507 (140) 543 (121) 5.8 (1) 60 (9.1) 94 (10)
    32 54 (11) 18 (6.1) 4,895 (635) 516 (75) 566 (83) 6.6 (0.8) 54 (6.5) 86 (11)
    64 69 (37) 15 (9.5) 6,037 (2,976) 547 (274) 617 (308) 7.4 (3.6) 43 (22) 70 (35)

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Neutropenic mouse model of biofilm lung infection[3]
    Dosage: 4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg
    Administration: 4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single
    Result: Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.
    Clinical Trial
    Molecular Weight

    317.36

    Formula

    C12H19N3O5S
    CAS No.
    Appearance

    Solid

    Color

    Off-white to yellow

    SMILES

    O=C(C(N12)=C(SCCNC=N)C[C@]2([H])[C@@H]([C@H](O)C)C1=O)O.O
    Structure Classification
    Initial Source

    Streptomyces cattleya
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years

    *The compound is unstable in solutions, freshly prepared is recommended.

    Solvent & Solubility
    In Vitro: 

    H2O : 6.25 mg/mL (19.69 mM; ultrasonic and warming and heat to 60°C)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1510 mL 15.7550 mL 31.5100 mL
    5 mM 0.6302 mL 3.1510 mL 6.3020 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 10 mg/mL (31.51 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

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    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.90%

    SDS (393 KB)

    COA (250 KB) HNMR (252 KB) RP-HPLC (276 KB) MS (71 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.1510 mL 15.7550 mL 31.5100 mL 78.7749 mL
    5 mM 0.6302 mL 3.1510 mL 6.3020 mL 15.7550 mL
    10 mM 0.3151 mL 1.5755 mL 3.1510 mL 7.8775 mL
    15 mM 0.2101 mL 1.0503 mL 2.1007 mL 5.2517 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Imipenem monohydrate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Imipenem74431-23-5N-Formimidoyl thienamycinMK0787MK 0787MK-0787BacterialAntibioticntibioticthienamycinbacteriainfectionP. aeruginosaInhibitorinhibitorinhibit

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