74431-23-5
Chemical Structure
Imipenem monohydrate
Synonym(s): N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate
- CAS No.: 74431-23-5
- Formula:C12H19N3O5S
- Molecular Weight:317.36
IUPAC Name: (5R,6S)-3-((2-formimidamidoethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate
InChIKey: GSOSVVULSKVSLQ-JJVRHELESA-N
SMILES: O=C(C(N12)=C(SCCNC=N)C[C@]2([H])[C@@H]([C@H](O)C)C1=O)O.O
Biological Activity: Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Imipenem monohydrate | 99.92% | Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections. | ||||||||||||||||||||
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Imipenem monohydrate (Standard) | 99.52% | Imipenem (monohydrate) (Standard) is the analytical standard of Imipenem (monohydrate). This product is intended for research and analytical applications. Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections. | ||||||||||||||||||||
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Similarity Score 0.98
HY-B1369AImipenem -
Similarity Score 0.86
HY-N14174Epithienamycin A -
Similarity Score 0.85
HY-W588257(+)-Thienamycin -
Similarity Score 0.77
HY-N14919Olivanic acid -
Similarity Score 0.76
HY-N14209Epithienamycin D -
Similarity Score 0.76
HY-N14966Epithienamycin B -
Similarity Score 0.74
HY-B1369ASImipenem-d4 -
Similarity Score 0.70
HY-207462CBA-4 -
Similarity Score 0.70
HY-N14210Epithienamycin F -
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References
- [1]. Johann Motsch, et al. RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections. Clin Infect Dis. 2020 Apr 15;70(9):1799-1808. [Content Brief]
- [2]. Wang Hengzhuang, et al. In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection. Antimicrob Agents Chemother. 2012 May;56(5):2683-90 [Content Brief]
- [3]. F P Tally, et al. In vitro activity of N-formimidoyl thienamycin (MK0787). Antimicrob Agents Chemother. 1980 Oct;18(4):642-4. [Content Brief]
