1212185-26-6
1212185-26-6
Chemical Structure
ML121
- CAS No.: 1212185-26-6
- Formula:C16H16N2OS2
- Molecular Weight:316.44
IUPAC Name: 9-(pyridin-3-yl)-3,4a,5,6,7,8,8a,9-octahydro-2H-5,8-methanothiochromeno[2,3-d]thiazol-2-one
InChIKey: RRGJAKVGOZYHOQ-UHFFFAOYSA-N
SMILES: O=C1SC(C(C2=CC=CN=C2)C3C(C4CCC3C4)S5)=C5N1
Biological Activity: ML121 is a selective and potent VIM-2 inhibitor with an IC50 of 54 nM and a Ki of 148 nM. ML121 shows inactive in IMP-1 and TEM-1 beta-lactamase assays. ML121 can potentiate the antibiotic activity of Imipenem (HY-B1369A) in VIM-2 transformed E.coli[1].
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ML121 | ML121 is a selective and potent VIM-2 inhibitor with an IC50 of 54 nM and a Ki of 148 nM. ML121 shows inactive in IMP-1 and TEM-1 beta-lactamase assays. ML121 can potentiate the antibiotic activity of Imipenem (HY-B1369A) in VIM-2 transformed E.coli. | |||||||||||||||||||||
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References
Keywords
