2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N2572
    Eupafolin 520-11-6 99.60%
    Eupafolin (Nepetin) (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Eupafolin inhibits IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells.
    Eupafolin
  • HY-N2605
    Camelliaside B 131573-90-5 99.43%
    Camelliaside B is a flavonoid from the methanol extract of tea (Camellia oleifera) seed pomace.
    Camelliaside B
  • HY-N3010
    Salviaflaside 178895-25-5 99.77%
    Salviaflaside is a main bioactive component of Spica Prunellae.
    Salviaflaside
  • HY-N4122
    Neodiosmin 38665-01-9 99.37%
    Neodiosmin is a flavone glycoside isolated from the leaves of Citrus aurantium.
    Neodiosmin
  • HY-N4124
    Poricoic acid B 137551-39-4 98.60%
    Poricoic acid B is a triterpenoid compound that can be isolated from Poria cocos. Poricoic acid B inhibits intracellular lipid accumulation and reduces the levels of hepatocyte injury markers. Poricoic acid B inhibits the production of NO, TNF-α, IL-1β and IL-6, thereby exerting anti-inflammatory activity. Poricoic acid B can be used in the research of metabolic dysfunction-associated fatty liver disease and inflammatory diseases[3].
    Poricoic acid B
  • HY-N4322
    Decursinol angelate 130848-06-5 99.94%
    Decursinol angelate acts as a PKC activator and GDH inhibitor, with an IC50 of 1.432 μM against human GDH. Decursinol angelate activates PKC, downregulates PKCα and PKCβII isoforms, and exerts cytotoxic activity against cancer cells. Decursinol angelate binds to GDH and inhibits its enzymatic activity. Decursinol angelate inhibits VEGF-induced autophosphorylation of VEGFR2, downstream p42/44 ERK and JNK-MAPK signaling pathways, as well as the angiogenesis process. Decursinol angelate is applicable to research related to cancer and leukemia.
    Decursinol angelate
  • HY-N5010
    Nepitrin 569-90-4 99.36%
    Nepitrin, isolated from Scrophularia striata, possess significant anti-inflammatory and anti-arthritic activity.
    Nepitrin
  • HY-N6082
    Rhein 8-O-β-D-Glucopyranoside 34298-86-7 99.81%
    Rhein 8-O-β-D-Glucopyranoside is an orally active glycoside found in Rhubarb. Rhein 8-O-β-D-Glucopyranoside attenuates high glucose-induced apoptosis, recovers altered lincRNA ANRIL and let-7a expression, reverses high glucose-altered Bcl-2 and cleaved caspase-3 protein expression, and inhibits TGF-β1/Smad signaling. Rhein 8-O-β-D-Glucopyranoside accelerates Sennoside A (HY-N0365) metabolism, stimulates sennoside A purgative activity. Rhein 8-O-β-D-Glucopyranoside inhibits bacterial biofilm formation, suppresses its virulence gene expression, and exerts antibacterial activity. Rhein 8-O-β-D-Glucopyranoside can be used for the research of diabetic nephropathy, constipation, and infection.
    Rhein 8-O-β-D-Glucopyranoside
  • HY-N6851
    Glycyrrhetic acid 3-O-β-D-glucuronide 34096-83-8 99.59%
    Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β-glucuronidases (β-GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG.Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.
    Glycyrrhetic acid 3-O-β-D-glucuronide
  • HY-N6857
    Armepavine 524-20-9 99.53%
    Armepavine, found in Nelumbo nucifera, is an orally active NF-κB inhibitor. Armepavine attenuates expression of p-p65, α-SMA, p-JNK1/2, p-ERK1/2, p-p38α stimulated by TNF-α and LPS. Armepavine suppresses NF-κB nuclear translocation, IκBα phosphorylation, and collagen deposition. Armepavine can be used for the research of hepatic fibrosis and leukemia.
    Armepavine
  • HY-N7056
    4'-Hydroxychalcone 2657-25-2 99.66%
    4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria.
    4'-Hydroxychalcone
  • HY-N9386
    Tellimagrandin II 81571-72-4 98.81%
    Tellimagrandin II (Eugeniin), with oral activity, is the first intermediate of the ellagitannin series derived from 4C1-glucose. It inhibits the resistance of Staphylococcus aureus by disrupting the integrity of the cell wall, leading to the loss of cytoplasmic contents. Additionally, Tellimagrandin II exhibits anti-inflammatory effects and inhibits acetylcholinesterase (AChE) activity, improving memory impairment. Tellimagrandin II holds potential for research in the fields of antibacterial, anti-inflammatory, and neurodegenerative diseases.
    Tellimagrandin II
  • HY-N9396
    Nasunin 28463-30-1 99.34%
    Nasunin, an antioxidant anthocyanin, possesses antiangiogenic activity.
    Nasunin
  • HY-N9487
    (R)-(-)-α-Phellandrene 4221-98-1
    (R)-(-)-α-Phellandrene ((-)-α-Phellandrene) is an the (R)-(-)-stereoisomer of α-phellandrene. α-phellandrene is an orally active cyclic monoterpene that attenuates inflammatory response, and induces DNA damage.
    (R)-(-)-α-Phellandrene
  • HY-NP113
    Highly purified Type II collagen, from chick sternal cartilage 99.00%
    Highly purified Type II collagen, from chick sternal cartilage (Chick Type II collagen, immunization grade) is an immune grade collagen derived from chick sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type II collagen, from chick sternal cartilage
  • HY-P1048
    Myelin Basic Protein (MBP) (68-82), guinea pig 98474-59-0 99.67%
    Myelin Basic Protein (MBP) (68-82), guinea pig is a fragment of myelin basic protein (MBP).
    Myelin Basic Protein (MBP) (68-82), guinea pig
  • HY-P1242
    NEP(1-40) 475221-20-6
    NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition.
    NEP(1-40)
  • HY-P1826
    CLIP (86-100) 648881-58-7 98.39%
    CLIP (86-100) is amino acids 86 to 100 fragment of class II-associated invariant chain peptide (CLIP). CLIP is a small self-peptide and cleavage product of the invariant chain that resides in the HLA-II antigen binding groove and is believed to play a critical role in the assembly and transport of MHC class II alphabetaIi complexes through its interaction with the class II peptide-binding site.
    CLIP (86-100)
  • HY-P2203
    SAHM1 2050906-89-1
    SAHM1, a peptide mimetic of a dominant negative form of mastermind-like (MAML), inhibits canonical Notch transcription complex formation. SAHM1 can be used for the research of allergic airway inflammation in mice.
    SAHM1
  • HY-P5011
    Cortistatin-17 (human) 189450-19-9 99.04%
    Cortistatin-17 (human) is a somatostatin neuropeptide with potential for studying diseases such as cancer, inflammation, autoimmunity, fibrosis, and pain.
    Cortistatin-17 (human)
Cat. No. Product Name / Synonyms Application Reactivity