Cat. No.: HY-N4124

Poricoic acid B

Customer Review

Based on 1 Customer Validation

Poricoic acid B is a triterpenoid compound that can be isolated from Poria cocos. Poricoic acid B inhibits intracellular lipid accumulation and reduces the levels of hepatocyte injury markers. Poricoic acid B inhibits the production of NO, TNF-α, IL-1β and IL-6, thereby exerting anti-inflammatory activity. Poricoic acid B can be used in the research of metabolic dysfunction-associated fatty liver disease and inflammatory diseases^[3].

For research use only. We do not sell to patients.

Purity: 98.60%
CAS No.: 137551-39-4
Formula: C₃₀H₄₄O₅
Molecular Weight:484.67

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Poricoic acid B Chemical Structure

CAS No.: 137551-39-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

All NO Synthase Isoforms :

All TNF Receptor Isoforms :

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	>100 μM Compound: 10	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 19746919]

In Vitro

Poricoic acid B (25-100 μM; 24 h) inhibits lipid accumulation in fat emulsion-induced steatotic L-02 hepatocytes and reduces the levels of hepatocyte injury markers^[1].
Poricoic acid B (0-40 μg/mL; 24 h) inhibits LPS (HY-D1056)-induced NO production in RAW 264.7 cells and reduces the secretion of proinflammatory cytokines TNF-α, IL-1β and IL-6 in the cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[3]

Cell Line:

LPS-induced RAW 264.7 mouse macrophage cells
Concentration:

10, 20, 40 μg/mL
Incubation Time:

24 h (co-incubated with LPS)
Result:

Decreased TNF-α secretion significantly across all concentrations, with the lowest level at 20 μg/mL (32% reduction compared to the LPS-treated group).
Showed no significant difference in IL-1β secretion at 10 μg/mL; reduced IL-1β secretion by 41% at 20 μg/mL and 77% at 40 μg/mL compared to the LPS-treated group.
Reduced IL-6 secretion by 30%, 53%, and 66% at 10, 20, and 40 μg/mL respectively, compared to the LPS-treated group.

Chemical Information

CAS No. 137551-39-4
Appearance Solid
Molecular Weight 484.67
Formula C₃₀H₄₄O₅
Color White to light yellow
SMILES

O=C(O)CC[C@@]1(C)[C@H](C(C)=C)CC=C2[C@]3(C)C[C@@H](O)[C@H]([C@H](C(O)=O)CC/C=C(C)\C)[C@@]3(C)CC=C21
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (515.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0633 mL

10.3163 mL

20.6326 mL

5 mM

0.4127 mL

2.0633 mL

4.1265 mL

10 mM

0.2063 mL

1.0316 mL

2.0633 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. He J, et al. Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway. Front. Pharmacol. 13:1007274.

[2]. Dong H, et al. Enrichment and separation of antitumor triterpene acids from the epidermis of Poria cocos by pH-zone-refining counter-current chromatography and conventional high-speed counter-current chromatography. J Sep Sci. 2015;38(11):1977-1982. [Content Brief]

[3]. Zhang L, et al. Anti-Inflammatory Activity of Four Triterpenoids Isolated from Poriae Cutis. Foods. 2021 Dec 20;10(12):3155. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0633 mL	10.3163 mL	20.6326 mL	51.5815 mL
	5 mM	0.4127 mL	2.0633 mL	4.1265 mL	10.3163 mL
	10 mM	0.2063 mL	1.0316 mL	2.0633 mL	5.1581 mL
	15 mM	0.1376 mL	0.6878 mL	1.3755 mL	3.4388 mL
	20 mM	0.1032 mL	0.5158 mL	1.0316 mL	2.5791 mL
	25 mM	0.0825 mL	0.4127 mL	0.8253 mL	2.0633 mL
	30 mM	0.0688 mL	0.3439 mL	0.6878 mL	1.7194 mL
	40 mM	0.0516 mL	0.2579 mL	0.5158 mL	1.2895 mL
	50 mM	0.0413 mL	0.2063 mL	0.4127 mL	1.0316 mL
	60 mM	0.0344 mL	0.1719 mL	0.3439 mL	0.8597 mL
	80 mM	0.0258 mL	0.1290 mL	0.2579 mL	0.6448 mL
	100 mM	0.0206 mL	0.1032 mL	0.2063 mL	0.5158 mL

Keywords

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Poricoic acid B

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All NO Synthase Isoforms

All TNF Receptor Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Poricoic acid B Related Classifications

Cat. No.: HY-N4124