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  5. Glycyrrhiza uralensis Fisch.
  6. Glycyrrhetic acid 3-O-β-D-glucuronide

Glycyrrhetic acid 3-O-β-D-glucuronide  (Synonyms: Glycyrrhetic acid 3-O-mono-β-D-glucuronide; 3-monoglucuronyl-glycyrrhetinic acid)

Cat. No.: HY-N6851 Purity: 99.36%
COA Handling Instructions

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Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β-glucuronidases (β-GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG.Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.

For research use only. We do not sell to patients.

Glycyrrhetic acid 3-O-β-D-glucuronide Chemical Structure

Glycyrrhetic acid 3-O-β-D-glucuronide Chemical Structure

CAS No. : 34096-83-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 383 In-stock
Solution
10 mM * 1 mL in DMSO USD 383 In-stock
Solid
1 mg USD 128 In-stock
5 mg USD 269 In-stock
10 mg USD 457 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Glycyrrhetic acid 3-O-β-D-glucuronide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity[1]. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β-glucuronidases (β-GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG[2].Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.

In Vitro

Glycyrrhetic acid 3-O-β-D-glucuronide can inhibit the release of β-hexosaminidase from RBL-2H3 cells with an IC50 value of 0.28 mM[2].
Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) significantly reduces the nitrite concentration in a dose-dependent manner with an IC50 value of 120 μM in LPS-induced RAW264.7 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glycyrrhetic acid 3-O-β-D-glucuronide Related Antibodies
Molecular Weight

646.81

Formula

C36H54O10
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]1([C@@]2([H])[C@@]3([C@@](C(C)([C@@H](O[C@]4([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)CC3)C)([H])CC1)C)[C@]5(C([C@@]6([H])[C@](C)(CC[C@@](C(O)=O)(C)C6)CC5)=CC2=O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (386.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5460 mL 7.7302 mL 15.4605 mL
5 mM 0.3092 mL 1.5460 mL 3.0921 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (3.22 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (3.22 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5460 mL 7.7302 mL 15.4605 mL 38.6512 mL
5 mM 0.3092 mL 1.5460 mL 3.0921 mL 7.7302 mL
10 mM 0.1546 mL 0.7730 mL 1.5460 mL 3.8651 mL
15 mM 0.1031 mL 0.5153 mL 1.0307 mL 2.5767 mL
20 mM 0.0773 mL 0.3865 mL 0.7730 mL 1.9326 mL
25 mM 0.0618 mL 0.3092 mL 0.6184 mL 1.5460 mL
30 mM 0.0515 mL 0.2577 mL 0.5153 mL 1.2884 mL
40 mM 0.0387 mL 0.1933 mL 0.3865 mL 0.9663 mL
50 mM 0.0309 mL 0.1546 mL 0.3092 mL 0.7730 mL
60 mM 0.0258 mL 0.1288 mL 0.2577 mL 0.6442 mL
80 mM 0.0193 mL 0.0966 mL 0.1933 mL 0.4831 mL
100 mM 0.0155 mL 0.0773 mL 0.1546 mL 0.3865 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycyrrhetic acid 3-O-β-D-glucuronide34096-83-8Glycyrrhetic acid 3-O-mono-β-D-glucuronide 3-monoglucuronyl-glycyrrhetinic acidOthersInhibitorinhibitorinhibit

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