Anti-allergic activity of 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide

  • Arch Pharm Res. 2004 Jan;27(1):57-60. doi: 10.1007/BF02980047.
Hae-Young Park  1 ,  Sung-Hwan Park ,  Hae-Kyung Yoon ,  Myung Joo Han ,  Dong-Hyun Kim
Affiliations
  • 1. Department of Food and Nutrition, Kyung Hee University, Hoegi #1, Dongdaemun-ku, Seoul 130-701, Korea.
PMID: 14969340 DOI: 10.1007/BF02980047
Abstract

Glycyrrhizin (18beta-glycyrrhetinic acid-3-O-beta-D-glucuronopyranosyl-(1 --> 2)-beta-D-glucuronide, GL) was transformed to 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide (GAMG) by Streptococcus LJ-22. The antiallergic activities of GL and GAMG was measured using a RBL cell assay system and contact hypersensitivity model mice. GAMG exhibited anti-allergic activity with IC50 values of 0.28 mM. GAMG, which is sweeter than GL, and 18beta-glycyrrhetinic acid, which is a GAMG metabolite by human intestinal bacteria, also inhibited the passive cutaneous anaphylaxis and skin contact inflammation. In conclusion, GAMG may be useful as a new sweet food additive and an anti-allergic agent.

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