Quercitrin (Synonyms: Quercetin 3-rhamnoside)

Name: Quercitrin
Brand: MedChemExpress
SKU: HY-N0418
Rating: 5.0 (6 reviews)

Cat. No.: HY-N0418 Purity: 99.82%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Quercitrin (Quercetin 3-rhamnoside) is a bioflavonoid compound with potential anti-inflammation, antioxidative and neuroprotective effect. Quercitrin induces apoptosis of colon cancer cells. Quercitrin can be used for the research of cardiovascular and neurological disease research.

For research use only. We do not sell to patients.

CAS No. : 522-12-3

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Quercitrin:

Quercitrin (Standard) In-stock

6 Publications Citing Use of MCE Quercitrin

IHC

: Quercitrin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 May:127:155467.; Quercitrin (Que 80 mg/kg). Western blot images of fibronectin, collagen I, α-SMA, and GAPDH.

: Quercitrin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 May:127:155467.; Quercitrin (Que 80 mg/kg). Masson staining of the MI group and the MI+Que group.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ribosomal S6 Kinase (RSK) Isoform Specific Products:

View All Isoforms

p70S6K RSK2 RSK3 RSK4

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 20 mg/mL Compound: 20	Cytotoxicity against human A549 cells after 3 days by SRB assay Cytotoxicity against human A549 cells after 3 days by SRB assay	[PMID: 15568778]
BALB/3T3	IC₅₀	> 223 μM Compound: 7	Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay	[PMID: 10096863]
BV-2	IC₅₀	> 100 μM Compound: 3	Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction	[PMID: 27623545]
L6	IC₅₀	> 30 μg/mL Compound: 18	Antitrypanosomal activity against trypomastigote forms of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells after 96 hrs by photometric method Antitrypanosomal activity against trypomastigote forms of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells after 96 hrs by photometric method	10.1039/C5MD00481K
L6	IC₅₀	> 90 μg/mL Compound: 18	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence analysis Cytotoxicity against rat L6 cells after 72 hrs by alamar blue staining based fluorescence analysis	10.1039/C5MD00481K
MCF7	IC₅₀	> 20 mg/mL Compound: 20	Cytotoxicity against human MCF7 cells after 3 days by SRB assay Cytotoxicity against human MCF7 cells after 3 days by SRB assay	[PMID: 15568778]
MDCK	CC₅₀	> 446 μM Compound: Quercitrin	Cytotoxicity against MDCK cells Cytotoxicity against MDCK cells	[PMID: 25096296]

In Vitro

Quercitrin (5-50 μM; 24-72 h) time- and dose-dependently inhibits cell proliferation and increases cytotoxic effects to colorectal carcinoma cells^[1].
Quercitrin (5-50 μM; 24-72 h) time- and dose-dependently increases nucleosomal enrichment factor (EF) of DLD-1 cells^[1].
Quercitrin (50 μM; 48-72 h) induces cell apoptosis and the loss of mitochondrial membrane potential, and causes translocation of phosphatidylserine (PS) from the inner to outer Leaflet of DLD-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	DLD-1 colon cancer cell lines
Concentration:	5, 10, 25 and 50 μM
Incubation Time:	24, 48 and 72 hours
Result:	Time- and Dose-dependently decreased cell proliferation of colorectal carcinoma cells.

Apoptosis Analysis^[1]

Cell Line:	DLD-1 colon cancer cell lines
Concentration:	50 μM
Incubation Time:	48 and 72 hours
Result:	Induced cell apoptosis and time- and dose-dependently increased caspase-3 enzyme activity.

In Vivo

Quercitrin (50 and 100 mg/kg; oral gavage, once) shows effective protection against brain injury in mice by inhibiting oxidative stress and inflammation induced by carbon tetrachloride^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR mice with carbon tetrachloride (CCl4) induced brain injury^[2]
Dosage:	50 and 100 mg/kg
Administration:	Oral gavage; 50 and 100 mg/kg, once
Result:	Dose-dependently decreased the levels of ROS and malondialdehyde (MDA) concentration in the hippocampus homogenates, and also dose-dependently decreased the CYP2E1 level in the brains. Increased the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx). Inhibited the N-methyl-D-aspartate receptor 2B subunit (NR2B) level and the activities of monoamine oxidase (MAO) and acetylcholine esterase (AChE) in mouse brains.

Molecular Weight

448.38

Formula

C₂₁H₂₀O₁₁

CAS No.

522-12-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=CC(O)=C(C(C(O[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)=C(C3=CC(O)=C(O)C=C3)O4)=O)C4=C1

Structure Classification

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (278.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2303 mL	11.1513 mL	22.3025 mL
5 mM	0.4461 mL	2.2303 mL	4.4605 mL
10 mM	0.2230 mL	1.1151 mL	2.2303 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.58 mg/mL (5.75 mM); Clear solution

This protocol yields a clear solution of ≥ 2.58 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.64 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (283 KB) SDS (393 KB)

COA (258 KB) HNMR (288 KB) RP-HPLC (246 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Cincin ZB, et al. Apoptotic Effects of Quercitrin on DLD-1 Colon Cancer Cell Line. Pathol Oncol Res. 2015 Apr;21(2):333-8. [Content Brief]

[2]. Cincin ZB, et al. Apoptotic Effects of Quercitrin on DLD-1 Colon Cancer Cell Line. Pathol Oncol Res. 2015 Apr;21(2):333-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2303 mL	11.1513 mL	22.3025 mL	55.7563 mL
	5 mM	0.4461 mL	2.2303 mL	4.4605 mL	11.1513 mL
	10 mM	0.2230 mL	1.1151 mL	2.2303 mL	5.5756 mL
	15 mM	0.1487 mL	0.7434 mL	1.4868 mL	3.7171 mL
	20 mM	0.1115 mL	0.5576 mL	1.1151 mL	2.7878 mL
	25 mM	0.0892 mL	0.4461 mL	0.8921 mL	2.2303 mL
	30 mM	0.0743 mL	0.3717 mL	0.7434 mL	1.8585 mL
	40 mM	0.0558 mL	0.2788 mL	0.5576 mL	1.3939 mL
	50 mM	0.0446 mL	0.2230 mL	0.4461 mL	1.1151 mL
	60 mM	0.0372 mL	0.1859 mL	0.3717 mL	0.9293 mL
	80 mM	0.0279 mL	0.1394 mL	0.2788 mL	0.6970 mL
	100 mM	0.0223 mL	0.1115 mL	0.2230 mL	0.5576 mL

Quercitrin Related Classifications

Neurological Disease Inflammation/Immunology Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quercitrin522-12-3Quercetin 3-rhamnosideRibosomal S6 Kinase (RSK)ApoptosisAutophagyReactive Oxygen Species (ROS)S6Kcolon cancerquercitrinantiproliferativeapoptosisanti-inflammationneuroprotectiveInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Quercitrin (Synonyms: Quercetin 3-rhamnoside)

Customer Review

Other Forms of Quercitrin:

Quercitrin Related Antibodies

6 Publications Citing Use of MCE Quercitrin

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ribosomal S6 Kinase (RSK) Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Quercitrin Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Quercitrin Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report