2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P990187
    Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) 99%
    Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) does not react with I-Af, I-Ak, or I-As haplotypes. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) blocks MHC Class II and inhibit T cell generation. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) can be used for the researches of infection and immunology, such as influenza A virus (IAV) infection.
    Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114)
  • HY-P990285
    Anti-Mouse CD200 Antibody (OX-90)
    Anti-Mouse CD200 Antibody (OX-90) is an anti-mouse CD200 IgG2a monoclonal antibody. Anti-Mouse CD200 Antibody (OX-90) can reduce immune cell infiltration and T cell function by blocking CD200. Anti-Mouse CD200 Antibody (OX-90) can be used for research on immunology.
    Anti-Mouse CD200 Antibody (OX-90)
  • HY-P990312
    ABT-325 99.75%
    ABT-325 is a humanized antibody expressed in CHO that targets IL-18. ABT-325 has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 146.28 kDa. The isotype control for ABT-325 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    ABT-325
  • HY-P990326
    Anti-ACVR2A Antibody (Ab-14E1)
    Anti-ACVR2A Antibody (Ab-14E1) is a CHO-expressed human antibody that targets ACVR2A. Anti-ACVR2A Antibody (Ab-14E1) features an IgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-ACVR2A Antibody (Ab-14E1) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-ACVR2A Antibody (Ab-14E1)
  • HY-P990351
    Anti-CD34 Antibody 99.90%
    The Anti-CD34 Antibody is a human-derived antibody expressed in CHO, targeting CD34. The Anti-CD34 Antibody contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-CD34 Antibody can be referenced from Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-CD34 Antibody
  • HY-P990498
    Selcodebart 3038196-66-3 99.40%
    Selcodebart (Anti-RGMC/HFE2 Antibody (DISC-0974)) is a CHO-expressed human antibody that targets RGMC/HFE2. Selcodebart features a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.66 kDa. For the isotype control of Selcodebart, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Selcodebart
  • HY-P990572
    DCBY02 98.71%
    DCBY02 is a monoclonal antibody targeting CD93 expressed in CHO cells. DCBY02 has a heavy chain of the mlgG type and a light chain of the mkappa type, with a predicted molecular weight (MW) of 150 kDa. The isotype control for DCBY02 can be referenced as Mouse IgG1 kappa, Isotype Control.
    DCBY02
  • HY-P990659
    Anti-LY6E Antibody (MLYE4489A) 98.47%
    Anti-LY6E Antibody (MLYE4489A) (RG-7841 antibody) is a humanized antibody expressed in CHO targeting Ly6E. Anti-LY6E Antibody (MLYE4489A) contains huIgG2 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-LY6E Antibody (MLYE4489A) can refer to Human IgG2 kappa, Isotype Control (HY-P99002).
    Anti-LY6E Antibody (MLYE4489A)
  • HY-P990713
    Nolavetbart 2750248-93-0
    Nolavetbart is an anti-Canlupfam IL31RA IgG2 κ monoclonal antibody.
    Nolavetbart
  • HY-P990757
    Ragistomig 2763222-58-6
    Ragistomig can simultaneously target programmed death-ligand 1 (PD-L1) and the 4-1BB receptor. Ragistomig elicits potent anti-tumor T-cell responses without inducing significant toxicity. Ragistomig is applicable for tumor research.
    Ragistomig
  • HY-P991033
    Tovecimig 2923284-73-3
    HY-P991033 is an VEGFA/DLL4-targeting G1-scFvlh_L-κ type bispecific antibody.
    Tovecimig
  • HY-P991266
    SM-17
    SM-17 is a humanized monoclonal antibody inhibitor targeting interleukin 25 (IL-25) and interleukin-17 receptor B (IL17RB). SM-17 is promising for research of immune system diseases.
    SM-17
  • HY-P991400
    GSK1995057 99.09%
    GSK1995057 is a human monoclonal antibody (mAb) targeting TNFRSF1A. GSK1995057 selectively binds to TNFR1, blocks the binding of TNF-α and LT-α, and does not interfere with TNFR2 signaling. GSK1995057 inhibits the activation of NF-κB, JNK and MAPK pathways, alleviates apoptosis (apoptosis) and inflammatory responses (inhibiting IL-1β, IL-6, IL-10, TNF-α), and prevents viability loss of human nucleus pulposus cells. GSK1995057 inhibits the expression of cytokines and neutrophil adhesion molecules in human pulmonary microvascular endothelial cell monolayers, and reduces inflammatory responses and lung injury symptoms in non-human primates. GSK1995057 forms complexes with HAVH autoantibodies, thereby activating TNFR1 and triggering the release of cytokines and IL-8 in human cells. GSK1995057 can be used in research related to intervertebral disc degeneration and acute lung injury.
    GSK1995057
  • HY-P991598
    MOR-106 2304625-87-2
    MOR-106 (MOR12743) is a humanized anti-IL-17C IgG1 monoclonal antibody. MOR-106 inhibits the NF-κB signaling pathway by specifically binding to IL-17C (IC50 = 59 pM for human IL-17C, IC50 = 55 pM for mouse IL-17C). MOR-106 can effectively inhibit skin inflammation and reduce related inflammatory factors in animal models of psoriasis and atopic dermatitis.
    MOR-106
  • HY-P991631
    Human IgG1 (L234F/L235E/P331S) kappa, Isotype Control 99.60%
    Human IgG1 (L234F/L235E/P331S) kappa, Isotype Control, a human-derived antibody, is an isotype control for human IgG1 (L234F/L235E/P331S)κ antibody.
    Human IgG1 (L234F/L235E/P331S) kappa, Isotype Control
  • HY-P991670
    Abdakibart 3034641-53-4 98.30%
    Abdakibart is a humanized IgG4 monoclonal antibody inhibitor targeting IL-1β. Abdakibart can be used for inflammatory disease like type 2 diabetes research.
    Abdakibart
  • HY-P991761
    Anti-Mouse CXCL10 Antibody (1F11)
    Anti-Mouse CXCL10 Antibody (1F11) reacts with the pro-inflammatory CXCL10. Anti-Mouse CXCL10 Antibody (1F11) can be used for neutralization of CXCL10 (in vitro and in vivo) and for inhibition of T cell recruitment in vivo in a range of inflammatory disease models. Recommend Isotype Controls: Polyclonal Armenian hamster IgG, Isotype Control (HY-P990305).
    Anti-Mouse CXCL10 Antibody (1F11)
  • HY-P991797
    Anti-Mouse IL-17A Antibody (BZN035)
    Anti-Mouse IL-17A Antibody (BZN035) targets mouse IL-17A that can neutralize IL-17 in mice. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978).
    Anti-Mouse IL-17A Antibody (BZN035)
  • HY-W008393
    (-)-Corey lactone diol 32233-40-2 ≥98.0%
    (-)-Corey lactone diol is the reduced form of Corey aldehyde. (-)-Corey lactone diol can be used as a drug intermediate for the synthesis of Beraprost (HY-13569A).
    (-)-Corey lactone diol
  • HY-W013549
    6-Aminopenicillanic acid 551-16-6
    6-Aminopenicillanic acid (6-APA) is a parent amine, an important precursor for the synthesis of β-lactam antibiotics and an antibacterial agent. 6-Aminopenicillanic acid interferes with cell wall synthesis during bacterial division in a manner similar to penicillin. 6-Aminopenicillanic acid has antibacterial activity against Gram-negative bacteria. 6-Aminopenicillanic acid is mainly used in the study of Penicillin-associated immune responses.
    6-Aminopenicillanic acid
Cat. No. Product Name / Synonyms Application Reactivity