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Cat. No.: HY-P991670

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Biologically Validated

Abdakibart

Name: Abdakibart
Brand: MedChemExpress
SKU: HY-P991670
Price: 400.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: AVTX-009)

Customer Review

Based on 1 Customer Validation

Abdakibart (AVTX-009) is a humanized IgG4 monoclonal antibody inhibitor targeting IL-1β. Abdakibart is applicable to research on inflammatory diseases such as type 2 diabetes.

For research use only. We do not sell to patients.

Purity: 98.30%
CAS No.: 3034641-53-4
Molecular Weight:145.905 kDa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Abdakibart Chemical Structure

CAS No.: 3034641-53-4

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Price

Stock

Quantity

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Abdakibart (AVTX-009) is a humanized IgG4 monoclonal antibody inhibitor targeting IL-1β. Abdakibart is applicable to research on inflammatory diseases such as type 2 diabetes^[1].

Isotype

Human IgG4 kappa

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target^[1]

IL-1β

All Interleukin Related Isoforms :

In Vitro

IL-1β is a key pro-inflammatory cytokine. It is released after being activated and cleaved to maturity by inflammasomes, and mediates local and systemic inflammatory responses, immune cell recruitment, and fever.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

3553 [NCBI]

Accession

P01584

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG4-kappa

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized IL-1 beta Protein, Human (N-His, HY-P700254) can bind Abdakibart. The EC₅₀ for this effect is 104.6 ng/mL.

Chemical Information

CAS No. 3034641-53-4
Appearance Liquid
Molecular Weight 145.905 kDa
Color Colorless to light yellow
SMILES

N/A
Synonyms

AVTX-009
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (255 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Internacionales D C. International Nonproprietary Names for Pharmaceutical Substances (INN)[J]. WHO Drug Information, 2025, 39(2).

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

Abdakibart

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

All Interleukin Related Isoforms