Abdakibart
Based on 1 Customer Validation
Abdakibart (AVTX-009) is a humanized IgG4 monoclonal antibody inhibitor targeting IL-1β. Abdakibart is applicable to research on inflammatory diseases such as type 2 diabetes.
For research use only. We do not sell to patients.
- Purity : 98.30%
- CAS No.: 3034641-53-4
- Molecular Weight:145.905 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
IL-1β |
In Vitro
IL-1β is a key pro-inflammatory cytokine. It is released after being activated and cleaved to maturity by inflammasomes, and mediates local and systemic inflammatory responses, immune cell recruitment, and fever.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG4-kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized IL-1 beta Protein, Human (N-His, HY-P700254) can bind Abdakibart. The EC50 for this effect is 104.6 ng/mL.
Chemical Information
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CAS No. 3034641-53-4
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Appearance Liquid
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Molecular Weight 145.905 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Synonyms
AVTX-009
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (255 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)