Anti-Mouse CD200 Antibody (OX-90)
Based on 1 Customer Validation
Anti-Mouse CD200 Antibody (OX-90) is an anti-mouse CD200 IgG2a monoclonal antibody. Anti-Mouse CD200 Antibody (OX-90) can reduce immune cell infiltration and T cell function by blocking CD200. Anti-Mouse CD200 Antibody (OX-90) can be used for research on immunology.
For research use only. We do not sell to patients.
- Purity: 95.00%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Rat IgG2a kappa
Mouse
CD200
Anti-Mouse CD200 Antibody (OX-90) (200 μg, i.v., on day 3, 6, 9,12) can weaken the therapeutic effect of anti-PD-L1 mAb in female C57BL/6 mice bearing MC38 or EG7 tumors[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5×105 Yumm1.7 cells injected C57BL/6 mice[1]
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Dosage:250 μg
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Administration:Intraperitoneal injection (i.p.), once every 3 days, from day 7 to day 18
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Result:Reduced immune cells in tumors and upregulated CCL8 expression.
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Animal Model:5×105 MC38 or EG7 cells injected female C57BL/6 mice (6-8 weeks)[2]
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Dosage:200 μg
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Administration:Intravenous injection (i.v.), on day 3, 6, 9,12
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Result:Weakened the therapeutic effect of anti-PD-L1 mAb.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo CD200 blockade; in vitro CD200 blockade; Immunohistochemistry (frozen); Immunofluorescenc
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD200 Antibody (OX-90)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Talebian F, et al. CD200 Blockade Modulates Tumor Immune Microenvironment but Fails to Show Efficacy in Inhibiting Tumor Growth in a Murine Model of Melanoma. Front Cell Dev Biol. 2021 Oct 8;9:739816. [Content Brief]
[2]. Wang X, et al. CD200+ cytotoxic T lymphocytes in the tumor microenvironment are crucial for efficacious anti-PD-1/PD-L1 therapy. Sci Transl Med. 2023 Jan 18;15(679):eabn5029. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD200 Antibody (OX-90) Related Classifications
HY-P990285 Related Classifications
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